A5102876790- Nanoplatforms for cancer theranostics
- Simulation and Modeling Applications
- Cell Adhesion Molecules Research
- Mitochondrial Function and Pathology
- Cellular Mechanics and Interactions
- ATP Synthase and ATPases Research
- Renal and related cancers
- Luminescence and Fluorescent Materials
- Porphyrin and Phthalocyanine Chemistry
- RNA and protein synthesis mechanisms
- Genetic Syndromes and Imprinting
- 3D Printing in Biomedical Research
- Advanced Sensor and Control Systems
- Cancer Cells and Metastasis
- Advanced Computational Techniques and Applications
- Skin and Cellular Biology Research
- Industrial Technology and Control Systems
- Genetic and Kidney Cyst Diseases
- RNA Interference and Gene Delivery
- Phagocytosis and Immune Regulation
- Luminescence Properties of Advanced Materials
- Photodynamic Therapy Research Studies
- Autophagy in Disease and Therapy
- Immune cells in cancer
- MicroRNA in disease regulation
Second Military Medical University
2018-2024
China Academy Of Machinery Science & Technology (China)
2022
Tumor-associated macrophages (TAMs), one of the dominating constituents tumor microenvironment, are important contributors to cancer progression and treatment resistance. Therefore, regulation TAMs polarization from M2 phenotype towards M1 has emerged as a new strategy for immunotherapy. Herein, we successfully initiated antitumor immunotherapy by inhibiting via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles (PEG-AuNPs). PEG-AuNPs suppressed in both vitro vivo...
Light has several advantages as the stimulus for a triggered drug release. Currently, applications of phototriggered drug-release devices (PDDs) are largely limited by two factors: tissue penetration and detrimental effects caused excitation light (ultraviolet or visible light). To address this disadvantage, study developed nanocomposites based on upconversion nanoparticles (UC), which could convert near-infrared to ultraviolet-visible trigger By loading UC doxorubicin (DOX) into...
Purpose Tumor RNA vaccines can activate dendritic cells to generate systemic anti-tumor immune response. However, due easily degraded of RNA, direct vaccine is less effective. In this study, we optimized the method for preparing PEGylated liposom-polycationic DNA complex (LPD) nanoliposomes, increased encapsulate amount total derived from CT-26 colorectal cancer cells. LPD nanoliposomes improved response ability tumor and effectively promote therapeutic effect oxaliplatin.Methods Total...
Biomimetic nanocarrier structure and schematic illustration of the proposed strategy promoting treatment glioma for cancer stem cell therapy in combination with chemotherapeutics.
Autosomal dominant polycystic kidney disease (ADPKD), a single-gene-inherited disease, is common cause of end-stage (ESKD). The PKD1 gene mutation the most ADPKD, accounting for approximately 78% cases. ADPKD characterized by scattered distribution multiple cysts in renal parenchyma, ultimately leading to ESKD. We collected peripheral blood mononuclear cells from patient with who carries heterozygous and reprogrammed them into induced pluripotent stem (iPSCs). iPSC lines can provide valuable...
This paper presents a design method of simulation result record base, which includes recording module, management analysis module and playback module. The base records manages the results system comprehensive evaluation, provides platform for data, also data support equipment performance analysis, report, playback, model verification calibration in later stage.
This paper presents a simulation method and software for the interaction between environment equipment mobility, including model of natural geographical mobility performance, man-made battlefield performance. The elements can simulate trafficability, collision detection passage, which effectively support simulation.
This paper presents a design method of power field reconstruction system based on empirical formula, and realizes the software this method. includes five parts: warhead structure parametric modeling subsystem, calculation simulation three-dimensional presentation model setting management database subsystem so on. There is data exchange between various parts. Based method, can be reconstructed.