A5038145312- Phytochemicals and Antioxidant Activities
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Diabetes Treatment and Management
- Pharmacovigilance and Adverse Drug Reactions
- Electroconvulsive Therapy Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Horticultural and Viticultural Research
- Natural product bioactivities and synthesis
- Bee Products Chemical Analysis
- Plant biochemistry and biosynthesis
- Fermentation and Sensory Analysis
- Monoclonal and Polyclonal Antibodies Research
- Pharmaceutical studies and practices
- Treatment of Major Depression
- RNA Interference and Gene Delivery
- Chronic Lymphocytic Leukemia Research
- HER2/EGFR in Cancer Research
- Nanoparticle-Based Drug Delivery
- Colorectal Cancer Treatments and Studies
- Phytochemical and Pharmacological Studies
- Chromium effects and bioremediation
- Growth Hormone and Insulin-like Growth Factors
- Virus-based gene therapy research
- Thyroid Disorders and Treatments
Lucian Blaga University of Sibiu
2016-2025
Colorectal cancer (CRC) is the third most common in world, with an average 5-year overall survival (OS) rate of approximately 60% [...].
Trastuzumab (T) and tyrosine kinase inhibitors (TKIs) are among the first-line treatments recommended for HER2-positive breast cancer. More recently, antibody-drug conjugates (ADCs) such as trastuzumab deruxtecan (T-DXd) emtansine (T-DM1) have been authorized, they represent second-line therapy in this type of The present study aimed to evaluate adverse drug reactions (ADRs) associated with T-based ADCs that were spontaneously reported EudraVigilance—the European pharmacovigilance database....
The aim of this study was to determine the variability several chemical compounds and antioxidant antimicrobial activities eight types berries harvested from two different geographical regions in same year. analyses were performed on bilberry, black currant, gooseberry, red raspberry, sea buckthorn, strawberry sour cherry, which handpicked during summer 2019, periods when they are typically for consumer purposes. Total anthocyanins content (TAC), total flavonoids (TFC), polyphenolic (TPC),...
Grape pomace and berries represent natural sources of phytochemicals that can increase the quality life consumers by contributing to prevention chronic diseases; thus, development a dietary supplement was necessary. The raw material (r.m.) used for consisted dried powdered bilberries (Vaccinium myrtillus L.), red currants (Ribes rubrum fermented pomaces (Vitis vinifera L.) from Feteasca Neagra Cabernet Sauvignon cultivars. particle size distribution, powder flow, total phenolic content...
Direct oral anticoagulant drugs (DOACs) interfere with the coagulation process, thus improving patient care for those who require treatment. This study presents a descriptive analysis of adverse reactions (ADRs) attributed to DOAC dosage errors (overdose, underdose, and improper dose). The was performed based on Individual Case Safety Reports from EudraVigilance (EV) database. Results show that data reported rivaroxaban, apixaban, edoxaban, dabigatran are mostly regarding underdosing...
Capecitabine (CAP) is one of the most commonly prescribed fluoropyrimidines in oncology, especially treatment colon cancer. Cardiac toxicity a severe and potentially lethal adverse drug reaction (ADR) against fluoropyrimidines. ADRs, such as myocardial infarction (MI), heart failure (HF), arrhythmias, number cardiomyopathies, are reported for these molecules. To have better understanding risk-benefit ratio cancer therapy, pharmacovigilance study real-world evidence cardiac antineoplastic...
Bioactive compounds extracted from plants can provide wide health benefits. However, some molecules have limited applications as pharmaceuticals due to their solubility, poor bioavailability, and low stability when exposed environmental factors. Their integration in formulations that deliver them physiological targets while preserving biological activity enhance usage improving human health. This research provides a delivery system design the mask bitter taste of salicin. Thus, novel...
Depression persists as one of the illnesses described relentlessly through centuries because it affects a large group people. Background/Objectives: The treatment depression consists various therapeutic agents, among which selective serotonin reuptake inhibitors (SSRIs) are elective. As polypharmacy tends to become norm in modern days, study real-life occurrence drug-drug interactions is imperative. aim this was evaluation (DDIs) between antidepressant medicines, namely SSRIs (each...
Background/Objectives: Worldwide, colon cancer is a major cause of cancer-related mortality, with an increasing incidence influenced by genetic, environmental, and lifestyle factors. Despite advances in diagnosis personalized treatments, challenges remain improving patient prognosis, particularly metastatic colorectal (mCRC). Bevacizumab (BEV), monoclonal antibody, widely used treatment. This study aimed to analyze adverse events associated BEV compared other therapies based on data from the...
Bilberries (Vaccinium myrtillus L.) have been reported to hold a plentitude of health-promoting properties beyond basic nutrition, mainly attributed their anthocyanin content and antioxidant activity. In this article, we built the phytochemical profile three wild bilberry fruit extract formulations (aqueous, methanolic, hydro-methanolic) using UHPLC-ESI-MS/MS putative analysis, identifying 88 individual phytochemicals, flavonoids (total 8.41 ± 0.11 mg QE/g dw), free amino acids, polyphenols...
Nowadays, an increased concern regarding using natural products for their health benefits can be observed. The aim of this study was to assess and compare several phenolic compounds found in 15- 60-year-old Douglas fir, silver larch, pine, spruce needle bark extracts evaluate antioxidant antimicrobial activities. Spectrophotometric assays were used determine the total polyphenol content activity that assessed by DPPH• radical scavenging assay (RSA), ferric reducing power (FRAP), ABTS•+...
Glucosinolates-rich extracts of some Brassicaceae sources, such as broccoli, cabbage, black radish, rapeseed, and cauliflower, were obtained using an eco-friendly extraction method, in a microwave field, with 70% ethanol, evaluated order to establish their vitro antioxidant activities anticorrosion effects on steel material. The DPPH method Folin-Ciocâlteu assay proved good activity (remaining DPPH, 9.54-22.03%) the content total phenolics between 1008-1713 mg GAE/L for all tested extracts....
This study aimed to evaluate the comparative biological effects of Polygonum aviculare L. herba (PAH) extract and quercetin-entrapped liposomes on doxorubicin (Doxo)-induced toxicity in HUVECs. HUVECs were treated with two formulations loaded PAH (L5 L6) quercetin (L3 prepared phosphatidylcholine L4 phosphatidylserine). The results obtained atomic force microscopy, zeta potential entrapment liposome efficiency confirmed interactions or free a controlled release flavonoids entrapped all...
Some glucagon-like peptide-1 receptor agonists (GLP-1 RAs), first used in the treat-ment of type 2 diabetes mellitus (T2DM), have been approved for treatment obe-sity patients with or without T2DM (liraglutide – LIR, semaglutide - SEM, and tir-zepatide TIR). Social media had an important influence on off-label use GLP-1 RAs obesity, especially SEM. We analysed Google queries related to SEM assess people's interest this drug. also investigated occurrence adverse drug reactions (ADRs)...
Some glucagon-like peptide-1 receptor agonists (GLP-1 RAs), first used in the treatment of type 2 diabetes mellitus (T2DM), have been approved for obesity patients with or without T2DM (liraglutide—LIR, semaglutide—SEM, and tirzepatide—TIR). Social media had an important influence on off-label use GLP-1 RAs obesity, especially SEM. We analyzed Google queries related to SEM assess people’s interest this drug. also investigated occurrence adverse drug reactions (ADRs) by searching...
As the most common psychiatric symptom, depression represents a subject of high interest for medical community.
Salvia officinalis L. and Plantago lanceolata are plants found in Romania's natural flora. They have been used for a long time folk medicine due to their beneficial properties based upon phenolic compound content. This study compared these hydroalcoholic extracts of separately 1:1 mixture determined the concentration several compounds that possess antioxidant properties. Nine compounds, including (+)-catechin, syringic acid, cinnamic resveratrol, chlorogenic caffeic ferulic rutin quercetin,...
The extracts obtained from two types of berries: red currant and raspberries, were evaluated for their phenolic content. They identified quantified by using an optimized HPLC method. During the analyze several compounds found, like: gallic acid, (+)- catechin, syringic cinnamic chlorogenic ferulic rutin quercetin. total amount analyzed found in was greater than one due to low variety extracted. greatest acid determined extraction berries raspberries extract contained source This study shows...