A5041123909- Gamma-ray bursts and supernovae
- Photonic and Optical Devices
- Advanced MEMS and NEMS Technologies
- Nuclear physics research studies
- Semiconductor Lasers and Optical Devices
- Geotechnical Engineering and Soil Stabilization
- Orbital Angular Momentum in Optics
- Astrophysics and Cosmic Phenomena
- Stellar, planetary, and galactic studies
- Advanced Fiber Optic Sensors
- Advanced Measurement and Metrology Techniques
- Geotechnical Engineering and Underground Structures
- Pulsars and Gravitational Waves Research
- Astro and Planetary Science
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Microfluidic and Bio-sensing Technologies
- Neutrino Physics Research
- Mechanical and Optical Resonators
- Advanced Surface Polishing Techniques
- Lung Cancer Research Studies
- Optical Coatings and Gratings
- Advanced optical system design
- Pancreatic and Hepatic Oncology Research
The University of Tokyo
2018-2024
Kyoto Prefectural University of Medicine
2018-2024
Kyoto Sangyo University
2021-2022
Fukuyama City Hospital
2022
Kyoto University
2017-2020
Kindai University
2016-2018
Railway Technical Research Institute
2012-2016
Geotechnical and Structures Laboratory
2007
Kyushu University
2007
Interdisciplinary Scientific Research
2005
Abstract Recent observations of supernovae (SNe) have indicated that a fraction massive stars possess dense circumstellar medium (CSM) at the moment their core collapses. They suggest presence additional activities SN progenitor driving enhancement mass-loss rate, and some physical processes attributing to single star’s been considered. In this study, we carry out binary evolutionary simulations by MESA investigate effects on subsequent CSM formation through hydrodynamical PLUTO . We show...
Abstract Driver oncogenes are investigated upfront at diagnosis using multi‐CDx systems with next‐generation sequencing techniques or multiplex reverse‐transcriptase polymerase chain reaction assays. Additionally, from 2019, comprehensive genomic profiling (CGP) assays have been available in Japan for patients advanced solid tumors who had completed were expected to complete standard chemotherapy. These comprehensively detect the driver oncogenes, especially non‐small cell lung cancer...
We previously reported that combined therapy with epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) osimertinib and AXL ONO-7475 is effective in preventing the survival of drug-tolerant cells high-AXL-expressing EGFR-mutated non-small cell lung cancer (NSCLC) cells. Nevertheless, certain residual are anticipated to eventually develop acquired resistance this combination therapy. In study, we attempted establish a multidrug from first-line setting overcome NSCLC. siRNA...
Fluorinated polyimide micro-objects (6–7.5 μm cross-sectional radius) fabricated using reactive ion etching have been both optically trapped and simultaneously rotated in high low relative–refractive index surrounding media. Symmetrical with a were by exerting optical radiation pressure through their center openings strongly focused trapping laser beam. Micro-objects the when horizontal cross sections of these objects showed dissymmetry (that is, not bilateral but rotational symmetry). In...
Abstract Background A history of pre-administration immune checkpoint inhibitors has been reported to be associated with good outcomes ramucirumab (RAM) plus docetaxel (DOC) combination therapy for advanced non-small-cell lung cancer (NSCLC). However, existing knowledge on the clinical significance RAM and DOC following combined chemoimmunotherapy is limited. Therefore, we evaluated efficacy safety after attempted identify predictors its outcomes. Patients Methods This multicenter,...
Recently, novel Kirsten rat sarcoma viral oncogene homolog (KRAS) inhibitors have been clinically developed to treat KRAS G12C-mutated non-small cell lung cancer (NSCLC) patients. However, achieving complete tumor remission is challenging. Therefore, the optimal combined therapeutic intervention with G12C has a potentially crucial role in clinical outcomes of We investigated underlying molecular mechanisms adaptive resistance NSCLC cells devise strategy preventing drug-tolerant emergence....
Optically induced mechanical angular alignment of trapped birefringent micrometer-sized objects resulting from the transfer momentum produced by birefringence using linearly polarized light has been experimentally demonstrated. Fluorinated polyimide (PMDA/TFDB) micro-objects having a large $\ensuremath{\Delta}{n=n}_{\mathrm{slow}}\ensuremath{-}{n}_{\mathrm{fast}}=0.13$ (refractive indices ${n}_{\mathrm{slow}}=1.62,$ ${n}_{\mathrm{fast}}=1.49),$ which were fabricated micromachining (reactive...
The cross sections of the Be7(n,α)He4 reaction for p-wave neutrons were experimentally determined at Ec.m.=0.20–0.81 MeV slightly above big bang nucleosynthesis (BBN) energy window first time on basis detailed balance principle by measuring time-reverse reaction. obtained are much larger than s-wave inferred from recent measurement n_TOF facility in CERN, but significantly smaller theoretical estimation widely used BBN calculations. present results suggest rate is not large enough to solve...
Ultra-stripped supernovae (USSN) with a relatively low ejecta mass of $\sim0.1M_\odot$ (e.g., iPTF14gqr and SN2019dge) are considered to originate from ultra-stripped carbon-oxygen (CO) cores in close binary systems likely be progenitors neutron stars (BNSs). Here we conduct long-term simulations USSNe various masses ($1.45\,M_\odot \leq M_\mathrm{CO} 2.0\,M_\odot$) based on results neutrino-radiation hydrodynamics simulations, consistently calculate the nucleosynthesis SN light curves. We...
Abstract A novel approach is proposed to reveal a secret birth of enhanced circumstellar material (CSM) surrounding collapsing massive star using neutrinos as unique probe. In this scheme, nonthermal TeV-scale produced in ejecta–CSM interactions are tied with thermal MeV emitted from pre-explosion burning process, based on scenario that CSM had been formed via the presupernova activity. Taking representative model neutrinos, spectrum and light curve corresponding high-energy calculated at...
Abstract Simulations of presupernova evolution suggest that intense O-shell burning can be so active that, in extreme cases, it merge with the outer C-burning shell, changing initial conditions for supernova explosion. However, such violent activity interior stars has been difficult to confirm from observations stars. Here we propose elemental composition O-rich ejecta remnants (SNRs) a tool test this kind shell final stages progenitor evolution. As an example, discuss origin “Mg-rich” SNR...
Rising inequality and polarization of employment earnings have been clearly documented in Canada most other developed economies the 1990s. Following a critical discussion use Cini coefficient as measure geography, level social household incomes at census tract is assessed for Canada's 22 largest Census Metropolitan Areas. The distribution income among metropolitan tracts generally becoming more unequal. In addition, proportion households middle‐income declining centres, lending further...
We systematically measured the differential cross sections of inelastic α scattering off self-conjugate A=4n nuclei at two incident energies Eα=130MeV and 386MeV Research Center for Nuclear Physics, Osaka University. The were analyzed by distorted-wave Born-approximation (DWBA) calculation using single-folding potentials, which are obtained folding macroscopic transition densities with phenomenological αN interaction. DWBA density-dependent interaction overestimates ΔL=0 transitions....
Simulations of pre-supernova evolution suggest that some intense shell burning can be so active that, in extreme cases, it merge with the outer shell, changing initial conditions for supernova explosion. However, such violent activity interior stars has been difficult to confirm from observations stars. Here we propose elemental composition O-rich ejecta remnants a tool test this kind final stages progenitor evolution. As an example, discuss origin "Mg-rich" remnant N49B. A high Mg/Ne mass...
Abstract Lazertinib, a novel third‐generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‐TKI), demonstrates marked efficacy in EGFR‐mutant lung cancer. However, resistance commonly develops, prompting consideration of therapeutic strategies to overcome initial drug mechanisms. This study aimed elucidate the adaptive lazertinib and advocate combination treatments that demonstrate preventing as first‐line treatment for EGFR mutation‐positive NSCLC. We found AXL knockdown...
A strongly focused Nd:YAG laser beam has been used experimentally to achieve optical trapping and simultaneous rotation of a micro-object about an axis perpendicular the axis. The (12 μm in diameter), which shape anisotropy its interior, can be produced by oxygen reactive ion etching fluorinated polyimide film (refractive index n=1.53). This optically induced ethanol (n=1.36) is accomplished utilizing net radiation pressure force arising from momentum change light scattered at micro-object’s...
This paper describes an optical switching module based on microelectromechanical systems (MEMS) two-axis tilt mirror arrays and low-cost highly accurate free-space optics. The MEMS are integrated single-crystal silicon wafers provide reliable operation at a low driving voltage. optics consists of two-dimensional fiber microlens polymer-based components. They compact (approximately 80/spl times/60/spl times/35 mm [170 cc]) assembled passively by using dowel pins. A prototype switch with...
Fluorinated polyimide micro-objects having large birefringence of Δn=−0.13 (refractive index n1=1.62, n2=1.49 for the wavelength λ=1.06 μm), which were fabricated by reactive ion etching and suspended in water (n=1.33), trapped angularly aligned a single Gaussian laser beam (λ=1.06 μm, power P>3 μW). The optically induced angular alignment effect is caused transfer spin momentum due to interaction between their linearly polarized light.
We have developed a microlaser Doppler velocimeter in which the laser diode, photodiode, and optical waveguide are monolithically integrated on GaAs substrate. This integration eliminates difficult alignment susceptibility to environmental disturbances disadvantages of conventional velocimeter. Our showed good linearity between relative velocity output frequency, it can detect very low velocities less than 5 /spl mu/m/s. It also measure flow speed liquid containing particles. Moreover,...
We have developed a microlaser encoder that can detect displacements relative to an external grating scale with resolution on the order of 10 nm. Its size is only few tens percent conventional encoder's. A long-lasting InP laser diode wavelength 1550 nm was bonded, along several photodiode chips, within alignment accuracy 1 μm onto silicon planar lightwave circuit chip. The chip 2.3 mm × 1.7 and includes fluorinated polyimide lightwaveguide fabricated in advance. wide gap more than 600...
A novel integrated optical micro-encoder based on diffraction is presented, which can measure the relative distance traveled against a grating (scale) in vector direction. measurement resolution of less than 0.01 mu m possible. The encoder extremely small, only 500- square, 1/100 size conventional encoders. Therefore, be incorporated into micro-machine and moved at high speed, since its inertia low. This used even when gap between few hundred micrometers.< <ETX...
This paper describes improvements made to a single-crystal mirror actuated electrostatically by terraced electrodes with high-aspect ratio torsion spring. The are reduced pitch, increased size, and higher stability from the electrical viewpoint.