A5084249034- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Food Science and Nutritional Studies
- Advanced biosensing and bioanalysis techniques
- Cardiac Ischemia and Reperfusion
- Seed and Plant Biochemistry
- Cell death mechanisms and regulation
- Advances in Cucurbitaceae Research
- Education and Islamic Studies
- Drug-Induced Hepatotoxicity and Protection
- Quantum-Dot Cellular Automata
- Eicosanoids and Hypertension Pharmacology
- Supramolecular Self-Assembly in Materials
- Low-power high-performance VLSI design
- Drug Transport and Resistance Mechanisms
- Ion channel regulation and function
- Pancreatic function and diabetes
- RNA Interference and Gene Delivery
- Analog and Mixed-Signal Circuit Design
- Chemotherapy-induced cardiotoxicity and mitigation
- Religion, Society, and Development
- Adipose Tissue and Metabolism
- Liver physiology and pathology
- Mitochondrial Function and Pathology
Centre of Biomedical Research
2021-2025
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2021-2022
Chhattisgarh Kamdhenu Vishwavidyalaya
2014
Cardiotoxicity remains a major limiting factor in the clinical implementation of anthracycline chemotherapy. Though etiology doxorubicin-dependent heart damage has yet to be fully elucidated, ability doxorubicin DNA and trigger oxidative stress have been heavily implicated pathogenesis chemotherapy-associated cardiomyopathy. Here, we demonstrate that fibronectin type III domain-containing protein 5 (FNDC5), precursor for myokine irisin, is depleted hearts human cancer patients or mice...
The pathophysiological mechanism(s) driving non-alcoholic fatty liver disease, the most prevalent chronic disease globally, have yet to be fully elucidated. Here, we identify regulator of G protein signaling 6 (RGS6), up-regulated in livers NAFLD patients, as a critical mediator hepatic steatosis, fibrosis, inflammation, and cell death. Human patients with high RGS6 expression exhibited corresponding inflammatory burden, pronounced insulin resistance, poor function. In mice, liver-specific...
Dose-limiting cardiotoxicity remains a major limitation in the clinical use of cancer chemotherapeutics. Here, we describe role for Regulator G protein Signaling 7 (RGS7) chemotherapy-dependent heart damage, demonstration functional RGS7 outside nervous system and retina. Though expressed at low levels basally, observed robust up-regulation human murine myocardium following chemotherapy exposure. In ventricular cardiomyocytes (VCM), forms complex with Ca 2+ /calmodulin-dependent kinase...
Abstract Background Prior evidence demonstrated that Regulator of G protein Signaling 6 (RGS6) translocates to the nucleolus in response cytotoxic stress though functional significance this phenomenon remains unknown. Methods Utilizing vivo gene manipulations mice, primary murine cardiac cells, human cell lines and patient samples we dissect participation a RGS6-nucleolin complex chemotherapy-dependent cardiotoxicity. Results Here demonstrate RGS6 binds key nucleolar protein, Nucleolin,...
Development of drug carriers, which can chaperone xenobiotics directly to their site action, is an essential step for the advancement precision medicine. Cationic nanoparticles be used as a delivery platform various agents including chemotherapeutics, oligonucleotides, and antibodies. Self-assembly short peptides facilitates formation well-defined nanostructures suitable delivery, varying polarity self-assembly medium changes nature noncovalent interactions in such way generate numerous...
Aims: The pathophysiological mechanism(s) underlying non-alcoholic fatty liver disease (NAFLD) have yet to be fully delineated and only a single drug, peroxisome proliferator-activated receptor (PPAR) α/γ agonist saroglitazar, has been approved. Here, we sought investigate the role of Regulator G Protein Signaling 7 (RGS7) in hyperlipidemia-dependent hepatic dysfunction. Results: RGS7 is elevated livers NAFLD patients, particularly those with severe damage, pronounced insulin resistance,...
Excessive ingestion of the common analgesic acetaminophen (APAP) leads to severe hepatotoxicity. Here we identify G protein β5 (Gβ5), elevated in livers from APAP overdose patients, as a critical regulator cell death pathways and autophagic signaling APAP-exposed liver. Liver-specific knockdown Gβ5 mice protected liver APAP-dependent fibrosis, loss, oxidative stress, inflammation following either acute or chronic administration. Conversely, overexpression was sufficient drive hepatocyte...
In this paper, a d flip=flop is designed using Xilinx ISE design suite 14.2. The language used Verilog. flip flop FPGA based and will be dissipating the minimum amount of power. I/O standard here LVCMOS (Low Voltage Complementary Metal Oxide Semiconductor) which help us in achieving goal power dissipation. analysis done on different families like Artix-7, Spartan-3, Spartan-6, Virtex-6, Virtex-5. scaling frequency frequencies are 1 Ghz, 2 3 4 Ghz 5 Ghz.
Purpose – The present study was aimed to enhance the nutritional quality of veg bottle gourd balls by incorporating boiled mashed egg replacing guard in formulation batter. Design/methodology/approach Three different levels, viz. 50, 60 and 70 per cent whole were taken optimize level gourd. developed products evaluated for physico-chemical, proximate analysis sensory evaluation on Day 0, 3, 6 9 storage, whereas microbiological studies product conducted 1, 4, 7 10. Findings pH, cooking yield...