Grazielle de Fátima Pinto Rodrigues

ORCID: 0000-0003-4883-1332
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About
Contact & Profiles
Research Areas
  • Pregnancy and Medication Impact
  • Neonatal Respiratory Health Research
  • Assisted Reproductive Technology and Twin Pregnancy
  • Academic Research in Diverse Fields
  • Pregnancy and preeclampsia studies
  • Reproductive Health and Contraception
  • Renal function and acid-base balance
  • Asthma and respiratory diseases
  • Iron Metabolism and Disorders
  • Preterm Birth and Chorioamnionitis
  • Healthcare Regulation
  • Birth, Development, and Health
  • Maternal and Perinatal Health Interventions
  • Prenatal Substance Exposure Effects
  • Education Pedagogy and Practices
  • Eicosanoids and Hypertension Pharmacology
  • Infant Nutrition and Health
  • Youth, Drugs, and Violence
  • Fatty Acid Research and Health
  • Maternal and fetal healthcare
  • Business and Management Studies
  • Pediatric health and respiratory diseases

Universidade de São Paulo
2018-2024

Seevic College
2021

Universidade Nove de Julho
2020

Instituto de Filosofía
2017

Aim No study has evaluated the betamethasone pharmacokinetics in twin pregnancies according to chorionicity. This aimed describe and compare pharmacokinetic parameters singleton dichorionic (DC) monochorionic third trimester of pregnancy. Methods Twenty‐six pregnant women received 2 intramuscular doses 6 mg sodium phosphate plus acetate due preterm labour. Serial blood samples were collected for 24 hours after first dose esters. Betamethasone plasma concentrations quantified using a...

10.1111/bcp.15111 article EN British Journal of Clinical Pharmacology 2021-10-20

Clinical experience shows an increased duration of labor in obese parturient women. It is unclear if this population should receive the same dose vaginal misoprostol for induction as non-obese We investigate influence obesity on pharmacokinetics and placental transfer metabolite acid Parturient women (n = 40) were enrolled received 25 µg/6 h vaginally allocated into two groups according to pre-pregnancy body mass index (BMI <30 kg/m

10.1002/jcph.6166 article EN The Journal of Clinical Pharmacology 2024-11-26

Abstract Clinical and experimental studies show an association between maternal periodontitis adverse outcomes during gestation. On the other hand, there were no evaluating impact of on offspring. Thus, our objective was to investigate repercussion development asthma in Pregnant rats submitted or not by ligature technique. Thirty days after birth, puppies sensitized challenged with ovalbumin (OVA) order induce asthmatic response. Our results showed that reduced cellular infiltrate parenchyma...

10.1017/s2040174420000203 article EN Journal of Developmental Origins of Health and Disease 2020-04-21

Betamethasone (BET) is a synthetic glucocorticoid recommended for pregnant women at imminent risk of preterm birth before 34 weeks to reduce neonatal complications. There are different techniques describe BET plasma quantification. However, none quantified the plasmatic concentration in dichorionic (DC) twin pregnancies using LC-MS. Our objectives were develop and validate method quantifying by LC-MS pharmacokinetic (PK) placental transfer studies DC pregnancies. Blood samples collected...

10.1590/s2175-97902023e20314 article EN cc-by Brazilian Journal of Pharmaceutical Sciences 2023-01-01

Aims: No study has evaluated the BET pharmacokinetics in twin pregnancies separated by chorionicity. The aim this is to describe and compare pharmacokinetic parameters singleton, dichorionic (DC) monochorionic (MC) third trimester of pregnancy. Methods: Twenty-six pregnant women received an intramuscular dose 6 mg sodium phosphate plus acetate. Serial blood samples were collected for 24 hours after first esters dose. plasma concentrations quantified using a validated HPLC analytical method....

10.22541/au.161642855.55463866/v1 preprint EN Authorea (Authorea) 2021-03-22
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