A5101637775- Clinical Nutrition and Gastroenterology
- Infant Nutrition and Health
- Diet and metabolism studies
- Nutritional Studies and Diet
- Agriculture Sustainability and Environmental Impact
- Metabolism and Genetic Disorders
- Obesity, Physical Activity, Diet
- Nutrition and Health in Aging
- Birth, Development, and Health
- Pediatric Hepatobiliary Diseases and Treatments
- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Child Nutrition and Water Access
- Lymphatic Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Body Composition Measurement Techniques
- Vitamin D Research Studies
- Gout, Hyperuricemia, Uric Acid
- Folate and B Vitamins Research
- Child Nutrition and Feeding Issues
- Vascular Malformations and Hemangiomas
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Iron Metabolism and Disorders
- Infant Development and Preterm Care
Shanghai Jiao Tong University
2015-2025
XinHua Hospital
2015-2025
Shanghai Institute of Nutrition and Health
2014-2023
University School
2019
Jishou University
2016
Shanghai Children's Medical Center
2008
Shanghai Clinical Research Center
2008
The aim of this study was to determine the effect antioxidant vitamin E (VE) on adiponectin and leptin expression in obese rats. Thirty weaning male Sprague–Dawley rats were divided into three groups as follows: (1) a control group, fed with normal chow; (2) diet-induced obesity group (DIO), high-fat diet (3) an intervention supplemented VE (350 mg/kg). After 10 weeks being according these assignments, weighed euthanized. Blood adipose tissues then immediately collected; mRNA protein levels...
Choline plays a lipotropic role in lipid metabolism as an essential nutrient. In this study, we investigated the effects of choline (5, 35 and 70 μM) on DNA methylation modifications, mRNA expression critical genes their enzyme activities involved hepatic metabolism, mitochondrial membrane potential (Δψm) glutathione peroxidase (GSH-Px) C3A cells exposed to excessive energy substrates (lactate, 10 mM; octanoate, 2 mM pyruvate, 1 lactate, octanoate pyruvate-supplemented medium (LOP)). Thirty...
Previous studies have shown that bovine lactoferrin (bLF) exerts antibacterial, immune-modulating and anti-inflammatory effects. The present study aimed to investigate the effect of enteral bLF supplementation on intestinal adaptation barrier function in a rat model short bowel syndrome (SBS). Male Sprague–Dawley rats aged 4 weeks were randomised into three groups (n 10 per group): Sham group (rats submitted transection reanastomosis); SBS 80 % small-bowel resection); SBS-bLF resection plus...
This study aimed to evaluate whether serum uric acid (SUA) plays a mediating role in the development of insulin resistance (IR) obese children and adolescents.A total 369 participants aged 4-17 years with obesity who attended Nutrition Outpatient Clinic for Obesity at Xinhua Hospital from January 2012 2019 were recruited this retrospective study. We classified into two groups on basis HOMA-IR values: low group (< 3.16) (n = 222) high (≥ 147).The univariate analysis found that had higher BMI,...
Abstract Background The early‐life gut microbiota, which is critically important for the long‐term health of infants, normally sensitive to perturbations, especially in preterm infants. However, how microbiota develops and what key factors affect remain largely unknown. We hypothesized that microbial dysbiosis exists from beginning after birth, alteration associated with parenteral nutrition antibiotic therapy interventions. Methods Fecal samples were collected fifty‐one fifty full‐term...
This study aimed to investigate the respiratory quotient (RQ) levels and its trend in early postoperative period of patients with heart disease. Additionally, we explored factors influencing RQ evaluated predictive capabilities lactic acid for various outcomes. In this prospective observational study, participants included were disease aged 18-80 years who underwent elective open-heart surgery subsequently admitted cardiothoracic ICU post-operation. Indirect calorimetry (IC) measurements...
Abstract Objective To assess the incidence of extrauterine growth restriction (EUGR) in very low‐birth‐weight infants (VLBWIs) and evaluate nutrition factors VLBWIs associated with inadequate nutrient intakes during hospitalization. Methods A total 128 were divided into an EUGR group (n = 87) a non‐EUGR 41). Growth parenteral (PN) enteral (EN) practices analyzed. Actual energy protein subtracted from recommended (120 kcal/kg/d) (3.75 g/kg/d) intakes, deficits calculated. Results was 21.9% at...
Abstract Background The relationship between vitamin D and diabetes peripheral neuropathy (DPN) is not consistent among epidemiologic studies. Thus, we aimed to investigate this in different age groups. Methods In cross‐sectional study, 1461 patients admitted the Department of Endocrinology at Xinhua Hospital from June 2016 September 2017 were divided into three groups: a Youth group (24‐44 years, n = 127), Middle‐age (45‐64 779), an Elderly (≥65 555). Basic information laboratory results...
Purpose: To explore the relationships between serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP) levels and glucolipid metabolism disorders (GLMD) in obese children adolescents. Patients Methods: In this cross-sectional study, 105 adolescents were selected for detection of TNF-α, IL-6, hs-CRP, glycolipid indicators. All participants divided into elevated TNF-α group (≥ 8.1 pg/mL; n=49) normal (< n=56), IL-6 5.9 n=13) n=92), hs-CRP 3.0...
It is still unclear if and at which trimester gestational weight gain related to childhood adiposity. Thus we aimed evaluate the association between trimester-specific body-fat compositions in Chinese children. Maternal were measured by trained nurses every 2 4 weeks from first prenatal care, of 407 children Shanghai Obesity Cohort 5 years age nutritionist through bioelectrical impedance analysis. Overweight/obesity was defined according criteria International Task Force. Logistic linear...
Obesity has been reported to be an important contributing factor for precocious puberty, especially in girls. The effect of green tea polyphenols on weight reduction adult population shown, but few related studies have conducted children. This study was performed examine the effectiveness and safety decaffeinated (DGTP) ameliorating obesity early sexual development girls with obesity.This is a double-blinded randomized controlled trial. Girls aged 6-10 years old were randomly assigned...
Background: The pathogenesis of parenteral nutrition–associated cholestasis (PNAC) has not been clarified. objective this study was to explore the incidence PNAC in premature infants without surgery and identify associated risk factors. Materials Methods: Premature neonates who received nutrition (PN) at least 14 days were included a retrospective, dual‐center study. Cholestasis diagnosed as conjugated bilirubin ≥2 mg/dL. Infants with metabolic liver disease, cyanotic congenital heart...
Abstract Background The milk fat globule membrane (MFGM) contains various bioactive components which have been shown to maintain gut barrier integrity. This study aimed evaluate the protective effects of MFGM on intestinal function and its possible mechanisms in a rat model short bowel syndrome (SBS). Materials Methods Five‐week‐old male Sprague‐Dawley rats were divided into 3 groups (n = 8 per group), consisting Sham group submitted massive small‐bowel resection then supplemented with...
Clinical research reveals that colon plays an important role in mitigating the effects of short-bowel syndrome (SBS). Previously, we showed milk fat globule membrane (MFGM) had protective on gut barrier integrity rat SBS model. Here, used same model to investigate enteral MFGM supplementation microbiota and colonic-mucus-barrier function its related mechanisms.We randomly divided 24 male Sprague-Dawley rats into 3 groups: Sham, (rats with massive small-bowel resection), SBS+MFGM (SBS...
Abstract Background In a cohort of hospitalized children with congenital heart disease (CHD), new digital pediatric malnutrition screening tool as mobile application was validated, and its effectiveness clinical value were determined prospective study. Methods results Children CHD ( n = 1125) screened for risk. The incidence risk the differences among various age groups types characterized. optimal threshold to determine if there is score 2, while Youden index 79.1%, sensitivity specificity...
The goals of this study were to investigate the difference in carotid arterial stiffness obese children compared healthy and correlation between parameters obesity using ultrasound (US) radiofrequency (RF) data technology. Carotid artery parameters, including compliance coefficient, index, pulse wave velocity, evaluated 71 patients 47 controls with US RF In addition, all participants for fat thickness paraumbilical abdominal wall fatty liver US. Compared control group, blood pressure (BP),...