A5012936051- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- Telomeres, Telomerase, and Senescence
- Pancreatic and Hepatic Oncology Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Caveolin-1 and cellular processes
- DNA Repair Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Epigenetics and DNA Methylation
- Protein Kinase Regulation and GTPase Signaling
- Genetic and Kidney Cyst Diseases
- Atherosclerosis and Cardiovascular Diseases
- Genomics and Chromatin Dynamics
- Advanced Breast Cancer Therapies
- Cytokine Signaling Pathways and Interactions
- PI3K/AKT/mTOR signaling in cancer
- FOXO transcription factor regulation
Mayo Clinic in Florida
2020-2023
WinnMed
2019
Mayo Clinic
2019
Abstract Super-enhancers regulate genes with important functions in processes that are cell type-specific or define identity. Mouse embryonic fibroblasts establish 40 senescence-associated super-enhancers regardless of how they become senescent, 50 activated located the vicinity these enhancers. Here we show, through gene knockdown and analysis three core biological properties senescent cells a relatively large number super-enhancer-regulated promote survival mouse fibroblasts. Of these,...
A homozygous truncating frameshift mutation in CEP57 (CEP57T/T) has been identified a subset of mosaic-variegated aneuploidy (MVA) patients; however, the physiological roles centrosome-associated protein that contribute to disease are unknown. To investigate these, we have generated mouse model mimicking this mutation. Cep57T/T mice died within 24 hours after birth with short, curly tails and severely impaired vertebral ossification. Osteoblasts lumbosacral vertebrae were deficient for Fgf2,...
Abstract PTEN is a multifaceted tumor suppressor that highly sensitive to alterations in expression or function. The C-tail domain, which rich phosphorylation sites, has been implicated stability, localization, catalytic activity, and protein interactions, but its role tumorigenesis remains unclear. To address this, we utilized several mouse strains with nonlethal mutations. Mice homozygous for deletion includes S370, S380, T382 T383 contain low levels hyperactive AKT are not prone. Analysis...