A5085136679- Immune Cell Function and Interaction
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Autoimmune and Inflammatory Disorders Research
- Pluripotent Stem Cells Research
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Microgrid Control and Optimization
- Reproductive System and Pregnancy
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Health and Well-being Studies
- CRISPR and Genetic Engineering
Kanazawa University
2021-2022
Mongolian National University
2019-2021
Mongolian National University of Medical Sciences
2016-2021
Technical University of Munich
2019-2021
Klinikum rechts der Isar
2019
RIKEN Center for Integrative Medical Sciences
2007-2017
Immune Regulation (United Kingdom)
2009-2015
Hokkaido University
2003-2007
Invariant Vα14 natural killer T (NKT) cells, characterized by the expression of a single invariant cell receptor (TCR) α chain encoded rearranged Trav11 (Vα14)-Traj18 (Jα18) gene segments in mice, and TRAV10 (Vα24)-TRAJ18 humans, mediate adjuvant effects to activate various effector types both innate adaptive immune systems that facilitates potent antitumor effects. It was recently reported Jα18-deficient mouse described our group 1997 harbors perturbed TCRα repertoire, which raised concerns...
Current tumor therapies, including immunotherapies, focus on passive eradication or at least reduction of the mass. However, cancer patients quite often suffer from relapse metastasis after such treatments. To overcome these problems, we have developed a natural killer T (NKT) cell-targeted immunotherapy focusing active engagement patient's immune system, but not directly targeting cells themselves. NKT express an invariant antigen receptor α chain encoded by Trav11 (Vα14)-Traj18 (Jα18) gene...
It is well known that CD1d-restricted Valpha14 invariant natural killer T (NKT) cells are derived from in the CD4(+)CD8(+) double-positive (DP) population thymus. However, developmental progression of NKT earlier stages remains unclear, and possible existence cell presursors than DP stage to be tested.Here, we demonstrate precursors express Valpha14-Jalpha18 transcripts but devoid surface expression receptor present late CD4(-)CD8(-) double-negative (DN)4 have potential generate mature both...
Two natural killer T (NKT)-cell hybridomas were established by fusing sorted NKT cells with BW1100 thymoma cells. The first hybridoma line, 1B6, was CD4+8-, whereas the second one, 2E10, CD4low8-. Initial characterizations revealed that both cell lines expressed an invariant antigen receptor, which could be readily detected α-galactosylceramide-loaded CD1d : Ig fusion protein (α-GalCer/CD1d). Sequence analyses of α and β chains receptor V genes 1B6 2E10 Vα14Jα18/Vβ8.2Dβ2Jβ2.7...
Summary The expression of allograft inflammatory factor‐1 (AIF‐1) in 2,4,6‐trinitrobenzene sulphonic acid (TNBS)‐induced colitis, a model for T helper 1 (Th1) type disease, was investigated BALB/c mice. AIF‐1 significantly increased the colitis lesion compared to that normal colon. We then prepared transgenic mice (Tgm) with background express high levels lymphoid tissues and When Tgm were administrated TNBS, TNBS‐induced ameliorated non‐transgenic littermates. amelioration associated low...
Immune reactions provoked by cerebral ischemia play crucial roles in the pathogenesis of brain damage and contribute to tissue regeneration processes. While functions many immune cell types post-ischemic inflammation have been well studied experimental stroke, exact played unconventional T cells clinical stroke remain be precisely determined. In present study, we investigated frequencies absolute numbers peripheral blood lymphocyte subpopulations including those invariant natural killer...
Abstract NKT cells are characterized by their expression of an NKT-cell-specific invariant antigen-receptor α chain encoded Vα14Jα18 gene segments. These bridge the innate and acquired immune systems to mediate effective augmented responses; however, limited number in vivo hampers analysis. Here, two lines induced pluripotent stem cell-derived mice (NKT-iPSC-derived mice) were generated reprogramming mature cells, where one harbors both rearranged Vβ7 genes other carries on alleles but...
Objectives: We aimed to analyze theassociation between the biophysiological characteristics of body constitution and temperament type with Mongolian Traditional Medicine (MTM) understand further integrate application these stratification systems in clinical medicine. Methods: Body was classified using body-mass index, determined personality test, dominant MTM 287 active blood donors. Age, gender, ABO groups were considered as additional characteristics. The correlation nature their...