A5014090332- Craniofacial Disorders and Treatments
- Dermatology and Skin Diseases
- Cleft Lip and Palate Research
- Psoriasis: Treatment and Pathogenesis
- Autoimmune Bullous Skin Diseases
- Dermatologic Treatments and Research
- Skin Protection and Aging
- Angiogenesis and VEGF in Cancer
- Nonmelanoma Skin Cancer Studies
- Hair Growth and Disorders
- Cardiac Valve Diseases and Treatments
- Nail Diseases and Treatments
- Peripheral Artery Disease Management
- Head and Neck Surgical Oncology
- Acne and Rosacea Treatments and Effects
- Mesenchymal stem cell research
- Asthma and respiratory diseases
- Cutaneous lymphoproliferative disorders research
- Language Development and Disorders
- Facial Rejuvenation and Surgery Techniques
- Aortic aneurysm repair treatments
- Health Systems, Economic Evaluations, Quality of Life
- Surgical Sutures and Adhesives
- Biomedical Ethics and Regulation
- Dental Anxiety and Anesthesia Techniques
Icahn School of Medicine at Mount Sinai
2016-2022
Mount Sinai Hospital
2021
Yale University
2011-2020
Mount Sinai Hospital
2020
University of Notre Dame
2020
Gallagher (United States)
2020
Plastic Surgery Hospital
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Academy of Medical Sciences
2019
Mount Sinai Medical Center
2018
Premature fusion of the cranial sutures (craniosynostosis), affecting 1 in 2000 newborns, is treated surgically infancy to prevent adverse neurologic outcomes. To identify mutations contributing common non-syndromic midline (sagittal and metopic) craniosynostosis, we performed exome sequencing 132 parent-offspring trios 59 additional probands. Thirteen probands (7%) had damaging de novo or rare transmitted SMAD6, an inhibitor BMP - induced osteoblast differentiation (p<10-20). SMAD6...
Background: The relationship between surgical age and long-term neuropsychological outcomes in sagittal-suture craniosynostosis remains equivocal. Whole-vault cranioplasty strip craniectomy are performed at various times individuals with craniosynostosis. This study used comprehensive neurological testing to examine the time of surgery function. Methods: Seventy patients who had previously undergone either whole-vault or were examined divided into three groups: treatment before 6 months (n =...
The optimal type of surgical management for isolated sagittal synostosis remains a source significant debate. There is paucity data regarding possible differences in long-term neuropsychological outcomes following treatment with whole-vault cranioplasty or endoscopic strip craniectomy. This study provides the first comparative analysis examining effects two techniques related to intellectual functioning.A total 70 patients were enrolled this multicenter study, 29 whom had previously...
Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, has demonstrated superior efficacy to ustekinumab in the phase 3b CLEAR study of moderate severe plaque psoriasis. Here, we report 16-week results from CLARITY, second head-to-head trial comparing secukinumab with ustekinumab.In CLARITY study, patients were randomized 1:1 receive subcutaneous 300 mg or per label. The co-primary objectives demonstrate superiority over at Week 12 relation proportion (1) 90% more improvement...
Characterizing blood profile of alopecia areata (AA) is important not only for treatment advancements, but also possibly identifying peripheral biomarkers that will eliminate the need scalp biopsies. We aimed to compare frequencies skin homing (CLA+ ) vs systemic (CLA- "polar" CD4+ and CD8+ activated T-cell subsets in AA atopic dermatitis (AD) control blood.Flow cytometry was used measure IFN-γ, IL-13, IL-9, IL-17, IL-22 cytokines T cells. Inducible co-stimulator molecule (ICOS) HLA-DR were...
Abstract Background Secukinumab demonstrated superior efficacy over ustekinumab in the treatment of moderate to severe plaque psoriasis 16 weeks CLARITY study and 52 CLEAR study. Objective To compare safety secukinumab vs. CLARITY. Methods Analysis 52‐week data from (NCT02826603), a phase 3b which patients were randomized receive 300 mg ( n = 550) or 45/90 552) per label. Results At week 52, was proportion who achieved ≥ 90% improvement Psoriasis Area Severity Index (73.2% 59.8%; odds ratio...
Background: In recent years, metopic synostosis has represented up to 25 percent of all nonsyndromic craniosynostosis cases, manifesting with varying degrees trigonocephaly. It is unknown whether the degree severity anterior dysmorphology proportionate neurologic dysfunction. This knowledge essential guide future surgical treatment recommendations. Given reported correlation abnormal auditory processing language dysfunction and poorer academic performance in patients, present study aims...
Crouzon syndrome is associated with severe respiratory impairment of the upper airway due in part to midfacial dysmorphology. We calculated distinctive nasal diameter and pharyngeal volume patients compared them age-matched control subjects.Children computed tomography scans absence surgical intervention were included. Computed digitized manipulated using Surgicase CMF (Materialise). Craniometric data relating midface collected. For all linear measurements, mean percent increases or...
Background: Apert syndrome is frequently combined with respiratory insufficiency, because of the midfacial deformity which, in turn, influenced by malformation skull base. Respiratory impairment resulting from caused multilevel limitations airway space. Therefore, this study evaluated segmented nasopharyngeal and laryngopharyngeal anatomy to clarify subcranial children its relevance clinical management. Methods: Twenty-seven patients (Apert syndrome, n = 10; control, 17) were included. All...
Background Patients with single-suture craniosynostosis (SSC) are at an elevated risk for long-term learning disabilities. Such adverse outcomes indicate that the early development of neural processing in SSC may be abnormal. At present, however, precise functional derangements developing brain remain largely unknown. Event-related potentials (ERPs) a form noninvasive neuroimaging provide direct measurements cortical activity and have shown value predicting cognitive functioning. The current...