A5058473872- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Histone Deacetylase Inhibitors Research
- CNS Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Soft tissue tumor case studies
- Protein Degradation and Inhibitors
- MicroRNA in disease regulation
- Radiomics and Machine Learning in Medical Imaging
- Advances in Oncology and Radiotherapy
- Animal Vocal Communication and Behavior
- Adrenal and Paraganglionic Tumors
- Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Aquatic life and conservation
- Mental Health and Psychiatry
- Reconstructive Surgery and Microvascular Techniques
- Anatomy and Medical Technology
- Facial Trauma and Fracture Management
- Pituitary Gland Disorders and Treatments
- Pelvic and Acetabular Injuries
- Global Health Workforce Issues
Oregon Health & Science University
2018-2025
Neurological Surgery
2018-2024
Harvard Global Health Institute
2024
Harvard University
2023-2024
Columbia University
2017-2018
Brown University
2015-2018
Columbia University Irving Medical Center
2018
Northwestern University
2018
Providence College
2017
Emory University
2012
O6-methylguanine-DNA methyltransferase (MGMT [OMIM 156569]) promoter methylation (mMGMT) is predictive of response to alkylating chemotherapy for glioblastomas and routinely used guide treatment decisions. However, the utility MGMT status low-grade anaplastic gliomas remains unclear due molecular heterogeneity lack sufficiently large data sets.
Abstract BACKGROUND Cytoreductive surgery is considered controversial for primary central nervous system lymphoma (PCNSL). OBJECTIVE To investigate survival following craniotomy or biopsy PCNSL METHODS The National Cancer Database-Participant User File (NCDB, n = 8936), Surveillance, Epidemiology, and End Results Program (SEER, 4636), an institutional series (IS, 132) were used. We retrospectively investigated the relationship between craniotomy, prognostic factors, using case–control...
Abstract Purpose: While MGMT promoter methylation (mMGMT) is predictive of response to alkylating chemotherapy and guides treatment decisions in glioblastoma, its role grade 2 3 glioma remains unclear. Recent data suggest that mMGMT prognostic progression-free survival 1p/19q-codeleted oligodendrogliomas, but an effect on overall (OS) has not been demonstrated. Experimental Design: We identified patients with newly diagnosed gliomas known status the National Cancer Database from 2010 2019....
OBJECTIVE Whether obesity is associated with meningioma and the impact of by gender has been debated. The primary objective this study was to investigate differences in BMI between male female patients undergoing craniotomy for compare those other intracranial tumors. secondary location progression-free survival (PFS) obese nonobese a multi-institutional cohort. METHODS National data were obtained from Surgical Quality Improvement Program (NSQIP) database. Male analyzed separately. Patients...
Genomic analysis in neurooncology has underscored the importance of understanding patterns survival different molecular subtypes within gliomas and their responses to treatment. In particular, diffuse are now principally characterized by mutation status (IDH1 1p/19q codeletion), yet there remains a paucity information regarding prognostic value markers extent resection (EOR) on survival. Furthermore, given modern emphasis rather than histological diagnosis, it is important examine effect...
Solitary fibrous tumor/hemangiopericytoma (SFT/HPC) of the central nervous system (CNS) is a rare meningeal tumor. Given absence prospective or randomized data, there are no standard indications for radiotherapy. Recently, NRG Oncology and EORTC cooperative groups successfully accrued completed first trials evaluating risk-adapted adjuvant radiotherapy strategies meningiomas. Using similar framework, we sought to develop prognostic risk categories that may predict survival benefit associated...
Catecholaminergic (CA) neurons innervate sensory areas and affect the processing of signals. For example, in birds, CA fibers auditory pathway at each level, including midbrain, thalamus, forebrain. We have shown previously that female European starlings, activity forebrain can be enhanced by exposure to attractive male song for one week. It is not known, however, whether hearing initiate more rapidly. Here, we exposed estrogen-primed, white-throated sparrows conspecific looked evidence...
Many patients treated with stereotactic radiosurgery (SRS) alone as initial treatment require 1 or more subsequent salvage therapies. This study aimed to determine if commonly used strategies are associated differing risks of radiation necrosis (RN). All upfront SRS for brain metastases at our institution were retrospectively analyzed. Salvage details obtained failures. Patients who underwent repeat the same lesion excluded. RN was determined based on pathological confirmation advanced...
Objective: Recent studies of primary central nervous system lymphoma (PCNSL) have found a positive association between cytoreductive surgery and survival, challenging the traditional notion that is not beneficial potentially harmful. However, no examined potential added benefits adjuvant treatment in post-operative setting. Here, we investigate survival PCNSL patients treated with plus radiation therapy (RT).Methods: The Surveillance, Epidemiology, End-Results Program was used to identify...
BACKGROUND AND OBJECTIVES: Cranioplasty infections are a common and expensive problem associated with significant morbidity. Our objective was to determine whether wound healing protocol after cranioplasty reduced the rate of value this intervention. METHODS: This is single-institution retrospective chart review 2 cohorts patients over 12 years. The protocol, consisting vitamin mineral supplementation, fluid oxygen support, instituted for all aged older than 15 years undergoing cranioplasty....
The purpose of this study is to examine the utilization kyphoplasty/vertebroplasty procedures in management compression fractures. With growing elderly population and associated increase rates osteoporosis, vertebral fractures have become a daily encounter for spine surgeons. However, there remains lack consensus on optimal patient population.