A5044567267- Viral gastroenteritis research and epidemiology
- Streptococcal Infections and Treatments
- Toxin Mechanisms and Immunotoxins
- Clostridium difficile and Clostridium perfringens research
- Transgenic Plants and Applications
- Otolaryngology and Infectious Diseases
- Inflammasome and immune disorders
- Salmonella and Campylobacter epidemiology
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Leptospirosis research and findings
- Neonatal and Maternal Infections
- Vibrio bacteria research studies
- Respiratory viral infections research
- Bacteriophages and microbial interactions
- Mycobacterium research and diagnosis
- Bacterial Identification and Susceptibility Testing
- Bacterial Infections and Vaccines
- Infective Endocarditis Diagnosis and Management
Emory University
2020-2023
St. Jude Children's Research Hospital
2023
Arizona State University
2017-2019
Necrotic enteritis is an economically important poultry disease caused by the bacterium Clostridium perfringens. There are currently no necrotic vaccines commercially available for use in broiler birds, most target population. Salmonella-vectored represent a convenient and effective option controlling this disease. We used single attenuated Salmonella vaccine strain, engineered to lyse within host, deliver up three C. perfringens antigens. Two of antigens were toxoids, based on α-toxin NetB...
Group A
ABSTRACT Salmonella enterica serovar Typhi causes the systemic disease typhoid fever. After ingestion, it adheres to and invades host epithelium while evading innate immune response, causing little if any inflammation. Conversely, Typhimurium gastroenteritis in humans thrives inflamed gut. Upon entering host, S . preferentially colonizes Peyer's patches, a lymphoid organ which microfold cells (M cells) overlay an arrangement of B cells, T antigen-presenting cells. Both serovars can adhere...
Necrotic enteritis (NE) is caused by type A strains of the bacterium Clostridium perfringens. Total global economic losses to poultry industry due NE estimated be over two billion dollars annually. Traditionally, has been effectively controlled inclusion antibiotics in diet poultry. However, recent concerns regarding impact this practice on increasing antibiotic resistance human pathogens have led us consider alternative approaches, such as vaccination, for controlling disease. C....
ABSTRACT The pro-inflammatory cytokine IL-6 regulates antimicrobial responses that are broadly crucial in the defense against infection. Our prior work shows promotes killing of M4 serotype group A Streptococcus (GAS) but does not impact globally disseminated M1T1 associated with invasive infections. Using vitro and vivo infection models, we show induces phagocyte reactive oxygen species (ROS) responsible for differential susceptibility GAS to IL-6-mediated defenses. Clinical isolates...
Invasive group A Streptococcus (GAS) in immunocompetent individuals is largely linked to hypervirulent strains. Congenital immunodeficiencies and those acquired from chronic disease or immunosuppressant drugs also increase risk of severe illness. We recovered GAS the blood a patient receiving biologic inhibitor interleukin 6 (IL-6). Growth this serotype M4 isolate human murine bacteremia model was promoted by 1 IL-6 inhibition. Hyperinvasive M1T1 unaffected both models. These findings based...
ABSTRACT Group A Streptococcus (GAS) is the etiologic agent of numerous high morbidity and mortality diseases which commonly have a highly proinflammatory pathology. One factor contributing to this inflammation GAS protease SpeB, directly activates cytokine interleukin-1β (IL-1β), independent canonical inflammasome pathway. IL-1β drives neutrophil activation recruitment that limits bacterial growth invasion during invasive skin soft tissue infections like necrotizing fasciitis. also causes...
Necrotic enteritis is an economically important poultry disease caused by the bacterium Clostridium perfringens. There are currently no necrotic vaccines available for use in broiler birds, most target population. Salmonella-vectored represent a convenient and effective option controlling this disease. We used single attenuated Salmonella vaccine strain, engineered to lyse within host, deliver up three C. perfringens antigens. Two of antigens were toxoids, based on ?-toxin NetB toxin. The...
Background . Necrotic enteritis (NE) is caused by type A strains of the bacterium Clostridium perfringens Total global economic losses to poultry industry due NE estimated be over 2 billion dollars annually. Traditionally, has been effectively controlled inclusion antibiotics in diet poultry. However, recent concerns regarding impact this practice on increasing antibiotic resistance human pathogens have led us consider alternative approaches, such as vaccination, for controlling disease. C....
Background . Necrotic enteritis (NE) is caused by type A strains of the bacterium Clostridium perfringens Total global economic losses to poultry industry due NE estimated be over 2 billion dollars annually. Traditionally, has been effectively controlled inclusion antibiotics in diet poultry. However, recent concerns regarding impact this practice on increasing antibiotic resistance human pathogens have led us consider alternative approaches, such as vaccination, for controlling disease. C....