A5001790737- Congenital Diaphragmatic Hernia Studies
- Congenital Anomalies and Fetal Surgery
- Neonatal Respiratory Health Research
- Hematopoietic Stem Cell Transplantation
- Prenatal Screening and Diagnostics
- Spinal Dysraphism and Malformations
- Mesenchymal stem cell research
- Virus-based gene therapy research
- Tracheal and airway disorders
- Teratomas and Epidermoid Cysts
- Fetal and Pediatric Neurological Disorders
- Reproductive System and Pregnancy
- Congenital Heart Disease Studies
- Urological Disorders and Treatments
- Organ and Tissue Transplantation Research
- Tumors and Oncological Cases
- Cerebrospinal fluid and hydrocephalus
- Pediatric Hepatobiliary Diseases and Treatments
- Hernia repair and management
- Pluripotent Stem Cells Research
- Neurogenetic and Muscular Disorders Research
- Assisted Reproductive Technology and Twin Pregnancy
- Intestinal Malrotation and Obstruction Disorders
- T-cell and B-cell Immunology
- Tissue Engineering and Regenerative Medicine
Children's Hospital of Philadelphia
2016-2025
University of Pennsylvania
2014-2023
Fetal Medicine Foundation
2023
University College London
2022
University College Hospital
2022
Children's Center
2009-2020
John Wiley & Sons (United Kingdom)
2018-2020
Hudson Institute
2018-2020
Philadelphia University
2005-2019
Abramson Center for Jewish Life
2019
Abstract In the developed world, extreme prematurity is leading cause of neonatal mortality and morbidity due to a combination organ immaturity iatrogenic injury. Until now, efforts extend gestation using extracorporeal systems have achieved limited success. Here we report development system that incorporates pumpless oxygenator circuit connected fetus lamb via an umbilical cord interface maintained within closed ‘amniotic fluid’ closely reproduces environment womb. We show fetal lambs are...
Fetal myelomeningocele (fMMC) repair has become accepted as a standard of care option in selected circumstances. We reviewed our outcomes for fMMC from referral and evaluation through surgery, delivery neonatal discharge.All patients referred potential were January 1, 2011 March 7, 2014. Maternal data collected on the 100 who underwent surgery.29% those evaluated met criteria (100 cases). The average gestational age was 21.9 weeks at 23.4 repair. Complications included membrane separation...
EVERE combined immunodeficiency is a congenital syndrome due to various genetic abnormalities that cause susceptibility infection, failure thrive, lymphoid hypoplasia, very low levels of T lymphocytes, and hypogammaglobulinemia. 1,2Untreated, the disorder usually fatal within first year life.We report successful treatment fetus with X-linked variant severe by in utero transplantation paternal bone marrow was enriched hematopoietic cell progenitors.
Hemopoietic stem cells from human fetal liver were transplanted in utero into preimmune sheep (48-54 days of gestation). The fate donor was followed using karyotype analysis, by immunofluorescence labeling with anti-CD antibodies, and fluorescent situ hybridization human-specific DNA probes. Engraftment occurred 13 33 recipients. Of five live born that exhibited chimerism, all expressed the marrow, whereas three them blood as well. multilineage (erythroid, myeloid, lymphoid) hemopoietic...
Transplantation of normal, immature, fetal hematopoietic cells into a preimmune recipient with congenital hemoglobinopathy may allow partial reconstitution normal hemoglobin production without the complications associated postnatal bone marrow transplantation (immunosuppression and occurrence graft versus host disease). In order to test this hypothesis naturally occurring polymorphism at β-hemoglobin locus sheep was used as marker for engraftment chimerism. Intraperitoneal injection...