A5025626597- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Functional Brain Connectivity Studies
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
- Data Analysis with R
- Semantic Web and Ontologies
- Machine Learning and Data Classification
- Advanced Wireless Communication Techniques
- Evolutionary Algorithms and Applications
- EEG and Brain-Computer Interfaces
- Advanced Data Compression Techniques
- Advanced Memory and Neural Computing
- Economic and Financial Impacts of Cancer
- Music and Audio Processing
- Color Science and Applications
- Radiomics and Machine Learning in Medical Imaging
- Memory Processes and Influences
- Machine Learning in Healthcare
- Advanced Neuroimaging Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Digital Filter Design and Implementation
- Seismic Imaging and Inversion Techniques
University of Birmingham
2019-2023
Radboud University Nijmegen
2013-2022
Current theories propose that coherence of oscillatory brain activity in the gamma band (30–80 Hz) constitutes an avenue for communication among remote neural populations. However, reports documenting stimulus dependency and time variability frequency suggest distant neuronal populations may, at any one time, operate different frequencies precluding synchronization. To test this idea, we recorded from macaque V1 V2 simultaneously while presenting gratings varying contrast. Although increased...
Abstract The hippocampus is an essential hub for episodic memory processing. However, how human hippocampal single neurons code multi-element associations remains unknown. In particular, it debated whether each neuron represents invariant element within episode or bind together all the elements of a discrete memory. Here we provide evidence latter hypothesis. Using single-neuron recordings from total 30 participants, show that individual neurons, which term episode-specific memories using...
Abstract Memory formation and reinstatement are thought to lock the hippocampal theta rhythm, predicting that encoding retrieval processes appear rhythmic themselves. Here, we show rhythmicity can be observed in behavioral responses from memory tasks, where participants indicate, using button presses, timing of recall cue-object associative memories. We find no evidence for presses visual tasks same stimuli, or questions about already retrieved objects. The oscillations correctly remembered...
Theta and gamma oscillations in the medial temporal lobe are suggested to play a critical role for human memory formation via establishing synchrony neural assemblies. Arguably, such facilitates efficient information transfer between neurons enhances synaptic plasticity, both of which benefit episodic formation. However, date little evidence exists from humans that would provide direct specific theta Here, we investigate how shape structure firing during lobe. We measured local field...
Abstract The processing steps that lead up to a decision, i.e., the transformation of sensory evidence into motor output, are not fully understood. Here, we combine stereoEEG recordings from human cortex, with single-lead and time-resolved decoding, using wide range temporal frequencies, characterize decision during rule-switching task. Our data reveal contribution rostral inferior parietal lobule (IPL) regions, in particular PFt, opercular regions demonstrate network representing is common...
Abstract Neural circuits contain a wide variety of interneuron types, which differ in their biophysical properties and connectivity patterns. The two most common parvalbumin-expressing somatostatin-expressing cells, have been shown to be differentially involved many cognitive functions. These cell types also show different relationships with the power phase oscillations local field potentials. mechanisms that underlie emergence oscillatory rhythms neural more than one subtype, roles specific...
Communication between cortical sites is mediated by long-range synaptic connections. However, these connections are relatively static, while everyday cognitive tasks demand a fast and flexible routing of information in the brain. Synchronization activity distant has been proposed as mechanism underlying such dynamic communication structure. Here, we study how oscillatory affects excitability input-output relation local circuits it alters transmission circuits. To this end, develop model...
Coherence is a widely used measure to determine the frequency-resolved functional connectivity between pairs of recording sites, but this confounded by shared inputs pair. To remove inputs, 'partial coherence' can be computed conditioning spectral matrices pair on all other recorded channels, which involves calculation matrix (pseudo-) inverse. It has so far remained challenge use time-resolved partial coherence analyze intracranial recordings with large number sites. For instance,...
Abstract Theta and gamma oscillations in the medial temporal lobe are suggested to play a critical role for human memory formation via establishing synchrony neural assemblies. Arguably, such facilitates efficient information transfer between neurons enhances synaptic plasticity, both of which benefit episodic formation. However, date little evidence exists from humans that would provide direct specific theta Here we investigate how shape structure firing during lobe. We measured local field...
Abstract The hippocampus is an essential hub for episodic memory processing. However, how human hippocampal single neurons code multi-element associations remains unknown. Some argue that each neuron codes invariant element within episode. Instead, others have proposed bind together all elements present in a discrete memory. Here, we provide evidence the latter. We show individual neurons, which term Episode Specific Neurons (ESNs), episodes. These ESNs do not reflect coding of particular...
1. Summary Memory formation and reinstatement are thought to lock the hippocampal theta rhythm, predicting that encoding retrieval processes appear rhythmic themselves. Here, we show rhythmicity can be observed in behavioral responses from memory tasks, where participants indicate, using button presses, timing of or cue-object associative memories. We found no evidence for presses visual tasks same stimuli, questions about already retrieved objects. The oscillations correctly remembered...
Abstract The hippocampus is an essential hub for episodic memory processing. However, how human hippocampal single neurons code multi-element associations remains unknown. Some argue that each neuron codes invariant element within episode. Instead, others have proposed bind together all elements present in a discrete memory. Here, we provide evidence the latter. We show individual neurons, which term Episode Specific Neurons (ESNs), memories using either rate or temporal firing code. find...
Pyramidal cells have two different action potential initiation sites; one at the soma, which receives inputs from synapses contacting basal dendrites or and distal apical dendrite tuft [1]. At latter, calcium spikes can be elicited resulting in a plateau due to influx of that causes pyramidal cell fire bursts potentials [2]. This mechanism used enhance effect top-down synaptic are received on activating its downstream targets. Calcium either by convergence forward-propagating simultaneous...