A5000138494- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Pelvic and Acetabular Injuries
- Scoliosis diagnosis and treatment
- Medical Imaging and Analysis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cervical and Thoracic Myelopathy
- Cancer-related molecular mechanisms research
- Orthopedic Surgery and Rehabilitation
- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Pregnancy-related medical research
- Tendon Structure and Treatment
- Bone and Joint Diseases
- Mesenchymal stem cell research
- Circular RNAs in diseases
- Infectious Diseases and Tuberculosis
- Cancer, Lipids, and Metabolism
- Autophagy in Disease and Therapy
- Pain Management and Placebo Effect
- Spinal Hematomas and Complications
- Plant Toxicity and Pharmacological Properties
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
First Affiliated Hospital of Anhui Medical University
2018-2025
Anhui Medical University
2018-2025
Health First
2018
Spinal cord injury (SCI) can cause irreversible trauma to nervous tissue, leading permanent damage the patient's motor and sensory functions. Extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) simulate most of functions MSCs are considered an ideal treatment option for SCI. However, potential mechanism MSC-EVs SCI still needs be explored. We cultured neurons in vitro investigate effect miR-124 on p62-Keap1-Nrf2 pathway. Besides, containing were injected into a rat spinal...
Intervertebral disc degeneration (IVDD) is the leading cause of low back pain, and repair using nucleus pulposus-derived mesenchymal stem cells (NP-MSCs) represents a promising therapeutic approach. However, both endogenous transplanted NP-MSCs demonstrate limited proliferative capacity, increased apoptosis, reduced resilience to harsh microenvironment within degenerative intervertebral (IVD). RNA sequencing (RNA-seq) was utilized identify genes associated mechanisms that mediate responses...
Hounsfield units (HU), vertebral bone quality (VBQ), and mineral density (BMD) can all serve as predictive indicators for thoracolumbar fragility fractures. This study aims to explore which indicator provides better risk prediction
Traditional trajectory (TT) screws are widely used in lumbar fixation. However, they may require revision surgery some instances, especially patients with osteoporotic spines. Cortical bone (CBT) potentially be to rescue a failed TT screw and vice versa nonosteoporotic This study aimed investigate whether CBT can salvage compromised spines versa.
Loss of nucleus pulposus (NP) cells is as one the primary factors initiating intervertebral disc (IVD) degeneration (IVDD); however, intrinsic physiological mechanisms endogenous NP-derived stem cell (NPSC)-based therapy in IVDD remain poorly understood. Disturbed iron homeostasis commonly observed degenerative diseases, and an acidic microenvironment has been considered a crucial factor IVDD. The molecular mechanism ferroptosis microenvironments during not reported. Herein, we intended to...
The superiorities in proximal facet joint protection of robot-assisted (RA) pedicle screw placement and implantation via the cortical bone trajectory (CBT) have rarely been compared. Moreover, findings on accuracy both techniques are inconsistent. Therefore, we analyzed incidence violation (FJV) RA CBT insertion same study compared them with those conventional (PS) insertion. possible factors affecting FJV were also analyzed.A total 166 patients lumbar degenerative diseases requiring...
Cortical bone trajectory (CBT) has been well-known in spine surgery for obtaining improved fixation while minimizing soft tissue dissection. This study was designed to compare the mineral density (BMD) between CBT and traditional (TT) by using Hounsfield unit (HU) values identify ideal decades of patients suitable lumbar segments this technology from a radiological standpoint.Patients were selected randomly an institutional database based on age (evenly distributed decade life) gender. A...
A retrospective study.To compare the accuracy of pedicle screw placement and proximal facet joint violation (FJV) in single-level degenerative lumbar diseases using cortical bone trajectory (CBT) traditional (TT) techniques, analyze their possible risk factors.CBT screws have been utilized increasingly to improve contact prevent pullout reduce approach-related morbidity. However, studies on intra-pedicular FJV between two methods are rare.A total 40 patients who required instruments were...
Abstract Background Robot-assisted (RA) technique has been increasingly applied in clinical practice, providing promising outcomes of inserting accuracy and cranial facet joint protection. However, studies comparing this novel method with other assisted methods are rare, the controversy superiority between insertion techniques remains. Thus, we compare rates risk factors intrapedicular violation (FJV) RA, fluoroscopy-guided percutaneous (FP), freehand (FH) treatment thoracolumbar fractures....
This is a radiographic and cadaveric study.The aim of this study was to conduct detailed comparison about the parameters between ideal cortical bone trajectory (CBT) practical CBT screw.CBT screws have recently become popular in spinal surgery, mainly because their improved fixation while minimizing soft tissue dissection. However, our knowledge, no previous has provided on screws.The 3-dimensional computed tomography scans 126 vertebrae separated from 40 lumbar spines were studied. After...
Intervertebral disc degeneration (IVDD) is a major cause of morbidity and disability. Our study aimed to investigate the potential cartilage oligomeric matrix protein (COMP) ADAMTS7 (A disintegrin metalloproteinases with thrombospondin motifs 7) as biomarkers for IVDD together their functional relationship. IVD tissues peripheral blood samples were collected from rabbit models over 1-4 weeks. Tissues also clinical patients those stratified into four equal groups according Pfirrmann grading...
OBJECTIVE The aim of this study was to design a novel lumbar cortical bone trajectory (CBT) penetrating the anterior, middle, and posterior vertebral area using imaging; measure relevant parameters find theoretical screw placement possibilities; investigate optimal implantation CBT in patients with osteoporosis. METHODS Three types CBTs appropriate lengths were selected simulate Mimics software. These classified as leading tip pointing quarter (original [CBT-O]) middle (novel A [CBT-A])...