A5024704142- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Radiopharmaceutical Chemistry and Applications
- CAR-T cell therapy research
- GaN-based semiconductor devices and materials
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Metal and Thin Film Mechanics
- Immune cells in cancer
Harbin Medical University
2024-2025
Suzhou Institute of Systems Medicine
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Abstract The therapeutic efficacy of adoptive T cell therapy is largely restricted by reduced viability and dysfunction CD8 + cells. Continuous antigen stimulation disrupts the expansion, effector function, metabolic fitness cells, leading to their differentiation into an exhausted state within tumor microenvironment (TME). While function cycle negative regulator p16 in senescent cells well understood, its role exhaustion remains unclear. In this study, we demonstrated that TCR rapidly...
Abstract In this work, a one-dimensional simulation model is developed to investigate transient high heat flux density thermal management system. A specific capacity at constant pressure equivalent applied simulate the of phase change storage exchanger. Based on experimental results, validated, with which accuracy ranges from 92.3% 98.3%. Then, cooling plate inlet temperature, vapor cycle system and compressor power are numerically analyzed. The comparison without using exchanger also...