A5014616826- Elasticity and Material Modeling
- Aortic Disease and Treatment Approaches
- Coronary Interventions and Diagnostics
- Fluid Dynamics Simulations and Interactions
- Vibration and Dynamic Analysis
- Fluid Dynamics and Vibration Analysis
- Connective tissue disorders research
- Aortic aneurysm repair treatments
- Cellular Mechanics and Interactions
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Function and Risk Factors
- Hydraulic and Pneumatic Systems
- Electrospun Nanofibers in Biomedical Applications
McGill University
2019-2023
Evaluating the nonlinear dynamics of human descending thoracic aortas is essential for building next generation vascular prostheses. This study characterizes dynamics, viscoelastic material properties, and fluid-structure interaction 11 ex-vivo full range physiological heart rates. The aortic segments are harvested from heart-beating donors screened transplants. A mock circulatory loop developed to reproduce pulsatile pressure flow. results show cyclic axisymmetric diameter changes, which...
Experimental data and a suitable material model for human aortas with smooth muscle activation are not available in the literature despite need developing advanced grafts; present study closes this gap. Mechanical characterization of descending thoracic was performed without vascular (VSM) activation. Specimens were taken from 13 heart-beating donors. The aortic segments cooled Belzer UW solution during transport tested within few hours after explantation. VSM achieved through use potassium...
Soft biological tissues are natural biomaterials with structures that have evolved to perform physiological functions, for example, conferring elasticity while preserving the mechanical integrity of arteries. Furthermore, properties tissue extracellular matrix (ECM) significantly affect cell behavior and organ function. ECM strongly affected by collagen ultrastructure, perturbations in networks can cause failure. It is thus crucial understand ultrastructural soft tissues. Herein,...
Abstract For safety reasons, the nuclear fuel assemblies of Pressurized Water Reactors (PWR) must be able to withstand external excitations ranging from large amplitude seismic motions reactor flow-induced vibrations surrounding coolant water. A assembly is composed long slender tubes, most them filled with uranium pellets, maintained in a square array by spacer grids. The grids provide nonlinear flexible boundary condition friction and micro-impacts that complicates dynamics. In order...