A5057121752- HIV Research and Treatment
- Virology and Viral Diseases
- Hepatitis B Virus Studies
- HIV/AIDS Research and Interventions
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Cervical Cancer and HPV Research
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- Parvovirus B19 Infection Studies
- T-cell and Retrovirus Studies
- Blood donation and transfusion practices
- HIV, Drug Use, Sexual Risk
- Immune Cell Function and Interaction
- Syphilis Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Vector-Borne Animal Diseases
- COVID-19 diagnosis using AI
- Viral Infections and Vectors
- Dermatological and COVID-19 studies
University of Ibadan
2014-2024
Federal Medical Centre
2019
University College Hospital, Ibadan
2015-2018
This study investigated measles infection in vaccinated and unvaccinated children presenting with fever maculopapular rash during outbreaks the southern western states of Nigeria. Measles, an acute viral illness caused by a virus family Paramyxoviridae, is vaccine-preventable disease. Measles outbreak common Nigeria, despite national immunization program. Children symptoms general hospitals health centers Nigeria were recruited for this study. Vaccination history, clinical details, 5 mL...
An understanding of the COVID-19 spread is growing around world, yet little known Africa. This paper explores time-space geographies infection focusing on Africa and Nigeria especially. We appraise global-to-local situation confirmed cases, deaths recoveries as well measures engaged in response to pandemic. Findings reveal that South accounts for 40% total cases Africa, followed by Egypt (18%), (6.8%), Ghana (4.6%) Algeria (3.6). Our study shows a significant relationship between population...
Hepatitis B virus (HBV) infection is a major health challenge in sub-Saharan African countries. Chronic HBV risk factor for severe disease progression. Perinatal and sexual transmissions of are the main routes endemic countries like Nigeria. However, there paucity data as regards contributory route transmission to chronic this region. Also, Nigeria, not everyone at high has been identified. Therefore our study investigated prevalence among sexually active individuals Nigeria.Blood samples...
Introduction HIV causes defects in memory B cells children, but the mechanisms of those have not been fully elucidated. One possible mechanism is lack T-cell help to during immune reactions. However, few studies assessed effect on follicular helper T (TFH cells) children. Methods In this study, follicular-homing CD4 and were HIV-infected children compared with from community. CXCR5 CD45RO used as markers cells, respectively. Memory TFH identified CD3+CD8-CD4+CXCR5+CD45RO+PD1+. Central based...
Group A rotavirus (RVA) genotype G12 has spread globally and become one of the most prevalent genotypes in Africa. To understand drivers for its genetic diversity rapid we investigated Bayesian phylogeography, viral evolution population demography Rotavirus We downloaded aligned VP7 gene sequences G12, from thirteen African countries (n = 96). Phylogenetic analysis, Evolutionary analysis Phylogeography was carried out, using MEGA Vs 6, BEAST, SPREAD3. revealed that all fell into lineage III...
Globally, influenza A virus (IAV) and respiratory syncytial (RSV) infection remain very high. There is also a high burden of IAV RSV co-infection in developing countries. To develop universally protective vaccines against these infections, it imperative that viral genes immune correlates pathology are elucidated. As such, we profiled expressions, histopathology immunological responses BALB/c mice infected with and/or this study.RSV A2 A/H3N2/Perth/16/09 (Pr/H3N2) were induced over seven-day...
Rubella is a vaccine-preventable, mild rash-inducing viral disease with complications that include spectrum of birth defects in the developing fetus, especially if infection acquired early months pregnancy. Consequently, primary objective global rubella control programs prevention congenital and associated defects. Despite availability safe effective vaccines, elimination virus many developed countries, substantial commitment to has not been demonstrated countries. This study appraises...
Hepatitis B virus (HBV) infection is a major public health problem for over two billion people infected globally. Occupationally exposed persons are at high risk of HBV and, apart from medical personnel, there dearth information concerning the prevalence and awareness among this population in Nigeria. This study was designed to determine levels hairdressers Ibadan, Hairdressers teachers (unmatched controls) four local government areas Ibadan were tested using ELISA technique. Dried blood...
Abstract Renal dysfunctions are major predictors of co‐morbidities and mortality in HIV‐infected individuals. Unconventional T cells have been shown to regulate kidney functions. However, there is dearth information on the effect HIV‐associated nephropathies γδ DN cells. It also not clear whether cell perturbations observed during early stages HIV infection occur before immune activation. In this study, we investigated relationship between creatinine urea number unconventional individuals at...
The association between household air pollution and lower respiratory tract infections (LRTI) among children under five years of age has been well documented; however, the extent to which microbiome within indoor environment contributes this is uncertain. home assessment (HAIM) study seeks assess abundance microbiota (IM) in homes under-five (U-5Cs) with without LRTI. HAIM a hospital- community-based involving 200 cases controls recruited from three children's hospitals Ibadan, Nigeria....
Abstract Purpose There were approximately 37.9 million persons infected with HIV in 2018 globally, resulting 770,000 deaths annually. Over 50% of this infection and occur sub‐Saharan Africa, countries like Nigeria being seriously affected. has one the highest rates new infections globally. To control Nigeria, there is a need to continually screen high‐risk groups for early subtypes using very sensitive methods. In study, HIV‐1 circulating among febrile blood donors determined. Performance...
Human T-cell lymphotropic virus types I/II (HTLV-I/II) is endemic in some parts of the world including Nigeria. Reported prevalence rates Nigeria have largely focused on blood donors. This study aims at determining HTLV infection among pregnant women Ilorin North-central Serum samples from 276 who were antenatal clinic attendees General and Civil Service Hospitals tested for presence HTLV-I/II antibodies using Enzyme Linked Immunosorbent Assay test kits Diagnostic Automation INC., USA. Out...
Human T Cell Lymphotrophic virus (HTLV) is endemic in many regions of the world including Nigeria but not ubiquitous. It has been shown to be causally associated with cell leukaemia and other myelopathies. Heterosexual contact major route HTLV transmission. STDs patients, pregnant women sexually active individuals have at risk infection. However, there limited information on population mostly countries like Nigeria. Here we determined prevalence I II infection amongst three populations...
The aim of this study was to determine the time interval between human immunodeficiency virus (HIV) infection and first diagnosis among drug-naïve individuals in Badagry, Nigeria.A sample 213 subjects who tested HIV positive for were enrolled study. performed using Startpak® Determine® kits, a CD4 count carried out FACS Count® flow cytometer. mean values determined by gender age groups. initial testing calculated based on average decay rate per calendar year, data analysis SPSS software.At...
Introduction. Hepatitis B virus (HBV) infection is the leading cause of hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). HBV genotype E (HBV/E) predominant in West Africa has been linked epidemiologically with chronic occult infections as well development HCC. Mutations surface polymerase genes have associated infection, drug resistance, vaccine escape, Hypothesis/Gap Statement. There limited data on occurrence patterns mutations escape HCC for HBV/E. Aim. This study...
ABSTRACT The ongoing SARSCoV-2 pandemic was introduced into Africa on 14 th February 2020 and has rapidly spread across the continent causing severe public health crisis mortality. We investigated genetic diversity evolution of this virus during early outbreak months using whole genome sequences. performed; recombination analysis against closely related CoV, Bayesian time scaled phylogeny spike protein amino acid mutations. Results from our showed signals between AfrSARSCoV-2 sequences...
In 2019, 38 million people lived with HIV-1 infection resulting in 690,000 deaths. Over 50% of this and its associated deaths occurred Sub-Saharan Africa. The West African region is a known hotspot the epidemic. There need to develop an vaccine if HIV epidemic would be effectively controlled. Few protective cytotoxic T Lymphocytes (CTL) epitopes within GAG (HIV_gagconsv) have been previously identified functionally conserved among M group. These are currently focus universal cell-based...
Human immunodeficiency virus (HIV) infection leads to progressive loss of CD4 T cells. Antiretroviral therapy has been able inhibit this process, resulting in significant level immune recovery and function. Our aim is investigate the dynamics among HIV patients Lagos, Nigeria. A total 213 HIV-positive individuals were enrolled between October 2007 May 2008, followed up for 9 months based on count. analysis was done by flow cytometry at enrollment after every 3 months. Data grouped according...
The COVID-19 pandemic challenged health systems globally. Reverse transcription polymerase chain reaction (RT-PCR) is the gold standard for detecting presence of SARS-CoV-2 in clinical samples. Rapid diagnostic test (RDT) kits have been widely used Nigeria. This has greatly improved turnover rates and significantly decreased high technical demands RT-PCR. However, there currently no nationally representative evaluation performance characteristics reliability these kits. study assessed...