A5102915166- Rheumatoid Arthritis Research and Therapies
- Musculoskeletal synovial abnormalities and treatments
- Urinary Bladder and Prostate Research
- Monoclonal and Polyclonal Antibodies Research
- Cutaneous lymphoproliferative disorders research
- Osteoarthritis Treatment and Mechanisms
- Lymphoma Diagnosis and Treatment
- Hormonal and reproductive studies
- Sexual function and dysfunction studies
William Harvey Research Institute
2018-2023
Queen Mary University of London
2022-2023
Armed Forces Institute of Pathology
1993
Patients with rheumatoid arthritis (RA) receive highly targeted biologic therapies without previous knowledge of target expression levels in the diseased tissue. Approximately 40% patients do not respond to individual and 5–20% are refractory all. In a biopsy-based, precision-medicine, randomized clinical trial RA (R4RA; n = 164), low/absent synovial B cell molecular signature had lower response rituximab (anti-CD20 monoclonal antibody) compared that tocilizumab (anti-IL6R although exact...
To evaluate whether the choice of synovial biopsy technique (arthroscopy, blind needle [BN] biopsy, ultrasound [US]-guided portal and forceps [P&F], or US-guided [NB]) translates to significant variation in tissue quality quantity, with aim informing recommendations for sampling within clinical trials.In total, 159 procedures from 5 academic rheumatology centers were evaluated. Hematoxylin eosin-stained, paraffin-embedded sections patients inflammatory arthritis assessed order determine...
Osteoarthritis (OA) is a debilitating and heterogeneous condition, characterized by various levels of articular cartilage degradation, osteophytes formation, synovial inflammation. Multiple evidences suggest that synovitis may appear early in the disease development correlates with severity pain, therefore representing relevant therapeutic target. In typical synovitis-driven joint disease, namely rheumatoid arthritis (RA), several pathotypes have been described our group associated clinical...
Dynamic penile scintigraphy was performed using 99Tcm-labelled autologous erythrocytes in five normally potent volunteers and 22 patients with erectile dysfunction including 11 psychogenic vasculogenic impotence (four arteriogenic, three venogenic, arteriogenic one neurogenic). Penile radioactivity changes the flaccid state were monitored by a gamma camera for 60 min after injection of radionuclide. The time-activity curves normal controls characteristically showed secondary pulses increased...