A5041919965- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Crystallization and Solubility Studies
- Analytical Methods in Pharmaceuticals
- Advancements in Transdermal Drug Delivery
- Cancer, Lipids, and Metabolism
- Drug Transport and Resistance Mechanisms
- RNA Interference and Gene Delivery
- Protein purification and stability
- Natural Compound Pharmacology Studies
- 3D Printing in Biomedical Research
- Microfluidic and Bio-sensing Technologies
- Forensic Toxicology and Drug Analysis
- Cannabis and Cannabinoid Research
- Monoclonal and Polyclonal Antibodies Research
- Electrohydrodynamics and Fluid Dynamics
- Traditional Chinese Medicine Studies
- Traditional Chinese Medicine Analysis
- Opioid Use Disorder Treatment
- Analytical Chemistry and Chromatography
- Hydrogels: synthesis, properties, applications
- Immunotherapy and Immune Responses
- Surfactants and Colloidal Systems
- Nanoplatforms for cancer theranostics
Jeju National University
2022-2025
Ajou University
2013-2024
Il-Yang Pharmaceutical (South Korea)
2024
University of Alberta
2020-2022
Korea Institute of Machinery and Materials
2014
Background/Objectives: Influenza vaccines require good thermal stability without the need for refrigerator storage. Although fatty acid-conjugated hemagglutinin (Heg) vaccine antigen provides in both solid and liquid states, its therapeutic effectiveness must be validated vivo. This study aimed to investigate immunogenicity of thermally stabilized Heg-oleic acid conjugate (HOC) compare it with native Heg as a reference. Method: To evaluate HOC immunogenicity, an enzyme-linked immunosorbent...
The objective of this study was to design and evaluate an orodispersible film (ODF) composed aripiprazole (ARP), prepared using a conventional solvent casting technique, fuse three-dimensional (3D) printing technique with hot-melt extrusion (HME) filament. Klucel® LF (hydroxypropyl cellulose, HPC) PE-05JPS® (polyvinyl alcohol, PVA) were used as backbone polymers for 3D casting. HPC-, PVA-, ARP-loaded filaments applied HME. physicochemical mechanical properties the films optimized based on...
Leuprolide (LEU), a synthetic nonapeptide analog of naturally occurring gonadotropin-releasing hormone (GnRH), could exert direct inhibitory activity on the proliferation prostate cancer cells. However, short half-life in blood and biopharmaceutical problem LEU limit this anticancer activity.To improve its druggability for improving activity, amine-group targeted was conjugated with different chain lengths saturated fatty acids (FAs).LEU-fatty acid conjugates (LFCs) were synthesized by...
This study aimed to investigate the role of micellization sodium lauryl sulfate (SLS) in poloxamer 407 (POX)-based solid dispersions (POX-based SDs) using anti-solvent method enhancing dissolution rate practically water-insoluble cilostazol (CLT). Herein, SLS was incorporated into CLT-loaded SDs, at a weight ratio 50:50:10 CLT, POX, and by three different methods: anti-solvent, fusion (60 °C), solvent (ethanol) evaporation. The SDs containing micellar were superior transformation crystalline...
This study was tasked with the design of mucoadhesive buccal films (MBFs) containing a peptide drug, leuprolide (LEU), or its diverse nanoparticles (NPs), for enhanced membrane permeability via self-assembled nanonization and deformable behavior. An LEU-oleic acid conjugate (LOC) NPs (LON) were developed. Additionally, variant LON (d-LON) originally developed by incorporating l-α-phosphatidylcholine into as an edge activator. The physicochemical properties d-LON, encompassing particle size,...
This study aimed to investigate the enhancement of cannabinoid acid solubility and stability through formation a acid/cyclodextrin (CD) inclusion complex. Two acids, tetrahydro-cannabinolic (THCA) cannabidiolic (CBDA), were selected as model drug along with five types CD: α-cyclodextrin (α-CD), β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD), hydroxypropyl-β-cyclodextrin (HP-β-CD), methylated-β-cyclodextrin (M-β-CD). Phase studies conducted using various CD determine complex stoichiometry. The...
The crystal changes and salt formation of poorly water-soluble telmisartan (TEL) in various solvents were investigated for enhanced solubility, stability crystallinity. Polymorphic behaviors TEL characterized by dispersing distilled water, acetone, acetonitrile, DMSO, or ethanol using Method I: without heat then dried under vacuum at room temperature; II: with below boiling temperature, cooled 5 °C, 40 °C. For (Method III), the following four powdered mixtures prepared solution hydrochloric...