A5033954131- Oral microbiology and periodontitis research
- Genomic variations and chromosomal abnormalities
- Dental Implant Techniques and Outcomes
- Neurogenetic and Muscular Disorders Research
- Dental materials and restorations
- Genetic Syndromes and Imprinting
- Inflammatory mediators and NSAID effects
- Dental Radiography and Imaging
- Viral-associated cancers and disorders
- Chromatin Remodeling and Cancer
- Periodontal Regeneration and Treatments
- Bee Products Chemical Analysis
- Bone and Dental Protein Studies
- NF-κB Signaling Pathways
- Myxozoan Parasites in Aquatic Species
- Endodontics and Root Canal Treatments
- Bone Metabolism and Diseases
- Medical and Biological Ozone Research
- Dental Erosion and Treatment
- Reproductive System and Pregnancy
- Salivary Gland Disorders and Functions
- Genomics and Rare Diseases
- Maternal and Neonatal Healthcare
- Intensive Care Unit Cognitive Disorders
- Treatment of Major Depression
Pontifícia Universidade Católica de Goiás
2025
Universidade Federal do Rio Grande do Norte
2022-2024
Universidade de São Paulo
2011-2021
Seevic College
2021
Universidade de Ribeirão Preto
2017-2021
Universidade Estadual Paulista (Unesp)
2011-2015
Greenwood Genetic Center
2011
Diabetes mellitus increases periodontitis and pathogenicity of the oral microbiome. To further understand mechanisms through which diabetes affects periodontitis, we examined its impact on periodontal ligament fibroblasts in vivo vitro. Periodontitis was induced by inoculation Porphyromonas gingivalis Fusobacterium nucleatum normoglycemic diabetic mice. Diabetes, multiple low-dose injections streptozotocin increased osteoclast numbers recruitment neutrophils to ligament, could be accounted...
Periodontal pathogenesis takes into consideration that disease results from a complex inflammatory immune response. Among the major cytokines related to periodontal damage, interleukin (IL)-6 enhances cascade of tissue destruction. Tocilizumab (TCZ) is humanized monoclonal anti-human IL-6 receptor inhibits IL-6-mediated proinflammatory activity. This study aimed elucidate whether TCZ deleterious effect ligature-induced periodontitis.Experimental periodontitis was treated with systemic...
Considering the lack of consensus related to impact selective IL-6 receptor inhibition on bone remodeling and scarcity reports, especially large defects, this study proposed evaluate biological inhibitor interleukin-6 (tocilizumab) in an experimental model critical calvarial defect rats. In preclinical vivo study, 24 male Wistar rats were randomly divided into two groups (n=12/group): treated with collagen sponge (CG) associated 2 mg/kg tocilizumab (TCZ). The parietal was created using 8-mm...
Background and Objective The potential benefits of statins in modulating periodontal disease is supported by vitro clinical studies showing can induce a lower expression proinflammatory cytokines matrix metalloproteinases. aim this study was to evaluate the effects rosuvastatin ( ST ) on ligature‐induced periodontitis spontaneously hypertensive rats SHR ). Material Methods Fifty‐four adult male were divided into three groups: ‐C, ‐L ‐L‐ (C, control; L, ligature groups). In group , animals...
PURPOSE To compare the effect of toothbrushing abrasion with hydrated silica-based whitening and regular toothpastes on root dentin using contact profilometry. MATERIALS AND METHODS Ninety specimens (4 x 4 2 mm) were randomly divided into five experimental groups (n = 18) according to toothpaste: three (W1, W2 W3) two (R1 R2) produced by different manufacturers. Using a brushing machine, each specimen was brushed constant load 300 g for 2500 cycles (4.5 cycles/s). The diluted at ratio 1:3...
ABSTRACT Objectives To evaluate the antimicrobial activity, mechanical properties, and fluoride release capacity of glass ionomer cement (GIC) used for cementing orthodontic bands modified by ethanolic extract red propolis (EERP) in different concentrations. Materials Methods Two GICs containing EERP at 10%, 25%, 50%, were used. The following assays carried out: cell viability tests against Streptococcus mutans Candida albicans, diametral tensile strength, compressive shear bond...
PURPOSE To evaluate the biocompatibility in rat subcutaneous tissue of conventional orthodontic cements, Riva (R) and Meron (M), modified by addition ethanolic extract red propolis (EERP), at different concentrations time intervals. MATERIALS AND METHODS One hundred eight male adult Wistar rats were used, distributed nine groups cements with added EERP used (C-control, MC, M10, M25, M50, RC, R10, R25, R50). The sacrificed after 3 intervals (7, 15, 30 days). Histological immunohistochemical...
Objective: The aim of this study was to analyze by clinical and radiographic parameters the use enamel matrix derivative (EMD) with or without a synthetic bone substitute (Bone Ceramic) in treatment periodontal intrabony defects humans. Methods: Nine patients eighteen need for were selected assigned EMD plus Bone Ceramic assessing measurements. Results: At one year, mean probing depth (PD) reduction demonstrated improvements all groups when compared baseline (P<0.01). 1 year PD ≥ 2mm...
Sotos syndrome (SoS) is a multiple anomaly, congenital disorder characterized by overgrowth, macrocephaly, distinctive facial features and variable degree of intellectual disability. Haploinsufficiency the <i>NSD1</i> gene at 5q35.3, arising from 5q35 microdeletions, point mutations, partial deletions, accounts for majority patients with SoS. Recently, mutations possible pathogenetic rare CNVs, both affecting few candidate genes have been reported in Sotos-like overgrowth...
TEMA: o objetivo deste estudo foi descrever os aspectos clínico, comportamental, cognitivo e comunicativo de indivíduos com diagnóstico genético da Síndrome Smith-Magenis. PROCEDIMENTOS: participaram dois do sexo masculino, nove 19 anos. Realizou-se a avaliação genética clínica laboratorial (teste FISH, utilizando sonda para região 17p11.2). A psicológica constou observação comportamental aplicação Escala Wechsler Inteligência. Fonoaudiológica realizada por meio procedimentos formais...
Gingival pigmentation is a discoloration of the gingiva due to variety lesions and conditions associated with several endogenous exogenous etiologic features.The purpose this study describe report gingival in patient who used doxycycline.A 21-year-old Caucasian female was under dermatological treatment antibiotic therapy doxycycline 100 mg (one time day) for 90 days. She presented brown at margin on facial surfaces upper lower anterior incisors premolars. The evaluated by immunohistochemical...