A5017418327- HIV/AIDS Impact and Responses
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Pharmacological Receptor Mechanisms and Effects
- Neuropeptides and Animal Physiology
- Poverty, Education, and Child Welfare
- Adolescent Sexual and Reproductive Health
- Neuroendocrine regulation and behavior
- COVID-19 Clinical Research Studies
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Advanced Semiconductor Detectors and Materials
- Yersinia bacterium, plague, ectoparasites research
- Regulation of Appetite and Obesity
- Epilepsy research and treatment
- HIV/AIDS Research and Interventions
- SARS-CoV-2 and COVID-19 Research
- Rabies epidemiology and control
- Pain Mechanisms and Treatments
- Pharmacology and Obesity Treatment
- Pneumonia and Respiratory Infections
- Advanced X-ray and CT Imaging
- Effects and risks of endocrine disrupting chemicals
NIHR Clinical Research Network
2021
National Institute for Health Research
2021
National Records of Scotland
2021
Intensive Care National Audit & Research Centre
2021
Public Health Scotland
2021
University Hospitals Birmingham NHS Foundation Trust
2021
Public Health England
2021
Oxford University Clinical Research Unit
2021
Eijkman Institute for Molecular Biology
2021
Oxford University Clinical Research Unit Indonesia
2021
Abstract An orphan enumeration survey was conducted in 570 households and around Mutare, Zimbabwe 1992; 18.3% (95% CI 15.1-21.5%) of included orphans. 12.8% 11.2-14.3%) children under 15 years old had a father or mother who died; 5% orphans lost both parents. Orphan prevalence highest peri-urban rural area (17.2%) lowest middle income medium density urban suburb (4.3%). Recent increases parental deaths were noted; 50% since 1987 could be ascribed to AIDS. household heads likely older less...
1. Sibutramine is a novel 5-hydroxytryptamine (5-HT) and noradrenaline reuptake inhibitor (serotonin-noradrenaline inhibitor, SNRI) which currently being developed as treatment for obesity. has been shown to decrease food intake in the rat. In this study we have used variety of monoamine receptor antagonists examine pharmacological mechanisms underlying sibutramine-induced hypophagia. 2. Individually-housed male Sprague-Dawley rats were maintained on reversed phase lighting with free access...
After a single dose of ethane dimethanesulphonate (EDS) (75 mg/kg) to rats the prolonged antispermatogenic action is due temporary elimination functional Leydig cell population. Replacement therapy with testosterone propionate (3 mg/day) maintains spermatogenic epithelium but EDS effect develops when hormone treatment discontinued. In contrast, short hCG (10-100 i.u./day) or LH (714 micrograms/day), starting before dose, permanently protects epithelium. FSH was completely ineffective....
The effects of the potent 5‐hydroxytryptamine (5‐HT) and noradrenaline reuptake inhibitor (serotonin‐noradrenaline inhibitor, SNRI), sibutramine, on cumulative food intake freely‐feeding male Sprague‐Dawley rats during an 8 h dark period were investigated compared to those selective 5‐HT (selective serotonin SSRI), fluoxetine; nisoxetine; inhibitors, venlafaxine duloxetine; releaser (+)‐fenfluramine. Sibutramine (3 10 mg kg −1 , p.o.) (+)‐fenfluramine (1 3 produced a significant,...
Te inclusions existing at high concentrations in CdZnTe (CZT) material can degrade the performance of CZT detectors. These microscopic defects trap free electrons generated by incident radiation, so entailing significant fluctuations total collected charge and thereby strongly affecting energy resolution thick (long-drift) Such effects were demonstrated thin planar detectors, and, many cases, they proved to be dominant cause low wherein losses accumulate along charge's drift path. We...
Summary. Young male rats were exposed to Busulphan on selected days between the 5th day of foetal life and Day 15 post partum, inclusive. The drug apparently had no effect sex cells when administered pregnant female Days 5 7 coitum. Later in pregnancy a destructive action became rapidly more powerful. developing foetus destroyed after exposure from 13 coitum onwards. Supporting cells, which proliferate simultaneously with appeared be quite indifferent this treatment Busulphan. Treatment...
Summary. Female rats were exposed to Busulphan on selected days between the 5th day of foetal life and Day 15 post partum, inclusive. The drug apparently had no effect sex cells when administered pregnant female Days 5 7 coitum. Later in pregnancy a destructive action became rapidly more powerful. So far as developing ovary is concerned it would seem that at this dose level, i.e. 10 mg/kg intraperitoneally, confined precursor oocyte, namely oogonium these enter meiotic prophase about 17th...
Oseltamivir is the prodrug of Ro64-0802 (GS4071), a potent and selective inhibitor influenza A B virus neuraminidases. Three randomized, double-blind, placebo-controlled, parallel-group studies evaluated oral oseltamivir for early treatment (75 or 150 mg twice daily 5 days) prevention once 7 experimental infection in healthy susceptible adults. Treatment study (n=60) demonstrated similar trends to (n=117), which 75 doses introduced 24 h after inoculation reduced median area under curve (AUC)...
Summary. Histological changes in the rat testis were correlated with antifertility effects of injections three diol diesters methanesulphonic acid. The compounds are consecutive members a homologous series each differing by -CH2- from its neighbours. diester ethylene glycol (EDS) caused antispermatogenic resembling those following hypophysectomy and was associated involution prostate epididymis; spermatocoele formation occurred latter organ. Methylene dimethanesulphonate 1,3-propylene...
This study intervenes in the presumed remoteness of visual condition and experience aerial image created by drone apparatus, to create new knowledge about cultural societal spaces that these envisioning technologies reveal. Using The Walls Surround Us, a short drone-film Peace Belfast local film-maker James Brennan, this captures participant’s lived place is film’s subject, analyses how system signification captured within film, operates intervene, sustain, or subvert his association with...
From a study on the cost and quality of community home-based care (CHBC) for HIV/AIDS patients in Zimbabwe, programme household costs were estimated. Interviews, using structured questionnaire, held with 60 caregivers sampled from six types established CHBC schemes. Detailed information was collected four home programmes, two urban rural. The visit programmes studied estimated to be Z$129 (US$16) one, Z$183 (US$23) other. In one rural schemes, Z$313 (US$38), other this Z$343 (US$42). A large...
The in vivo anticonvulsant effects and vitro metabotropic glutamate receptor selectivity of (S)-4-carboxy-3-hydroxy-phenylglycine [(S)-4C3HPG] were examined. Intracerebroventricular injection (S)-4C3HPG dose-dependently antagonized audiogenic-induced clonic tonic convulsions DBA/2 mice with ED50 values 76 110-nmol per mouse, respectively. inhibited the spontaneously evoked epileptic spikes a cingulate cortex-corpus callosum slice preparation. displaced binding [3H]glutamate membranes...