A5101459954- Advanced Neuroimaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Glioma Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Advanced MRI Techniques and Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Neonatal Respiratory Health Research
- Neuroblastoma Research and Treatments
- Head and Neck Surgical Oncology
- Infectious Diseases and Tuberculosis
- Hematological disorders and diagnostics
- Educational Methods and Analysis
- Hedgehog Signaling Pathway Studies
- Education Practices and Challenges
- Fetal and Pediatric Neurological Disorders
- Ocular Oncology and Treatments
- Neurosurgical Procedures and Complications
- Neonatal and fetal brain pathology
- Congenital Anomalies and Fetal Surgery
- RNA modifications and cancer
- Parathyroid Disorders and Treatments
- Osteomyelitis and Bone Disorders Research
- Historical and Religious Studies of Rome
Children's Hospital Research Institute of Manitoba
2024
University of Manitoba
2003-2024
University of California Davis Medical Center
2018-2024
University of California, Davis
2017-2024
Research Institute of Radiology
2023
UC Davis Health System
2022
UC Davis Comprehensive Cancer Center
2017
Research Institute in Oncology and Hematology
2017
CancerCare Manitoba
2017
Johns Hopkins University
2009-2012
Inflammatory demyelination and axon damage in the corpus callosum are prominent features of multiple sclerosis (MS) may partially account for impaired performance on complex tasks. The objective this article was to characterize quantitative callosal MRI abnormalities their association with disability. In 69 participants MS 29 healthy volunteers, lesional extralesional indices were estimated via diffusion tensor tractography. expanded disability status scale (EDSS) functional composite (MSFC)...
<h3>Objective</h3> To determine whether damage to the optic radiation (OR) in multiple sclerosis (MS) is associated with nerve injury and visual dysfunction. <h3>Design</h3> Case-control study. <h3>Setting</h3> Referral center. <h3>Participants</h3> Ninety referred patients MS 29 healthy volunteers. <h3>Main Outcome Measures</h3> Magnetic resonance imaging indices along OR were reconstructed diffusion tensor tractography. Retinal fiber layer thickness acuity at high low contrast measured a...
ABSTRACT BACKGROUND AND PURPOSE Visual disability is common in multiple sclerosis, but its relationship to abnormalities of the optic tracts remains unknown. Because they are only rarely affected by lesions, may represent a good model for assessing imaging properties normal-appearing white matter sclerosis. METHODS Whole-brain diffusion tensor was performed on 34 individuals with sclerosis and 26 healthy volunteers. The were reconstructed tractography, tract-specific indices quantified. In...
Abstract miR-200b plays a role in epithelial-to-mesenchymal transition (EMT) cancer. We recently reported abnormal expression of the context human pulmonary hypoplasia congenital diaphragmatic hernia (CDH). Smaller lung size, lower number airway generations, and thicker mesenchyme characterize CDH. The aim this study was to define during development. Here we show that −/− mice have function due dysfunctional surfactant, increased fibroblast-like cells between alveolar walls. profiled...
Altered amygdala development is implicated in the neurobiology of autism, but little known about coordinated brain regions directly connected with amygdala. Here we investigated volumetric an amygdala-connected network, defined as set monosynaptic connections amygdala, autism from early to middle childhood. A total 950 longitudinal structural MRI scans were acquired 282 children (93 female) and 128 typical (61 at up four time points (mean ages: 39, 52, 64, 137 months, respectively). Volumes...
Diffusion tensor imaging (DTI) has become a valuable tool in both the research and clinical evaluation of subjects. We sought to quantify interobserver intraobserver variability diffusivity diffusion anisotropy measurements with regard specific regions interest (ROIs).The subject group consisted 5 healthy control subjects 7 study (all males; 16-19 years old; mean age = 17.5 years), as part protocol for closed head injury. Two whole-brain DTI scans were acquired on 3T scanner each subject....
BACKGROUND Abusive head trauma (AHT) peaks during early infancy and decreases in toddler years. Infants toddlers experience different injuries, possibly impacting the risk of mortality. We aimed to evaluate association age with METHODS conducted a retrospective study AHT hospitalizations 2000, 2003, 2006, 2009, 2012 from Kid's Inpatient Claims Database. An accidental cohort was included hypothesize that between mortality is unique abuse. A nested multivariable logistic regression used...
Background:The use of Thymoglobulin induction therapy in living-donor renal transplantation remains controversial. We aimed to evaluate outcomes living-related donor (LRD) and living unrelated (LURD) transplants with induction.Material/Methods:We retrospectively analysed the outcome all induced performed at our centre from 2002 2010.Results:We reviewed 100 (LRD=60; LURD=40) who received thymoglobulin (single dose, 1.5 mg/kg bodyweight) a mean follow-up 52.6±31.9 months. Although baseline...
Recent studies provide compelling evidence to suggest that the tight junction protein claudin 1, aberrantly expressed in several cancer types, plays an important role progression. Dysregulation of 1 has been shown induce epithelial mesenchymal transition (EMT). Furthermore, activation ERK signaling pathway by kinase C (PKC) was be necessary for EMT induction. Whether PKC is involved regulating breast progression not addressed. The activator 12-O-tetradecanoylphorbol 13-acetate (TPA) used...
<b>BACKGROUND AND PURPOSE:</b> Neuroimaging methods have been used to improve our understanding of the topographic organization brain. In study, proton <sup>1</sup>H-MR spectroscopic imaging was evaluate frontal lobe function. The goal determine relationship between neuropsychological measures function and levels a surrogate neuronal marker, <i>N</i>-acetylaspartate (NAA), in typically developing healthy children adolescents. <b>MATERIALS METHODS:</b> Fifty-one (25 girls; 6.2–18.3 years age;...
<h3>BACKGROUND AND PURPOSE:</h3> Type 1 diabetes affects over 200,000 children in the United States and is associated with an increased risk of cognitive dysfunction. Prior single-site, single-voxel MRS case reports studies have identified associations between reduced NAA/Cr, a marker neuroaxonal loss, type diabetes. However, NAA/Cr differences among various disease complications or across different brain tissues remain unclear. To better understand this phenomenon role characterizing it, we...
We report magnetic resonance (MR) findings in a patient with histologically proven lymphangiomatosis history of chylothorax, diffuse lung infiltrates, spinal involvement, cystic lesions the mediastinum, and mesentery thickening. The also had infiltration right brachial plexus, similar imaging as lesions. Although osseous extraosseous involvement may be seen frequently lymphangiomatosis, plexus has not been previously reported.
Intracranial tumors are the most common neoplasms of childhood, accounting for approximately 20% all pediatric malignancies. Radiation therapy has led directly to significant increases in survival children with certain types intracranial tumors; however, given aggressive nature this therapy, at risk exhibiting changes brain structure, neuronal biochemistry, and neurocognitive functioning. In case report, we present neuropsychological, magnetic resonance imaging, proton spectroscopic...