Le Chen

ORCID: 0000-0003-4963-025X
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Research Areas
  • Mitochondrial Function and Pathology
  • Glycogen Storage Diseases and Myoclonus
  • Adipose Tissue and Metabolism
  • Bat Biology and Ecology Studies
  • Diet and metabolism studies
  • Pancreatic function and diabetes
  • Effects of Environmental Stressors on Livestock
  • Spaceflight effects on biology
  • Cytomegalovirus and herpesvirus research
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Adenosine and Purinergic Signaling
  • Calcium signaling and nucleotide metabolism

Qufu Normal University
2023-2025

Wuhan University
2025

Abstract Background Breast cancer has become a severe threat to human health, making it imperative identify effective drugs and therapeutic targets. Methods Various molecular biology experiments, such as western blot analysis, cytologic effect, co‐immunoprecipitation, immunofluorescence assays, well nude mouse xenograft tumor model, were used comprehensively analyze the impact of gamma‐interferon‐inducible lysosomal thiol reductase (GILT) on malignant phenotype breast cells. This work was...

10.1002/cai2.161 article EN cc-by-nc-nd Cancer Innovation 2025-03-15

ABSTRACT Objectives: The effects of weightlessness on the liver were studied using a tail suspension (TS) male mouse model. Methods: 0-, 2- and 4-week TS (CON, TS2 TS4 groups) glycogen lipid content, as well molecular processes synthesis degradation pathways, examined. Results: (1) number glycogenosomes under ultrastructure content considerably larger in group than other two groups. (2) In group, synthase activity remained constant while phosphorylase dropped, indicating that breakdown was...

10.1590/1517-8692202329022022_0115i article EN Revista Brasileira de Medicina do Esporte 2023-01-01

RESUMO Objetivos: Os efeitos da antigravidade no fígado foram estudados usando um modelo de camundongo macho com a suspensão pela cauda (TS, tail suspension). Métodos: Foram examinados os TS em 0, 2 e 4 semanas (grupos CON, TS2 TS4) sobre o conteúdo glicogênio lipídios, bem como nos processos moleculares das vias síntese degradação. Resultados: (1) O número glicogenossomos ultraestruturais teor expressivamente maiores grupo TS4 do que outros dois grupos. (2) No TS4, atividade sintase...

10.1590/1517-8692202329022022_0115p article PT Revista Brasileira de Medicina do Esporte 2023-01-01
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