A5049723223- Medicinal Plants and Bioactive Compounds
- Phytochemical and Pharmacological Studies
- Drug-Induced Hepatotoxicity and Protection
- Hydrogen's biological and therapeutic effects
- Neurological Disease Mechanisms and Treatments
- Liver Disease and Transplantation
- Genomics, phytochemicals, and oxidative stress
- Cancer Research and Treatments
- Effects of Radiation Exposure
- Food Quality and Safety Studies
- Radiation Therapy and Dosimetry
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Cell death mechanisms and regulation
- Liver physiology and pathology
- Cannabis and Cannabinoid Research
- Immune Response and Inflammation
- Seaweed-derived Bioactive Compounds
- Virus-based gene therapy research
- interferon and immune responses
- CAR-T cell therapy research
- Antifungal resistance and susceptibility
- Pharmacological Effects and Toxicity Studies
- Bacteriophages and microbial interactions
University of Kansas Medical Center
2019-2025
University of Kansas
2023
Universidad de Santiago de Chile
2019-2021
Abstract Purpose: The radiosensitivity of the normal intestinal epithelium is major limiting factor for definitive radiotherapy against abdominal malignancies. Radiosensitizers, which can be used without augmenting radiation toxicity to tissue, are still an unmet need. Inhibition proteosomal degradation being developed as a therapeutic strategy anticancer therapy cancer cells more susceptible proteasomal inhibition–induced cytotoxicity compared with cells. Auranofin, gold-containing...
Abstract An overdose of acetaminophen (APAP) is the leading cause drug-induced hepatotoxicity and acute liver failure (ALF) in United States. It established that predominant mode hepatocyte cell death after an APAP through necrosis, it now recognized this occurs regulated pathways involving RIP kinases. These kinases, along with pseudo-kinase MLKL are central players classical necroptotic death. Despite skepticism regarding role necroptosis APAP-induced injury, recent research demonstrating...
Oncolytic virus therapy has been tested against cancer in preclinical models and clinical assays. Current evidence shows that viruses induce cytopathic effects associated with fusogenic protein-mediated syncytium formation immunogenic cell death of eukaryotic cells. We have previously demonstrated tumor bodies generated from cells expressing the protein infectious salmon anemia (ISAV-F) enhance crosspriming display prophylactic antitumor activity melanoma tumors. In this work, we evaluated...
Abstract Acetaminophen (APAP) overdose is the main cause of acute liver failure in Western countries. The mechanism APAP hepatotoxicity associated with centrilobular necrosis which initiates infiltration neutrophils, monocytes, and other leukocytes to area necrosis. Although it has been recognized that this immune cells plays a critical role promoting repair, cell clearance important for resolution inflammation return normal homeostasis are not well characterized. CXCR4 chemokine receptor...
<b>Abstract ID 29424</b> <b>Poster Board 226</b> <b>Background:</b> Acute liver failure (ALF) is characterized by hepatic encephalopathy, coagulopathy, peripheral vasodilation and organ failure. The majority of all ALF cases in the United States UK are due to acetaminophen (APAP) overdose. An extensive body work has elucidated molecular mechanisms hepatocyte necrosis during APAP overdose, but detailed involved development have been largely unexplored. Previous demonstrated that a severe...
Melanoma immunotherapy, specifically the autotransplant of dendritic cells charged with tumors antigens, has shown promising results in clinical trials. The positive effects this therapy have been associated to increased Th17 response and delayed-type hypersensitivity (DTH) against tumor antigens. Some synthetic compounds, such as diphenylcyclopropenone (DPCP), are capable triggering a DTH cutaneous malignancies also induce clinically relevant melanoma. In work, we evaluated Litre extract...
Acute hepatic failure is associated with high morbidity and mortality for which the only definitive therapy liver transplantation. Some fraction of those who undergo emergency transplantation have been shown to recover native function when transplanted an auxiliary graft that leaves part intact. Thus, could averted development use some form support. The costs developing testing support systems be dramatically reduced by availability a reliable large animal model therapeutic window allows...
Active immunotherapy against cancer is based on immune system stimulation, triggering efficient and long-lasting antigen-specific responses. Immunization strategies using whole dead cells from tumor tissue, containing specific antigens inside, have become a promising approach, providing lymphocyte activation through dendritic (DCs). In this work, we generate CT26, E.G7, EL4 live as antigen sources, which termed immunogenic cell bodies (ICBs), generated by simple cost-efficient...
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<p>mRNA expression of UPR downstream proapoptotic molecule</p>
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<div>AbstractPurpose:<p>The radiosensitivity of the normal intestinal epithelium is major limiting factor for definitive radiotherapy against abdominal malignancies. Radiosensitizers, which can be used without augmenting radiation toxicity to tissue, are still an unmet need. Inhibition proteosomal degradation being developed as a therapeutic strategy anticancer therapy cancer cells more susceptible proteasomal inhibition–induced cytotoxicity compared with cells. Auranofin,...
<div>AbstractPurpose:<p>The radiosensitivity of the normal intestinal epithelium is major limiting factor for definitive radiotherapy against abdominal malignancies. Radiosensitizers, which can be used without augmenting radiation toxicity to tissue, are still an unmet need. Inhibition proteosomal degradation being developed as a therapeutic strategy anticancer therapy cancer cells more susceptible proteasomal inhibition–induced cytotoxicity compared with cells. Auranofin,...
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