A5100349663- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Endoplasmic Reticulum Stress and Disease
- Machine Learning in Bioinformatics
- Oral microbiology and periodontitis research
- RNA modifications and cancer
- Microbial Metabolism and Applications
- Streptococcal Infections and Treatments
- Adenosine and Purinergic Signaling
- Cancer Genomics and Diagnostics
- Plant-Microbe Interactions and Immunity
- Lipid metabolism and biosynthesis
- Plant Pathogens and Fungal Diseases
- Endometrial and Cervical Cancer Treatments
- SARS-CoV-2 and COVID-19 Research
- Bone Tumor Diagnosis and Treatments
- interferon and immune responses
- Neurogenesis and neuroplasticity mechanisms
- Adipose Tissue and Metabolism
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Genomics and Chromatin Dynamics
Harbin Medical University
2024
Xijing Hospital
2024
Air Force Medical University
2024
Southeast University
2023
Zhongda Hospital Southeast University
2023
Shanghai Tenth People's Hospital
2023
Tongji University
2023
Shandong University
2016-2021
Northeast Normal University
2021
Anhui Medical University
2021
Drug resistance is one of the major obstacles for improving prognosis breast cancer patients. Increasing evidence has linked association aberrantly expressed microRNAs (miRNAs) with tumour development and progression as well chemoresistance. Despite recent advances, there still little known about potential role mechanism miRNAs in Here we describe that 16 were found to be significantly down-regulated 11 up-regulated drug-resistant tissues compared drug-sensitive tissues, using a miRNA...
The differentiation of adipose tissue-derived stromal cells (ADSCs) into adipocytes involves a highly orchestrated series events that includes cell lineage commitment, mitotic clonal expansion, growth arrest, and terminal differentiation. However, the molecular mechanisms controlling adipogenesis are not yet completely understood. In this study, we investigated whether microRNAs (miRNAs) play role in adipocyte Microarray analysis was performed to determine miRNA expression profile during...
Objective. To identify the shared genetic and epigenetic mechanisms between osteogenic differentiation of dental pulp stem cells (DPSC) bone marrow (BMSC). Materials Methods. The profiling datasets miRNA expression in mesenchymal from (BMSC) were searched Gene Expression Omnibus (GEO) database. differential analysis was performed to differentially expressed miRNAs (DEmiRNAs) dysregulated DPSC BMSC osteodifferentiation. target genes DEmiRNAs that osteodifferentiation identified, followed by...
Streptococcus mutans (S. mutans), the prime pathogen of dental caries, can secrete glucosyltransferases (GTFs) to synthesize extracellular polysaccharides (EPSs), which are virulence determinants cariogenic biofilms. Ursolic acid, a type pentacyclic triterpene natural compound, has shown potential antibiofilm effects on S. mutans. To investigate mechanisms ursolic acid-mediated inhibition biofilm formation, we first demonstrated that acid could decrease viability and structural integrity...
Objective. To investigate the genetic crosstalk mechanisms that link periodontitis and Alzheimer’s disease (AD). Background. Periodontitis, a common oral infectious disease, is associated with (AD) considered putative contributory factor to its progression. However, comprehensive investigation of potential shared between these diseases has not yet been reported. Methods. Gene expression datasets related were downloaded from Expression Omnibus (GEO) database, differential analysis was...
The liver is the central organ for metabolism and influence growth development of animals. To date, little known about microRNA (miRNA) in pigeon livers, particularly different developmental stages. A comprehensive investigation into miRNA transcriptomes livers across 3 stages (1, 14, 28 d old) an adult stage (2 y was performed by small RNA sequencing. We identified 312 miRNA, 433 conserved 192 novel livers. set differentially expressed (DE) were screened out during development. This might...
An miR-21 silencing strategy based on a polymeric vector-mediated delivery system was developed for the effective treatment of human prostate cancer.
Abstract Early diagnosis of breast cancer remains a major clinical challenge. Liquid biopsy has become powerful tool for by the aid various state-of-the-art detection technologies and artificial intelligence (AI) methods. Although prediction performance is superior, application existing AI models greatly limited due to their poor interpretability. Here, we designed miRNA-Gene-Module-Pathway-Disease biological decoding path, developed BioDecoder thereof, miRNA bio-interpretable neural network...
The tumor microenvironment (TME) affected the prognosis of tumors. However, its effect on outcomes obese endometrial cancer (EC) patients had not been reported.
尖孢镰刀菌古巴专化型4号小种（Fusarium oxysporum f.sp. cubense race 4，Foc4）是香蕉枯萎病的强致病性病原菌。Foc4在侵染香蕉植株早期必须面对寄主的活性氧迸发。 目的了解Foc4应对外源氧化胁迫的分子机制。 方法利用Illumina 2500 RNA-Seq测序平台分析了经外源氧化胁迫（H2O2）处理的Foc4与对照在转录组水平的基因表达差异。 结果在外源氧化胁迫条件下，Foc4的生长受到抑制。转录组测序获得了超过2千万条clean reads。进一步的差异基因表达分析以差异倍数FC（fold change）≥ 2且FDA值≤...
Background: The risk of malignant transformation enchondromas (EC) toward central chondrosarcoma is increased up to 35%, while the exact etiology EC unknown. purpose this research was authenticate gene signatures during and reveal their potential mechanisms in occurrence development EC. Methods: expression profiles acquired from Gene Expression Omnibus database (no. GSE22855). ontology (GO), protein–protein interaction (PPI) network Kyoto Encyclopedia Genes Genomes pathway (KEGG) enrichment...
Abstract Background Titanium dioxide (TiO 2 ) nanotubes can improve the osseointegration of pure titanium implants, but this exact mechanism has not been fully elucidated. The purinergic receptor P2Y6 is expressed in bone marrow mesenchymal stem cells (BMSCs) and participates regulation metabolism. However, it unclear as to whether involved osteogenic differentiation BMSCs induced by TiO nanotubes. Methods were prepared on surface specimens using anodizing method. morphology was observed a...