A5034091158- Sarcoidosis and Beryllium Toxicity Research
- Cardiac Imaging and Diagnostics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Structural Anomalies and Repair
- Advanced MRI Techniques and Applications
- Cardiac pacing and defibrillation studies
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Effects of Exercise
- Atrial Fibrillation Management and Outcomes
- Cardiomyopathy and Myosin Studies
- Occupational exposure and asthma
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Atomic and Subatomic Physics Research
- Cardiac electrophysiology and arrhythmias
- Cardiac tumors and thrombi
- Vasculitis and related conditions
- Mitochondrial Function and Pathology
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Coronary Artery Anomalies
- Ultrasound and Hyperthermia Applications
- Cardiovascular Issues in Pregnancy
- Tracheal and airway disorders
Harefield Hospital
2021-2024
Royal Brompton Hospital
2019-2024
Guy's and St Thomas' NHS Foundation Trust
2021-2024
Imperial College London
2020-2024
Lung Institute
2024
Transnational Press London
2022
Royal Brompton & Harefield NHS Foundation Trust
2020
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2017
University of Messina
2017
University of Sassari
2013
Cardiac sarcoidosis (CS) is a potentially fatal condition that varies in its clinical presentation. Here, we describe baseline characteristics at presentation along with prognosis and predictors of outcome sizable deeply phenotyped contemporary cohort CS patients.
Cardiac sarcoidosis is associated with significant morbidity and mortality. Immunosuppressive treatment focuses on suppressing myocardial inflammation, which can lead to major adverse events especially when progressing fibrosis. Conventional management usually includes steroids steroid sparing agents such as methotrexate azathioprine. Tumour necrosis factor alpha inhibitors are often reserved for those a worsening clinical status and/or evidence of persistent inflammatory activity despite...
In patients with cardiac sarcoidosis (CS), implantable cardioverter-defibrillators (ICDs) are important for preventing sudden death. This study aimed to investigate sex disparities in CS undergoing ICD implantation.
Abstract Background and Aims Microstructural disturbances underlie dysfunctional contraction adverse left ventricular (LV) remodelling after ST-elevation myocardial infarction (STEMI). Biphasic diffusion tensor cardiovascular magnetic resonance (DT-CMR) quantifies dynamic reorientation of sheetlets (E2A) from diastole to systole during thickening, markers tissue integrity [mean diffusivity (MD) fractional anisotropy (FA)]. This study investigated whether microstructural alterations...
Introduction Sarcoidosis is a systemic inflammatory disorder characterised by non-caseating granulomas. Cardiac sarcoidosis (CS) normally causes conduction abnormalities, ventricular arrhythmias, and heart failure. Little known about the characteristics impact of in patients admitted with ST-elevation myocardial infarction (STEMI). This study aims to fill this void. Material methods Utilising National Inpatient Sample (NIS) database (2016–2020), individuals STEMI were identified categorised...
In cardiac sarcoidosis (CS) patients, the benefit of resynchronization therapy (CRT) remains unclear. We sought to assess short-term and long-term effects CRT in CS patients with a range left ventricular (LV) ejection fractions (LVEFs).
Background Echocardiography, cardiac magnetic resonance and 18 fluorodeoxyglucose positron emission tomography (FDG-PET) imaging play key roles in the diagnosis management of sarcoidosis (CS), but relative value each modality predicting outcomes has yet to be determined. This study sought determine prognostic importance multimodality data over above demographic characteristics left ventricular ejection fraction (LVEF). Methods Consecutive patients newly diagnosed with CS were included....
Eosinophilic heart disease (EHD) is a rare cardiac condition with wide spectrum of phenotypes. The diagnostic and prognostic value magnetic resonance (CMR) in EHD remains unknown.This was retrospective analysis 250 patients eosinophilia referred for CMR scan (period 2000-2020). data sets clinical/laboratory were collected. Patients followed up mean 24 months (range 1-224) the composite endpoint death, acute coronary syndrome, hospitalization failure, malignant ventricular arrhythmias, or...
Abstract Aims Cardiovascular magnetic resonance (CMR) is valuable for the detection of cardiac involvement in neuromuscular diseases (NMDs). We explored value 2D- and 3D-left ventricular (LV) myocardial strain analysis using feature-tracking (FT)-CMR to detect subclinical NMD. Methods results The study included retrospective 111 patients with NMD; mitochondrial cytopathies (n = 14), Friedreich’s ataxia (FA, n 27), myotonic dystrophy Becker/Duchenne’s muscular (BMD/DMD, 15), Duchenne’s...
Objective Cardiac sarcoidosis (CS) may present with cardiac arrest or life-threatening arrhythmias. There are limited data on this subgroup of patients CS. Advanced imaging including cardiovascular magnetic resonance (CMR) and 18-fluorodeoxyglucose (FDG) positron emission tomography (PET) used for diagnosis. This study aimed to describe advanced patterns suggestive CS among presenting Methods An database a referral centre (Royal Brompton Hospital, London) was screened arrhythmias having...
There is conflicting evidence regarding the response to a fixed dose of regadenoson in patients with high body weight. The aim this study was evaluate effectiveness varying weights using novel quantitative CMR perfusion parameters addition standard clinical markers. Consecutive typical angina and/or risk factors for coronary artery disease (N=217) underwent stress imaging dual-sequence protocol generated from an artificial intelligence (AI) based algorithm. performed on 1.5 T scanners 0.4 mg...
Journal Article Straddle embolus--imminent paradoxical embolus diagnosed by echocardiography and treated surgically Get access European of Cardio-Thoracic Surgery, Volume 5, Issue 2, February 1991, Pages 105–107, https://doi.org/10.1016/1010-7940(91)90008-8 Published: 01 1991
Post-pericardiectomy right ventricular (RV) failure has been reported but it remains not well-studied. To investigate imaging parameters that could predict RV function and the outcome of patients post-pericardiectomy.We analysed data from a total 53 CP undergoing pericardiectomy. Preoperative, early at 6 months postoperative echocardiographic (echo) datasets were correlated with preoperative cardiac magnetic resonance (CMR), computed tomography scans histology. The primary endpoint study was...
We report a case of penetrating intrapericardial injury caused by an air gun pellet in which the onset dysrhythmia suggested that pericardium had been breached. Electrocardiographic changes appeared to be more useful diagnosing pericardial penetration than transthoracic echocardiogram this case.
We report an unusual clinical case of a 66-year-old patient with cardiac involvement from metastatic melanoma, causing the formation large right atrial mass extensive infiltration free wall, interatrial septum, coronary sinus, and up to mitral annulus posterior wall ventricle, unamendable complete surgical excision. As secondary tumors are not part routine daily practice, we thought that this would be good educational opportunity for practicing clinicians, both specialists nonspecialists.