A5038610929- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Airway Management and Intubation Techniques
- Teratomas and Epidermoid Cysts
- Vascular Malformations and Hemangiomas
- Sleep and Wakefulness Research
- Vitamin D Research Studies
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Liver Disease and Transplantation
- Neuroblastoma Research and Treatments
- Pancreatic and Hepatic Oncology Research
Children's Hospital of Fudan University
2017-2024
Fudan University
2014
Abstract To investigate the mechanism of 25 hydroxyvitamin D (25(OH)D) deficiency in children with biliary atresia (BA) and its effect on liver fibrosis. The serum vitamin 25(OH)D, expression hydroxylase (CYP2R1 CYP27A1) BA patients were detected compared those control group. We investigated differential CYP2R1 hepatocytes genes related to fibrosis primary hepatic stellate cells (HSCs) animal models cholestasis. ratio 25(OH)D/vitamin group was significantly lower than that mRNA protein...
To detail the effects of vitamin D (VD) deficiency and assess relationships between VD liver function fibrosis in patients with biliary atresia (BA). In this study, BA confirmed by intraoperative cholangiography were enrolled January 2017 February 2019. Preoperative serum 25-(OH)D level, function, biomarker levels fibrosis, histopathologic features recorded. Deficiency, insufficiency, sufficiency defined as concentrations <10, 10-20, >20 ng/ml, respectively. Associations level analyzed. A...
Children with severe obstructive sleep apnea syndrome (OSAS) are more sensitive to opioids. Identifying such children and reducing or even eliminating opioids necessary but difficult. We have previously shown that patients intraoperative fentanyl require less postoperatively.The objective of this study was evaluate the performance a postinduction test in identifying syndrome.A prospective, observational, assessor-blinded carried out 104 assessed undergoing elective adenotonsillectomy....
We measured pre-operative hepatic blood flow and postoperative morphine concentration in infants with or without biliary atresia. Thirty-four (0-3 months) atresia undergoing portoenterostomy (Kasai operation) were included was assessed by magnetic resonance imaging before surgery 12 of them. Sixteen subjects liver disease abdominal pelvic acted as controls six them had assessed. Intravenous (8 μg.kg(-1).h(-1)) administered to all patients postoperatively. The median (IQR [range]) relative...
The objective of this study is to summarize the clinical characteristics and management rare diseases colorectal vascular malformation (CRVM) in children. We retrospectively analyzed data CRVM patients admitted Children's Hospital Fudan University from 2004 2019. A total 23 cases (16 males, 7 females) were enrolled. median age symptom onset was 1.4 years. Hematochezia anemia cardinal symptoms. Fourteen (60.9%) misdiagnosed as anal fissures (n = 4), internal hemorrhoids 3), rectal polyps 2),...
Abstract Background It has been proposed that the dose of rescue opioids should be individually titrated to severity obstructive sleep apnea after adenotonsillectomy. However, a study is not always available before This randomized, controlled and blinded trial evaluated strategy pain control individualized results fentanyl test, rather than polysomnography, in children Methods A total 280 (3–10 years old) undergoing elective adenotonsillectomy were randomized into an protocol (IP) group or...