A5074499800- MicroRNA in disease regulation
- Circular RNAs in diseases
- Genomics, phytochemicals, and oxidative stress
- RNA Research and Splicing
University of Nevada, Reno
2022-2025
Circular RNAs (circRNAs) are non-coding mostly derived from exons of protein-coding genes via a back-splicing process. The expression hundreds circRNAs accumulates during healthy aging and is associated with Alzheimer’s disease (AD), which characterized by the accumulation amyloid-beta (Aβ) proteins. In C. elegans , many were previously found to accumulate aging, loss age-accumulated CREB gene (circ- crh-1 ) increase mean lifespan. Here, we used study effects on age-related onset...
Abstract Accumulation of circular RNAs (circRNAs) during aging occurs on a genome‐wide level for multiple organisms, but its significance is unknown. Generating circRNA loss‐of‐function mutants difficult because the vast majority these are comprised exons shared with protein‐coding mRNAs. In Caenorhabditis elegans , most circRNAs were previously found to accumulate aging. Two abundant, age‐accumulating generated from exon 4 crh ‐ 1 gene (circ‐ ). Here, we that biogenesis circ‐ was regulated...
ABSTRACT Circular RNAs (circRNAs) are non-coding mostly derived from exons of protein-coding genes via a back-splicing process. The expression hundreds circRNAs accumulates during healthy aging and is associated with Alzheimer’s disease (AD), characterized by the accumulation amyloid-beta (Aβ) proteins. In C. elegans , many were previously found to accumulate aging, loss age-accumulated CREB gene (circ- crh-1 ) increase mean lifespan. Here, we used study effects on age-related onset...