A5068512145- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Autoimmune and Inflammatory Disorders
- Immunodeficiency and Autoimmune Disorders
- Galectins and Cancer Biology
- Pregnancy and Medication Impact
- Diverticular Disease and Complications
- Veterinary medicine and infectious diseases
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Chronic Lymphocytic Leukemia Research
- Pharmaceutical studies and practices
- Celiac Disease Research and Management
- Gastroesophageal reflux and treatments
- Biosimilars and Bioanalytical Methods
- Microbial Metabolites in Food Biotechnology
- Gastrointestinal motility and disorders
- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
- Liver Diseases and Immunity
- Escherichia coli research studies
- Autoimmune and Inflammatory Disorders Research
- Clostridium difficile and Clostridium perfringens research
University of Lausanne
2011-2024
Cabinet Gastroenterology La Source-Beaulieu
2010-2024
Swiss HIV Cohort Study
2023
University Hospital of Lausanne
2013-2022
Générale-Beaulieu Clinic
2018-2022
University of Zurich
2021-2022
University Hospital of Zurich
2021-2022
Clinique de La Source
2013-2020
Crohn's and Colitis UK
2018
Groupe d'Étude Thérapeutique des Affections Inflammatoires du Tube Digestif
2018
This paper is the second in a series of three publications relating to European evidence-based consensus on diagnosis and management Crohn's disease concerns active disease, maintenance medically induced remission surgery. The aims methods ECCO Consensus, as well sections classification are covered first [van Assche et al. JCC 2009a]. final covers post-operative recurrence, fistulating paediatric adolescent IBD, pregnancy, psychosomatics, extraintestinal manifestations complementary or...
Crohn's disease (CD) is a chronic progressive destructive disease. Currently available instruments measure activity at specific point in time. An instrument to cumulative structural damage the bowel, which may predict long-term disability, needed. The aim of this article outline methods develop an that can bowel damage. project being conducted by International Program New Indexes (IPNIC) group. This instrument, called Disease Digestive Damage Score (the Lémann score), should take into...
BackgroundData evaluating the chronological order of appearance extraintestinal manifestations (EIMs) relative to time inflammatory bowel disease (IBD) diagnosis is currently lacking. We aimed assess type, frequency, and EIMs in patients with IBD.
The diagnosis of inflammatory bowel disease (IBD), comprising Crohn's (CD) and ulcerative colitis (UC), continues to present difficulties due unspecific symptoms limited test accuracies. We aimed determine the diagnostic delay (time from first IBD diagnosis) identify associated risk factors. A total 1591 patients (932 CD, 625 UC, 34 indeterminate colitis) Swiss cohort study (SIBDCS) were evaluated. SIBDCS collects data on a large sample hospitals private practice across Switzerland through...
Hybridomas producing monoclonal immunoglobulin A (IgA) antibodies against Salmonella typhimurium were generated by mucosal immunization of BALB/c mice with attenuated strains S. and subsequent fusion Peyer's patch lymphoblasts myeloma cells. To test the role secretory IgA (sIgA) in protection sp., we analyzed detail protective capacity a IgA, Sal4, produced polymeric as well monomeric forms, that is directed carbohydrate epitope exposed on surface typhimurium. bearing subcutaneous Sal4...
<i>Background:</i> Specific strains of <i>Lactobacillus acidophilus</i> are known to inhibit intestinal cell adhesion and invasion by enterovirulent bacteria. As <i>L. can survive transiently in the human stomach, it may downregulate <i>Helicobacter pylori</i> infection. <i>Methods:</i> The ability acidophilus (johnsonii)</i> La1 supernatant interfere with <i>H. pylori </i>bacterial growth, urease activity, epithelial...
### 8.1 General Proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the procedure of choice for most patients ulcerative colitis (UC) requiring colectomy.1 Pouchitis a non-specific inflammation reservoir and common complication IPAA in UC.2–7 Its frequency related to duration follow-up, occurring up 50% 10 years after large series from major referral centres.1–9 The cumulative incidence pouchitis an familial adenomatous polyposis much lower, ranging 0 10%.10–12 Reasons higher UC...
M cells of intestinal epithelia overlying lymphoid follicles endocytose luminal macromolecules and microorganisms deliver them to underlying tissue. The effect secretory IgA antibodies on adherence transepithelial transport antigens by is unknown. We have studied the interaction monoclonal directed against specific enteric viruses, or hapten trinitrophenyl (TNP), with cells. To produce monospecific mouse mammary tumor virus (MMTV) reovirus type 1, Peyer's patch from mucosally immunized mice...
ABSTRACT Saccharomyces boulardii is a nonpathogenic yeast that protects against antibiotic-associated diarrhea and recurrent Clostridium difficile colitis. The administration of C. toxoid A by gavage to S. -fed BALB/c mice caused 1.8-fold increase in total small intestinal immunoglobulin levels ( P = 0.003) 4.4-fold specific anti-toxin < 0.001). Enhancing host immune responses may be an important mechanism for -mediated protection diarrheal illnesses.
The supernatant of Lactobacillus johnsonii La1 culture was shown to be bactericidal and have a partial, acid-independent suppressive effect on Helicobacter pylori in humans. aim the present study investigate L. La1-acidified milk (LC-1) H. infection.Fifty-three volunteers infected with as determined by positive 13C-urea breath test serology were randomized receive either LC-1 or placebo 180 ml twice day for 3 weeks. All subjects also received clarithromycin 500 mg bid during last two weeks...
The aim of this study was to assess our clinical experience with infliximab, a monoclonal antitumor necrosis factor antibody, following its approval for treatment refractory Crohn's disease (CD).We followed 100 consecutive patients CD (53 women and 47 men; mean age, 41 yr) who received total 233 infliximab (5 mg/kg) infusions. Adverse events were noted response assessed every 2 wk 6 months after each infusion using the Harvey Bradshaw Index (HBI) active disease, Perianal Disease Activity...
OBJECTIVES: The impact of diagnostic delay (a period from appearance first symptoms to diagnosis) on the clinical course Crohn's disease (CD) is unknown. We examined whether length affects outcomes. METHODS: Data Swiss IBD cohort study were analyzed. Patients recruited university centers (68%), regional hospitals (14%), and private practices (18%). frequencies occurrence bowel stenoses, internal fistulas, perianal CD-related surgery (intestinal perianal) RESULTS: A total 905 CD patients...
The Wiskott-Aldrich syndrome, a primary human immunodeficiency, results from defective expression of the hematopoietic-specific cytoskeletal regulator syndrome protein (WASP). Because CD4+CD25+Foxp3+ naturally occurring regulatory T (nTreg) cells control autoimmunity, we asked whether colitis in WASP knockout (WKO) mice is associated with aberrant development/function nTreg cells. We show that WKO have decreased numbers both thymus and peripheral lymphoid organs. Moreover, demonstrate are...