A5061701761- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Forensic Anthropology and Bioarchaeology Studies
- Forensic and Genetic Research
- Medical Imaging Techniques and Applications
- Archaeological Research and Protection
- Archaeology and ancient environmental studies
- Prostate Cancer Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Radiation Dose and Imaging
- Radiation Effects and Dosimetry
- Bladder and Urothelial Cancer Treatments
- Forensic Entomology and Diptera Studies
- Radiomics and Machine Learning in Medical Imaging
- Disaster Response and Management
- Paleopathology and ancient diseases
- Atomic and Subatomic Physics Research
- Yersinia bacterium, plague, ectoparasites research
- Cutaneous Melanoma Detection and Management
- Autopsy Techniques and Outcomes
- Ancient Mediterranean Archaeology and History
- Renal cell carcinoma treatment
- Lung Cancer Diagnosis and Treatment
- Particle accelerators and beam dynamics
- Melanoma and MAPK Pathways
Bournemouth University
2008-2024
Institute of Cancer Research
2014-2022
Royal Marsden NHS Foundation Trust
2014-2022
Marshall Space Flight Center
2022
Duke Medical Center
2021
Wake Forest University
2021
Johns Hopkins University
2021
American Association of Physicists in Medicine
2021
Ashland (United States)
2021
John Wiley & Sons (United States)
2021
Atmospheric aerosol formation is known to occur almost all over the world, and importance of these particles climate air quality has been recognized. Although processes driving take place below a particle diameter 3 nanometers, observations cover only larger particles. We introduce an instrumental setup measure atmospheric concentrations both neutral charged nanometer-sized clusters. By applying instruments in field, we come three important conclusions: (i) A pool numerous clusters sub–3...
IntroductionMR-guided adapted radiotherapy (MRgART) using a high field MR-linac has recently become available. We report the estimated delivered fractional dose of first five prostate cancer patients treated at our centre MRgART and compare this to C-Arm linac daily Image Guided Radiotherapy (IGRT).MethodsPatients were treatment plans shaped their anatomy. The treatments recalculated on an MR image acquired immediately prior delivery in order estimate dose. C-arm non-adapted VMAT same images...
Whole bladder magnetic resonance image-guided radiotherapy using the 1.5 Telsa MR-linac is feasible. Full online adaptive planning workflow based on anatomy seen at each fraction was performed. This delivered within 45 min. Intra-fraction filling did not compromise target coverage. Patients reported acceptable tolerance of treatment.
Purpose: Portal dosimetry provides an accurate and convenient means of verifying dose delivered to the patient. A simple method for carrying out portal volumetric modulated arc therapy (VMAT) is described, together with phantom measurements demonstrating validity approach. Methods: images were predicted by projecting in isocentric plane through image plane, exponential attenuation convolution a double‐Gaussian scatter function. Appropriate parameters projection selected fitting calculation...
The potential for contextual information to bias assessments in the forensic sciences has been demonstrated, several disiplines. In this paper, biasability within anthropology was examined by analyzing effects of external manipulations on judgments and decision-making visual trauma assessment. Three separate websites were created containing fourteen identical images. Participants randomly assigned one website. Each website provided different information, assess variation interpretation same...
In the forward-projection method of portal dosimetry for volumetric modulated arc therapy (VMAT), integrated signal at electronic imaging device (EPID) is predicted time treatment planning, against which measured image compared. back-projection method, each gantry angle back-projected through patient CT scan to give a measure total dose patient. This study aims investigate practical agreement between two types EPID prostate radiotherapy. The AutoBeam planning system produced VMAT plans...
Dosimetric quality assurance (QA) of the new Elekta Unity (MR-linac) will differ from QA performed a conventional linac due to constant magnetic field, which creates an electron return effect (ERE). In this work we aim validate PRESAGE
To describe the clinicopathological and immunohistochemical features of cutaneous malignant melanomas with a pure or mixed small-cell pattern in 11 adult patients, to discuss diagnostic difficulties encountered.Haematoxylin eosin-stained sections each case melanoma, together locally recurrent skin lesions and, where available, metastatic deposits, were re-examined. Available evaluated. Clinical follow-up data obtained case. One patient presented disease, others lesions. Suggested initial...
Using an Electronic Portal Imaging Device (EPID) to perform in-vivo dosimetry is one of the most effective and efficient methods verifying safe delivery complex radiotherapy treatments. Previous work has detailed development EPID based system that was subsequently used replace pre-treatment dose verification IMRT VMAT plans. Here we show this can be readily implemented on a commercial megavoltage imaging platform without modification hardware impacting standard procedures. The accuracy...
Abstract The process of archaeological excavation is one destruction. It normally provides archaeologists with a singular opportunity to recognise, define, extract and record evidence: the artefacts, features deposits present in record. expected that when are excavating research, commercial or forensic setting methods they utilise will ensure high rate evidence recognition recovery. Methods need be accepted amongst scientific community serving deemed reliable. For example, contexts, conform...
Background and purposeReal-time portal dosimetry compares measured images with predicted to detect delivery errors as the radiotherapy treatment proceeds. This work aimed investigate performance of a recurrent neural network for processing image metrics so early possible in treatment.Materials methodsVolumetric modulated arc therapy (VMAT) plans six prostate patients were used generate sequences images. Errors introduced into modified delivered water-equivalent phantom. Four different...
Sclerosing epithelioid fibrosarcoma is a recently described sarcoma in which ultrastructural evidence of fibroblastic differentiation forms part the diagnostic criteria.This report describes further case this tumour, showed both and perineurial diVerentiation by immunohistochemistry electron microscopy, had areas high grade morphology.The tumour metastasised patient died disease 12 months after presentation.The relevance these findings to diagnosis tumours discussed.
Delivering selected parts of volumetric modulated arc therapy (VMAT) plans using step-and-shoot intensity radiotherapy (IMRT) beams has the potential to increase plan quality by allowing specific aperture positioning. This study investigates treatment and accuracy in vivo portal dosimetry such a hybrid approach for case prostate radiotherapy.
A rare case of anal intraepithelial neoplasia arising in an inflammatory cloacogenic polyp is reported. While the occurrence complicating benign conditions recognised, this re-emphasises need for careful histological examination all perianal lesions.
The site of Akanthou-Arkosykos, also known as Tatlısu-Çiftlikdüzü, (henceforth Akanthou) located on the north coast Cyprus, been dated to Early Aceramic Neolithic or Cypro-PPNB/MPPNB 8200–7700 BC. It has revealed one most important early sites Cyprus. Rescue excavations since 2000 were undertaken assess and protect it from agricultural damage threats construction. is now a scheduled monument protected under Antiquities law. Despite plough other there excellent preservation. have six...