A5084126830- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Connective tissue disorders research
- Hormonal Regulation and Hypertension
- Cardiac Valve Diseases and Treatments
- Pharmacological Effects and Assays
- Kawasaki Disease and Coronary Complications
- Renin-Angiotensin System Studies
- Natural Compound Pharmacology Studies
- Stress Responses and Cortisol
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Cardiac, Anesthesia and Surgical Outcomes
- Apelin-related biomedical research
- Bipolar Disorder and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Electroconvulsive Therapy Studies
- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Microbial metabolism and enzyme function
- Cancer-related molecular mechanisms research
- Coronary Artery Anomalies
- Agricultural Economics and Policy
- Atherosclerosis and Cardiovascular Diseases
- Advanced Glycation End Products research
University of Kentucky
2019-2025
Cardiovascular Research Center
2022-2024
Cedars-Sinai Medical Center
2019-2023
California State University, Long Beach
2016-2019
Florida College
2019
University of Florida
2019
University of Minnesota
2018
Louisiana State University Health Sciences Center Shreveport
2017-2018
Oxford Brookes University
2006-2017
University of Oxford
1977-2005
Localized Lyme disease, manifested by erythema migrans, is usually treated with oral doxycycline or amoxicillin. Whether acute disseminated Borrelia burgdorferi infection should be differently from localized unknown.
Background: The ascending aorta is a common location for aneurysm and dissection. This aortic region populated by mosaic of medial adventitial cells that are embryonically derived from either the second heart field (SHF) or cardiac neural crest. SHF-derived populate areas coincide with spatial specificity thoracic aortopathies. purpose this study was to determine whether how contribute Methods: Ascending pathologies were examined in patients sporadic aortopathies angiotensin II...
β-aminopropionitrile (BAPN) is a pharmacological inhibitor of LOX (lysyl oxidase) and LOXLs (LOX-like proteins). Administration BAPN promotes aortopathies, although there paucity data on experimental conditions to generate pathology. The objective this study was define parameters determine whether equivalent or variable aortopathies were generated throughout the aortic tree during administration in mice.
Abstract Nicotine directly regulates striatal dopamine ( DA ) neurotransmission via presynaptic nicotinic acetylcholine receptors (n AC h R s) that are α6β2 and/or α4β2 subunit‐containing, depending on region. Chronic nicotine exposure in smokers upregulates n density, with some reports suggesting differential impact α6‐ or α4‐containing s. Here, we explored whether chronic modifies transmission, the effects of acute release probability persist and there modifications to regulation by...
ABSTRACT Thoracic aortopathies are life-threatening diseases including aneurysm, dissection, and rupture. Phosphodiesterases (PDEs) regulate intracellular cyclic nucleotide concentrations. Recent studies report the influences of cilostazol, a PDE3 inhibitor, sildenafil, PDE5 on abdominal aortic aneurysm formation. However, their impacts thoracic aortopathy remain unknown. In this study, we investigated whether cilostazol sildenafil affect induced by β-aminopropionitrile (BAPN) administration...
including the intact drug itself but that conditions during second period of dosing were not such as to precipitate reaction.The present findings, however, do exclude possibility toxic metabolite formation is responsible for adverse effects practolol, since these might be produced only in very small amounts, highly reactive and covalently bound (Orton & Lowery, 1977) readily detectable by methods used here.
Objective: A cardinal feature of Marfan syndrome is thoracic aortic aneurysm. The contribution the renin-angiotensin system via AT1aR (Ang II [angiotensin II] receptor type 1a) to aneurysm progression remains controversial because beneficial effects angiotensin blockers have been ascribed off-target effects. This study used genetic and pharmacological modes attenuating ligand, respectively, determine their roles on in mice with fibrillin-1 haploinsufficiency ( Fbn1 C1041G/+ ). Approach...
Nineteen patients with acute psychoses, the majority schizophrenics, were studied in course of chlorpromazine (CPZ) treatment. Plasma levels drug, plasma prolactin (PRL), extrapyramidal side-effects (EPS) and changes mental state monitored weekly, as our earlier study. The results confirm some previous findings: (a) CPZ vary widely among correlate poorly daily doses CPZ; (b) increased PRL is associated higher more common who develop EPS; (c) none these three variables differ between groups...
Depression is a serious condition that occurs more frequently in women and often associated with treatment resistance. The main hypotheses of this study are (a) aldosterone an early marker depression onset (b) tryptophan (TRP) depletion model previously validated male rats resistant females. To explore possible underlying mechanisms, we have focused on factors shown to be altered patients treatment-resistant depression. Female Sprague-Dawley were treated control or low-TRP-containing diet...
Cross-linking of lysine residues in elastic and collagen fibers is a vital process aortic development. Inhibition lysyl oxidase by BAPN (β-aminopropionitrile) leads to thoracic aortopathies mice. Although the renin-angiotensin system contributes several types aortopathies, it remains unclear whether inhibition protects against aortopathy caused impairment fiber/collagen crosslinking.BAPN (0.5% wt/vol) was started drinking water induce male C57BL/6J mice at 4 weeks age for weeks. Five...
Atherosclerosis is a leading cause of morbidity and mortality in many countries. Mice are the most frequently used animal model to study pathogenesis molecular mechanisms atherosclerosis. En face analyses aorta cross-sections aortic root two common modes for quantifying severity atherosclerosis mice. This mini-review introduces these methods, discusses their pros cons, provides suggestions optimize quantification atherosclerosis, thereby enhancing rigor reproducibility preclinical research.
Summary The plasma prolactin (PRL) response to haloperidol 2 or 4 mg i.m. was studied in 18 schizophrenic men during their routine treatment with neuroleptic drugs. A substantial rise of the PRL level above baseline occurred all but four 20 tests showing that elevation induced by not maximal. challenge ineffective only patients receiving very high daily doses medication. increment inversely correlated dose medication unrelated concentrations test. Chronic schizophrenics who were long term...
BACKGROUND: Pharmacological inhibition of megalin (also known as LRP2 [low-density lipoprotein receptor-related protein-2]) attenuates atherosclerosis in hypercholesterolemic mice. Since is abundant renal proximal tubule cells (PTCs), the purpose this study was to determine whether PTC-specific deletion reduces hypercholesterolemia-induced METHODS: Female Lrp2 f/f mice were bred with male Ndrg1 - Cre ERT2 +/0 develop PTC-LRP2 +/+ and −/− littermates. To atherosclerosis, all an LDL...