A5043194543- Microbial Metabolic Engineering and Bioproduction
- Enzyme Catalysis and Immobilization
- Enzyme Structure and Function
- Diet and metabolism studies
- Biofuel production and bioconversion
- Protein Structure and Dynamics
- Soil Carbon and Nitrogen Dynamics
- Metal-Catalyzed Oxygenation Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Metabolism and Genetic Disorders
- Microbial Community Ecology and Physiology
UiT The Arctic University of Norway
2020
Uppsala University
2018
ADH-A from Rhodococcus ruber DSM 44541 catalyzes the oxidation of (S)-1-phenylethanol 3000-fold more efficiently as compared with 2-hydroxylated derivative (R)-phenylethane-1,2-diol. The enzyme is also highly selective for sec-alcohols comparably low activities corresponding primary alcohols. When challenged a substrate containing two secondary alcohols, such 1-phenylpropane-(1R,2S)-diol, favors benzylic carbon this alcohol. catalytic efficiency, however, modest in comparison to activity...
l ‐2,4‐diaminobutyric acid (DABA) aminotransferases can catalyze the formation of amines at distal ω‐position substrates, and is intial rate‐limiting enzyme in biosynthesis pathway cytoprotecting molecule ( S )‐2‐methyl‐1,4,5,6‐tetrahydro‐4‐pyrimidine carboxylic (ectoine). Although there an industrial interest ectoine, DABA remain poorly characterized. Herein, we present crystal structure EctB (2.45 Å), a aminotransferase from Chromohalobacter salexigens DSM 3043, well‐studied organism with...