A5047424428- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Immunotherapy and Immune Responses
- Signaling Pathways in Disease
- Tissue Engineering and Regenerative Medicine
- Nerve injury and regeneration
- Allergic Rhinitis and Sensitization
- Transgenic Plants and Applications
- Immune Cell Function and Interaction
- Food Allergy and Anaphylaxis Research
- vaccines and immunoinformatics approaches
Shenzhen University
2019-2021
Shenzhen Third People’s Hospital
2020
Guangzhou Medical University
2020
State Key Laboratory of Respiratory Disease
2020
Mesenchymal stem/stromal cells (MSCs) show tremendous potential for regenerative medicine due to their self-renewal, multi-differentiation and immunomodulatory capabilities. Largely studies had indicated conventional tissue-derived MSCs have considerable limited expandability donor variability which hinders further application. Induced pluripotent stem cell (iPSCs)-derived (iMSCs) created exciting source standardized cellular therapy. However, the molecular differences between iMSCs cognate...
House dust mites (HDMs) are a potent allergen source that commonly found in human living environments. While HDMs known to induce allergic diseases humans, such as asthma, its other biological activities related health less understood. Our laboratory recently purified the HDM protein PDI (protein disulfide isomerase). In this study, we assess role of contributing immune regulation. Using mass spectrometry, analyzed complexes DEC205 and extracts, induction tolerogenic dendritic cells (DCs)...
Parkinson's disease (PD), characterized by progressive degeneration of dopaminergic neurons in substantia nigra, has no disease-modifying therapy. Mesenchymal stem cell (MSC) therapy shown great promise as a solution for PD. Induced pluripotent cell-derived MSC (iMSC) not only stronger neural repair function, but also helps solve the problem heterogeneity. So we evaluated therapeutic effects iMSCs on were administered tail vein 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD models...
Pan-allergens can contribute to severity and perpetuation of allergic diseases, as a result leading IgE-medicated poly-sensitization cross-reactivity human self-antigens. Cyclophilins are well-known pan-allergens various groups cross-reactive allergens. CyPs have been identified with five classic CyP isoforms (CyPA, B, C, D E). In the present study, physicochemical immunologic characteristics were predict by bioinformatics immunoinformatics approaches. The results indicated that CyPA family...