A5018027701- Liver Disease Diagnosis and Treatment
- Clinical Nutrition and Gastroenterology
- Diet and metabolism studies
- Fatty Acid Research and Health
- Liver Disease and Transplantation
- Metabolism and Genetic Disorders
- Intestinal and Peritoneal Adhesions
- Pediatric Hepatobiliary Diseases and Treatments
- Uterine Myomas and Treatments
- Liver physiology and pathology
- Lipid metabolism and biosynthesis
- Gun Ownership and Violence Research
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Tumors and Oncological Cases
- Vascular Malformations and Hemangiomas
- Traumatic Ocular and Foreign Body Injuries
- Infant Nutrition and Health
- Gastrointestinal disorders and treatments
- Vascular Anomalies and Treatments
- Body Contouring and Surgery
- Restraint-Related Deaths
- Neonatal Respiratory Health Research
- Cardiac, Anesthesia and Surgical Outcomes
- Suicide and Self-Harm Studies
Emory University
2017-2023
Children's Healthcare of Atlanta
2017-2023
Hofstra University
2014
Harvard University
2007-2012
Boston Children's Hospital
2007-2012
Beth Israel Deaconess Medical Center
2010-2012
Center for Vascular Biology Research
2010
Harvard University Press
2009
In Brief Objective: The objective was to determine the safety and efficacy of a fish oil-based intravenous lipid emulsion (ILE) in treatment parenteral nutrition-associated liver disease (PNALD). Summary Background Data: PNALD can be lethal complication children with short bowel syndrome (SBS). ILE based on soybean oil administered nutrition (PN) may contribute its etiology. Methods: We performed an open-labeled trial 42 infants SBS who developed cholestasis (serum direct bilirubin >2 mg/dL)...
The use of fish oil-based emulsions as the sole source fat for patients receiving parenteral nutrition (PN) has raised concerns development essential fatty acid deficiency (EFAD), hindering its adoption into clinical practice. purpose present study was to examine profiles no enteral energy, while completely dependent on PN and an intravenous lipid emulsion, onset EFAD maintenance growth.Prospectively collected data from 10 were reviewed evidence EFAD, defined a triene:tetraene ratio >0.2....
Background Liver fibrosis is characterized by excessive synthesis of extracellular matrix proteins, which prevails over their enzymatic degradation, primarily metalloproteinases (MMPs). The effect pharmacological MMP inhibition on fibrogenesis, however, largely unexplored. Inflammation considered a prerequisite and important co-contributor to is, in part, mediated tumor necrosis factor (TNF)-α-converting enzyme (TACE). We hypothesized that treatment with broad-spectrum TACE-inhibitor...
Parenteral nutrition (PN) is a life-saving therapy but has been associated with dyslipidemia. Because fish oil shown to have positive effects on lipid profiles, the authors hypothesize that parenteral emulsion will improve profiles in children who are PN dependent.The examined of unique cohort 10 were exclusively administered oil-based while for median duration 14 weeks. Longitudinal data analysis generalized estimating equations approach was used determine sterol and bilirubin levels based...
Objectives : Essential fatty acids are important for growth, development, and physiologic function. α‐Linolenic acid linoleic the precursors of docosahexaenoic arachidonic acid, respectively, have traditionally been considered essential acids. However, authors hypothesized that can function as Methods Using a murine model deficiency consequent hepatic steatosis, provided mice with varying amounts to determine whether exclusive supplementation could prevent inhibit or attenuate steatosis....
Background Hepatic steatosis is an established risk factor for complications following major hepatic resection. Pharmacological options to reverse prior surgery, however, are lacking. We hypothesized that treatment with the pharmacologic tumor necrosis factor-α converting enzyme (TACE)-inhibitor Marimastat would steatosis, leading improved outcome hepatectomy. Methodology/Principal Findings C57BL/6 male mice were fed a high fat diet 9 weeks establish obesity, and insulin resistance,...
Complications from esophageal button battery impactions remain a real fear for practicing pediatric gastroenterologists and surgeons. This case describes child who developed an aorto-esophageal fistula 25 days after initial ingestion survived due to prompt placement of aortic stent via minimally invasive surgery, avoiding open procedure.A 6-year-old female presented acutely with mid-esophageal impaction witnessed by her parents. Presenting symptoms included chest pain emesis. Button location...
Paracetamol (APAP) hepatotoxicity remains the leading cause of drug-induced liver failure. Fish oil, which contains ω-3 fatty acids, has demonstrated therapeutic efficacy in several models disease. Evidence for its use APAP intoxication, however, is conflicting. The effects fish oil supplementation on APAP-induced failure were investigated.Ten C57BL6/J mice fed a diet based menhaden (MEN) or soybean (SOY) 3 weeks followed by intoxication. In second experiment, prefeeding period was reduced...
Objective: The aim of this study was to quantify and describe baseline patient parent-proxy health-related quality life scores in patients with low-flow vascular malformations at a single, tertiary-care anomalies clinic. Study design: This is retrospective data collected on between the ages 2 25 who were seen center A total 266 are included study. Results: Patients lymphatic report decreased as compared venous emotional, psychological, school, social domains. lower extremity malformation...
Anorexia nervosa is a medical and psychological disorder classically seen in young women who present with significant weight loss, distorted body image, an intense fear of gaining despite being underweight. A rare diagnosis that also associated loss trichobezoar, collection hair or hair-like fibers the gastrointestinal tract, primarily stomach. In this report, we case 14.5-year-old girl caused by initially thought to be due anorexia nervosa, review details both disorders.
Hereditary hemorrhagic telangiectasia (HHT) is an underreported autosomal dominant vascular dysplasia. Neonatal presentations of HHT are rare, as this disorder typically presents in adolescence or beyond with epistaxis. We report a female neonate hematochezia on the 1st day life secondary to multiple gastrointestinal arteriovenous malformations (AVMs) along intracranial hemorrhage. describe her clinical course and management, well novel family mutation ENG . This first reported case...
Congenital H-type tracheoesophageal fistula is a rare type of congenital malformation. In this malformation, the esophagus remains unobstructed, complicating and delaying diagnosis. We present our experience with three infants who were initially treated by minimally invasive approach via endoscopy electrocautery. Two patients ultimately required surgical procedure after failure to close electrocautery despite multiple attempts over several months. One was successfully second procedure....