A5085413991- Genetics, Aging, and Longevity in Model Organisms
- Single-cell and spatial transcriptomics
- Telomeres, Telomerase, and Senescence
- Bioinformatics and Genomic Networks
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics and Chromatin Dynamics
- Metabolomics and Mass Spectrometry Studies
- Health, Environment, Cognitive Aging
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Artificial Intelligence in Healthcare and Education
- Frailty in Older Adults
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Gene expression and cancer classification
- Osteoarthritis Treatment and Mechanisms
- Advanced Radiotherapy Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Medicinal Plants and Neuroprotection
- Head and Neck Cancer Studies
- RNA Research and Splicing
University of Rostock
2024-2025
University of Liverpool
2019-2023
Genomics (United Kingdom)
2020-2023
Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is hallmark aging and has been linked to aging-related diseases. Many genes play role cellular yet comprehensive understanding its pathways still lacking.
Abstract Ageing is a complex and multifactorial process. For two decades, the Human Genomic Resources (HAGR) have aided researchers in study of various aspects ageing its manipulation. Here, we present key features recent enhancements these resources, focusing on six main databases. One database, GenAge, focuses genes related to ageing, featuring 307 linked human 2205 associated with longevity model organisms. AnAge longevity, life-history across animal species, containing data 4645 species....
Senescent cells can spread the senescent phenotype to other by secreting senescence-associated secretory factors. The resulting paracrine make a significant contribution burden of cell accumulation with age. Previous efforts made characterize senescence are unreliable due analyses being based on mixed populations and non-senescent cells. Here, we use dipeptidyl peptidase-4 (DPP4) as surface maker isolate from populations. Using this technique, enrich percentage 40% 85%. We then enriched...
Dysregulation of intercellular communication is a hallmark aging. To better quantify and explore changes in communication, we present scDiffCom scAgeCom. an R package, relying on approximately 5,000 curated ligand-receptor interactions, that performs differential analysis between two conditions from single-cell transcriptomics data. Built upon scDiffCom, scAgeCom atlas age-related cell-cell covering 23 mouse tissues 58 RNA sequencing datasets Tabula Muris Senis the Calico murine aging cell...
A major challenge in aging research is identifying interventions that can improve lifespan and health minimize toxicity. Clinical studies cannot consider decades-long follow-up periods, therefore, in-silico evaluations using omics-based surrogate biomarkers are emerging as key tools. However, many current approaches train predictive models on observational data, rather than intervention which lead to biased conclusions. Yet, the first classifiers for extension by compounds now available,...
A major challenge in aging research is identifying interventions that can improve lifespan and health minimize toxicity. Clinical studies cannot consider decades-long follow-up periods, therefore, in-silico evaluations using omics-based surrogate biomarkers are emerging as key tools. However, many current approaches train predictive models on observational data, rather than intervention which lead to biased conclusions. Yet, the first classifiers for extension by compounds now available,...
Within primates, the great apes are outliers both in terms of body size and lifespan, since they include largest longest-lived species order. Yet, molecular bases underlying such features poorly understood. Here, we leveraged an integrated approach to investigate multiple sources variation across focusing on over 10,000 genes, including approximately 1,500 previously associated with additional 9,000 for which association longevity has never been suggested. We analyzed dN/dS rates, positive...
Abstract Dysregulation of intercellular communication is a well-established hallmark aging. To better understand how this process contributes to the aging phenotype, we built scAgeCom, comprehensive atlas presenting cell-type interactions vary with age in 23 mouse tissues. We first created an R package, scDiffCom, designed perform differential analysis between two conditions interest any or human single-cell RNA-seq dataset. The package relies on its own list curated ligand-receptor compiled...
Abstract Introduction Understanding changes in cell identity cancer and ageing is of great importance. In this work, we analyzed how gene expression human tissues are associated with tissue specificity during using transcriptome data from TCGA GTEx. Results We found significant downregulation tissue-specific genes 40% the analyzed, which suggests loss age. For most types, have noted a consistent pattern that specific to tumor originated. Moreover, observed an activation not usually expressed...
Cellular senescence (CS) and quiescence (CQ) are stress responses characterised by persistent reversible cell cycle arrest, respectively. These phenotypes heterogeneous, dependent on the type arrested insult inciting arrest. Because a universal biomarker for CS has yet to be identified, combinations of senescence-associated biomarkers linked various biological including lysosomal activity (β-galactosidase staining), inflammation (senescence-associated secretory phenotypes, SASPs), apoptosis...
ABSTRACT Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is hallmark ageing and has been linked to ageing-related diseases like cancer. Senescent cells have shown accumulate tissues aged organisms which turn can lead chronic inflammation. Many genes associated with cell yet comprehensive understanding senescence pathways still lacking. To this end, we created CellAge ( http://genomics.senescence.info/cells ), manually curated database 279 human...
Cellular senescence, a state of permanent cell cycle arrest, is associated with organismal aging and malfunctioning. Various attempts have been made to find unified gene signature for all senescence models in every type. However, more studies being conducted, none look be universally shared; instead, it seems that the cell-type specific. In present study, 74 genes commonly expressed different fibroblast derived from two independent were extracted. The shared which was functionally aging,...
Abstract Ageing is a complex and multifactorial process. For two decades, the Human Genomic Resources (HAGR) have aided researchers in study of various aspects ageing its manipulation. Here we present key features recent enhancements these resources, focusing on six main databases. One database, GenAge, focuses genes related to ageing, featuring 307 linked human 2205 associated with longevity model organisms. AnAge longevity, life-history across animal species, containing data 4645 species....
Recent advances in embryology have shown that the sister blastomeres of 2-cell mouse and human embryos differ reciprocally potency. An open question is whether became different as opposed to originating different. Here we wanted test two conflicting models: one proposing each blastomere contains both animal vegetal materials balanced proportions because plane first cleavage runs close animal-vegetal axis fertilized oocyte; other model variable can vary depending on topology fertilization....
The field of aging and longevity research is overwhelmed by vast amounts data, calling for the use Artificial Intelligence (AI), including Large Language Models (LLMs), evaluation geroprotective interventions. Such evaluations should be correct, useful, comprehensive, explainable, they consider causality, interdisciplinarity, adherence to standards, longitudinal data known biology. In particular, comprehensive analyses go beyond comparing based on canonical biomedical databases, suggesting...
This study investigates the potential risks and mechanisms of action rejuvenation therapies, focusing on metformin partial reprogramming, using an integrative approach that combines gene expression, protein interaction networks, toxicological annotations.
Abstract Within primates, the great apes are outliers both in terms of body size and lifespan, since they include largest longest-lived species order. Yet, molecular bases underlying such features poorly understood. Here, we leveraged an integrated approach to investigate multiple sources variation across focusing on ~1,550 genes previously described as tumor suppressors, oncogenes, ageing addition a novel Build CellAge database cell-senescence (version 2), herein presented for first time....