A5092937041- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Gene Regulatory Network Analysis
- Cancer Immunotherapy and Biomarkers
- Biochemical and Molecular Research
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- Cancer therapeutics and mechanisms
- HIV/AIDS drug development and treatment
Ontario Institute for Cancer Research
2023-2025
University of Toronto
2023-2024
Omics techniques generate comprehensive profiles of biomolecules in cells and tissues. However, a holistic understanding underlying systems requires joint analyses multiple data modalities. We present DPM, fusion method for integrating omics datasets using directionality significance estimates genes, transcripts, or proteins. DPM allows users to define how the input are expected interact directionally given experimental design biological relationships between datasets. prioritises genes...
Abstract Type-II topoisomerases resolve topological stress in DNA through controlled double-strand breaks. While TOP2A is a chemotherapy target proliferating cells, the ubiquitously expressed TOP2B potential off-target. Here we explore roles of mutagenesis by generating DNA-binding maps TOP2B, CTCF, and RAD21 human cancer samples analyzing these for driver mutations mutational processes 6500 whole genomes. TOP2B-CTCF-RAD21 TOP2B-RAD21 sites are enriched somatic structural variants (SVs),...
ABSTRACT Type-II topoisomerases resolve topological stress in DNA through controlled double-strand breaks. While TOP2A is a chemotherapy target proliferating cells, the ubiquitously expressed TOP2B potential off-target. Here we explore roles of mutagenesis by generating DNA-binding maps TOP2B, CTCF, and RAD21 human cancer samples analysing these for driver mutations mutational processes 6500 whole genomes. TOP2B-CTCF-RAD21 TOP2B-RAD21 sites are enriched somatic structural variants (SVs),...
Oncogenesis and tumor progression are shaped by somatic alterations in the cancer genome features of immune microenvironment (TME). How interactions these two systems influence development clinical outcomes remains incompletely understood. To address this challenge, we developed multi-omics analysis framework PACIFIC to systematically integrate genetic drivers infiltration profiles cells with information. In an 8500 samples, report 34 immunogenomic (IGXs) 13 types which context-specific...
ABSTRACT Omics techniques generate comprehensive profiles of biomolecules in cells and tissues. However, a holistic understanding the data requires joint multi-omics analyses that are challenging. Here we present DPM, fusion method for combining multiple omics datasets using directionality significance estimates genes, transcripts, or proteins. DPM allows users to define how input expected interact directionally, reflecting initial experimental design regulatory relationships between...