A5101957620- Malaria Research and Control
- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Viral Infections and Vectors
- Insect Pest Control Strategies
National University of Singapore
2023-2025
National University Health System
2023
Dengue virus (DENV) is the cause of dengue fever, infecting 390 million people worldwide per year. It transmitted to humans through bites mosquitoes and could potentially develop severe symptoms. In spite rising social economic impact inflicted by disease on global population, a conspicuous lack efficacious therapeutics against DENV still persists. this study, catechin, natural polyphenol compound, was evaluated as infection inhibitor in vitro. Through time-course studies, catechin shown...
Abstract Background Chikungunya virus (CHIKV) has reemerged as a major public health concern, causing chikungunya fever with increasing cases and neurological complications. Methods In the present study, we investigated low-passage human isolate of East/ Central/South African (ECSA) lineage CHIKV strain LK(EH)CH6708, which exhibited mix small large viral plaques. The plaque variants were isolated designated CHIKV-SP CHIKV-BP, respectively. CHIKV-BP characterized in vitro vivo to compare...
Virus genome recoding is an attenuation method that confers genetically stable by rewriting a virus with numerous silent mutations. Prior flavivirus attempts utilised codon deoptimisation approaches. However, these approaches act in species dependent manner and were unable to confer mosquito cells or animal models. To overcome limitations, we performed using the contrary approach of optimisation. The genomes flaviviruses such as dengue type 2 (DENV2) Zika (ZIKV) contain functional RNA...