A5045821088- Chemotherapy-induced organ toxicity mitigation
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
- Acute Lymphoblastic Leukemia research
- Inflammatory mediators and NSAID effects
- Natural Antidiabetic Agents Studies
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Renin-Angiotensin System Studies
- Pancreatitis Pathology and Treatment
- Reproductive Biology and Fertility
- Neurotransmitter Receptor Influence on Behavior
- Reproductive System and Pregnancy
- Liver Disease and Transplantation
- Neuroscience and Neuropharmacology Research
- Garlic and Onion Studies
- Curcumin's Biomedical Applications
- Pharmacological Effects of Medicinal Plants
- Cell death mechanisms and regulation
- Alcohol Consumption and Health Effects
- NF-κB Signaling Pathways
- Biomarkers in Disease Mechanisms
Minia University
2018-2025
Deraya University
2018-2025
Al-Azhar University
2013-2023
Al-Azhar University
2008
Assiut University
2002
Universität Innsbruck
1997-1998
Berberine (BBR) is a natural compound of plant origin belonging to isoquinoline type alkaloid. Methotrexate (MTX) an anti-metabolite used widely for variety tumors and autoimmune conditions. Clinical uses MTX were severely limited by its concomitant renal intoxication. The current study was designed investigate the efficacy BBR against MTX-induced nephrotoxicity exploring underlying molecular mechanisms through examining Keap1/Nrf2, NF-κB/P38MAPK Bax/Bcl2/caspase-3 pathways. Adults male rats...
BACKGROUND AND PURPOSE So far, there is only limited information about the regulation of endogenous synthesis hydrogen sulfide (H 2 S), an important gaseous signalling molecule. This study was done to evaluate redox‐dependent events that regulate expression H S synthesising enzyme cystathionine‐γ‐lyase (CSE) in rat mesangial cells. EXPERIMENTAL APPROACH The effects platelet‐derived growth factor (PDGF)‐BB and antioxidants on CSE activity cultured renal cells were assessed. Activity nuclear...
To investigate the function of serotonergic neurons within locus coeruleus, this brain nucleus conscious, freely moving rats was superfused with artificial cerebrospinal fluid through a push-pull cannula and extracellular concentration serotonin determined in superfusate. Serotonin release increased by depolarization veratridine (5 microM) or 80 mM K+, while superfusion tetrodotoxin (1 systemic administration 8-hydroxy-2-(di-n-propylamino)tetralin substantially diminished rate coeruleus. The...
In the present study, we have addressed possible protective role of acetyl-L-carnitine in caerulein-induced acute pancreatitis male Swiss albino rats. Acute paradigm was developed by challenging animals with a supramaximal dose caerulein (20 microg/kg, SC) four times at hourly intervals. Caerulein induced that well-characterized morphologically and biochemically. Severe oedema marked increased relative pancreatic weight, atrophy acini interacinar spaces, vacuolization, extensive leucocytic...
The interactions between 5‐hydroxytryptaminergic neurones and excitatory amino acid utilizing were studied in the locus coeruleus of conscious, freely moving rats. was superfused with artificial cerebrospinal fluid through a push‐pull cannula 5‐hydroxytryptamine (5‐HT) determined superfusate that continuously collected time periods 10 min. Superfusion NMDA receptor antagonist AP5 (10 μ M ), kynurenic (1 m or AMPA/kainate DNQX ) reduced 5‐HT release coeruleus. agonists (50 kainic AMPA...
Methotrexate (MTX) is a promising chemotherapeutic agent. Its medical use limited by induced nephropathy. Our study was designed to explore the reno-protective effect of diallyl disulfide (DADS), an organosulfur compound garlic oil, on MTX-induced Adult rats were randomly divided into 4 groups; normal control, DADS (50 mg kg–1 day–1, p.o.), MTX (20 mg/kg, i.p.) and DADS+MTX. significantly decreased serum creatinine, urea, uric acid, albumin levels with improvement final body weight....
Acute and sustained hypoxic pulmonary vasoconstriction (HPV), as well chronic hypertension (PH), is modulated by nitric oxide (NO). NO synthesis can be decreased asymmetric dimethylarginine (ADMA), which degraded dimethylaminohydrolase-1 (DDAH1). We investigated the effects of DDAH1 overexpression (DDAH1(tg)) on HPV hypoxia-induced PH. was measured during acute (10 min) (3 h) hypoxia in isolated mouse lungs. Chronic PH induced exposure mice to 4 weeks hypoxia. ADMA cyclic 3',5'-guanosine...
Aim: Renin-angiotensin system (RAS) is thought to have a noticeable effect in the pathophysiological injury multiple organs by inducing different cellular and molecular reactions. The objective of current study investigate possible protective effects perindopril against lipopolysaccharide (LPS)-induced cardiopulmonary oxidative inflammatory damage rats. Methods: To achieve this goal, animals were randomly divided into six groups: normal group, LPS group (3 mg/kg, i.p., single dose),...