A5102439606- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Genetics, Aging, and Longevity in Model Organisms
- Liver physiology and pathology
- Spaceflight effects on biology
- Marine animal studies overview
- Underwater Vehicles and Communication Systems
- Underwater Acoustics Research
- Telomeres, Telomerase, and Senescence
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
Southeast University
2024
Northwestern Polytechnical University
2013
Stage IV gastric cancer is a highly heterogeneous and lethal tumor with few therapeutic strategies. The combination of programmed cell death protein 1 inhibitors chemotherapy currently the standard frontline treatment regimen for advanced cancer. Nevertheless, it remains great challenge to screen beneficiaries immunochemotherapy expand indications this regimen.
Background: Hepatic macrophages play an indispensable role in liver pathophysiology, serving as key orchestrators of both injury and repair processes. ATG16L1 (autophagy‐related 16 like 1) has emerged a novel critical autophagy marker. In macrophages, assumes particularly crucial role. The current understanding how macrophage regulates inflammation the context fibrosis is unclear. Methods: This study included clinical patient samples established murine model with myeloid‐specific Atg16l1...
Telomere dysfunction-induced loss of genome integrity and its associated DNA damage signaling checkpoint responses are well-established drivers that cause tissue degeneration during ageing. Cancer, with incidence rates greatly increasing age, is characterized by short telomere lengths high telomerase activity. To study the roles dysfunction reactivation in ageing cancer, protocol shows how to generate two murine inducible knock-in alleles 4-Hydroxytamoxifen (4-OHT)-inducible TERT-Estrogen...