A5084936803- RNA Research and Splicing
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
Universitat Politècnica de Catalunya
2022
Barcelona Supercomputing Center
2022
Universitat Pompeu Fabra
2022
Understanding the consequences of individual transcriptome variation is fundamental to deciphering human biology and disease. We implement a statistical framework quantify contributions 21 traits as drivers gene expression alternative splicing across 46 tissues 781 individuals from Genotype-Tissue Expression project. demonstrate that ancestry, sex, age, BMI make additive tissue-specific variability, whereas interactions are rare. Variation in dominated by ancestry under genetic control most...