A5018818786- Luminescence and Fluorescent Materials
- Chemical Synthesis and Analysis
- Synthesis and Characterization of Heterocyclic Compounds
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Synthesis and Reactions of Organic Compounds
- Cyclopropane Reaction Mechanisms
- Click Chemistry and Applications
- Synthesis of heterocyclic compounds
- Supramolecular Chemistry and Complexes
- Blood Coagulation and Thrombosis Mechanisms
Anyang Normal University
2024
Eli Lilly (United States)
1997-2000
The crystal structures of four active site-directed thrombin inhibitors, 1-4, in a complex with human alpha-thrombin have been determined and refined at up to 2.0 A resolution using X-ray crystallography. These compounds belong structurally novel family inhibitors based on 2,3-disubstituted benzo[b]thiophene structure. Compared traditional active-site directed the these complexes reveal binding mode. Unexpectedly, lipophilic nucleus inhibitor appears bind S1 specificity pocket. At same time,...
Selective C–C bond cleavage and transformation of organic small molecules to create products increased value are one the central goals in chemistry. In this study, we have developed a novel TEMPO-mediated ring-opening α,β-difunctionalization cyclopropyl alcohols with azides prepare structurally important 4-keto-1,2,3-triazoles under metal- additive-free conditions. This protocol not only provides straightforward efficient method for synthesis 4-keto-functionalized 1,2,3-triazoles pot but...
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