A5049059715- Xenotransplantation and immune response
- Genetic Associations and Epidemiology
- Animal Genetics and Reproduction
- Viral Infectious Diseases and Gene Expression in Insects
- Viral Infections and Vectors
- Tryptophan and brain disorders
- Vector-Borne Animal Diseases
- Asthma and respiratory diseases
- Plant Virus Research Studies
Anhui Medical University
2025
Sichuan Agricultural University
2023
Third People's Hospital of Huzhou
2005
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease caused by the SFTS virus (SFTSV), which has high mortality rates and poses a significant threat to public health. To identify potential therapeutic targets against SFTSV, we conduct genome-wide knockout screening, identifies previously known host factor CCR2, reveals prolow-density lipoprotein receptor-related protein 1 (LRP1) as entry for SFTSV. Knockdown or of LRP1 significantly attenuate SFTSV infection...
Abstract Objectives The final step in the production of human Sd(a) antigen is catalyzed by beta-1,4-N-acetyl-galactosamine transferase 2 ( B4GALNT2 ). This done adding a N-acetylgalactosamine residue via beta-1,4 linkage to subterminal galactose that has been substituted with an alpha-2,3-linked sialic acid. stage Cad also . Knocking out pig gene decreased serum antibodies binding cells, which greatly reduces immunological rejection clinical xenotransplantation trials. Interestingly, region...