A5001671410- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Microbial Natural Products and Biosynthesis
- Metabolism, Diabetes, and Cancer
- Antimicrobial Peptides and Activities
- Phytochemical compounds biological activities
- Ubiquitin and proteasome pathways
- ATP Synthase and ATPases Research
- Metabolomics and Mass Spectrometry Studies
- Genomics and Phylogenetic Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Plant tissue culture and regeneration
- Plant biochemistry and biosynthesis
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
Rockefeller University
2023-2024
Tri-Institutional PhD Program in Chemical Biology
2024
Weill Cornell Medicine
2018-2022
Cornell University
2018-2022
Most biosynthetic gene clusters (BGCs) are functionally inaccessible by using fermentation methods. Bioinformatic-coupled total synthesis provides an alternative approach for accessing BGC-encoded bioactivities. To date, synthetic bioinformatic natural product (synBNP) methods have focused on lipopeptides containing simple lipids. Here we increase the and complexity of synBNP targeting BGCs that encode N-cinnamoyl This led to our cinnamosyn, a 10-mer N-cinnamoyl-containing peptide is...
Cilagicin is a dual polyprenyl phosphate binding lipodepsipeptide antibiotic with strong activity against clinically relevant Gram-positive pathogens while evading resistance. showed high serum that reduced its in vivo efficacy. Cilagicin-BP, which contains biphenyl moiety place of the N-terminal myristic acid found on cilagicin, and increased efficacy but decreased potency some pathogens. Here, we manipulated acyl tail peptide core cilagicin to identify an optimized collection structural...
Cilagicin is a Gram-positive active antibiotic that has dual polyprenyl phosphate binding mechanism impedes resistance development. Here we bioinformatically screened predicted non-ribosomal polypeptide synthetase encoded structures to search for antibiotics might similarly avoid Synthesis and bioactivity screening of the identified led three are against multidrug-resistant pathogens, two which, paenilagicin virgilagicin, did not lead even after prolonged exposure.
Summary From age 65 onwards, the risk of cancer incidence and associated mortality is substantially higher 1-3 . Nonetheless, our understanding complex relationship between still in its infancy 4 For decades, link has largely been attributed to increased exposure time mutagens older individuals. However, this view does not account for well-established role diet, exercise small molecules that target pace metabolic aging 5-8 Here, we show alterations occur with can render a systemic...