A5090233493- Cardiac Fibrosis and Remodeling
- Cardiac Valve Diseases and Treatments
- Cellular Mechanics and Interactions
- Rheology and Fluid Dynamics Studies
- RNA Research and Splicing
- Congenital heart defects research
- Cancer-related molecular mechanisms research
- Force Microscopy Techniques and Applications
- Single-cell and spatial transcriptomics
Australian Regenerative Medicine Institute
2023-2025
Monash University
2023-2025
The University of Texas at Austin
2002
Abstract Aims The highly conserved long non-coding RNA (lncRNA) MIR505HG has been primarily recognized as a precursor for microRNAs (miR)-424 and miR-503. However, studies have since demonstrated that MIR503HG distinct functions from its associated miRNAs, playing important roles in cell proliferation, invasion, apoptosis, differentiation. While these miRNAs are known to influence cardiomyocyte differentiation, the specific role of heart development remains unexplored. We seek determine how...
The cardiac endothelium influences ventricular chamber development by coordinating trabeculation and compaction. However, the endothelial-specific molecular mechanisms mediating this coordination are not fully understood. Here, we identify Sox7 transcription factor as a critical cue instructing identity during development. Endothelial-specific loss of function in mice results defects similar to non-compaction cardiomyopathy, with change proportions trabecular compact cardiomyocytes mutant...