A5042316385- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Molecular Biology Techniques and Applications
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
Chongqing Cancer Hospital
2024
Chongqing University
2024
Purpose: To evaluate the predictive capacity of nutritional-inflammatory index and clinicopathological characteristics in patients with locally advanced rectal cancer (LARC) receiving total neoadjuvant therapy (TNT). Methods: Data from 127 LARC TNT January 2017 to 2021 were retrospectively analyzed. Clinicopathological different TNT-induced responses compared. The Chi-square test Mann–Whitney used analyze association between pre-TNT factors responses. Multivariable logistic regression...
<div>Abstract<p>Circular RNA (circRNA) is a class of noncoding whose functions remain mostly unknown. Recent studies indicate circRNA may be involved in disease pathogenesis, but direct evidence scarce. Here, we characterize the functional role novel circRNA, circCCDC66, colorectal cancer. RNA-Seq data from matched normal and tumor colon tissue samples identified numerous circRNAs specifically elevated cancer cells, several which were verified by quantitative RT-PCR. CircCCDC66...
<p>Table S1. Sequences of siRNA oligonucleotides used in this study. Table S2. primers for quantitative PCR. S3. cloning.</p>
<p>The list of miRNAs targeting exons 8 to 10 CCDC66</p>
<p>Figure S1. Alignments between full-length read to exon(s). Figure S2. CircRNAs validation in CRC. S3. Sanger sequencing results for the backsplice junction. S4. Hypoxia tunes levels of linear and circular CCDC66 transcripts. S5. CircCCDC66 reshapes tumor transcriptome. S6. regulates a subset oncogenes. S7. Levels circCCDC66 from xenografted tumors.</p>
<p>Supplementary Materials and Methods</p>
<p>The list of circRNAs identified in colorectal cancer</p>
<p>Figure S1. Alignments between full-length read to exon(s). Figure S2. CircRNAs validation in CRC. S3. Sanger sequencing results for the backsplice junction. S4. Hypoxia tunes levels of linear and circular CCDC66 transcripts. S5. CircCCDC66 reshapes tumor transcriptome. S6. regulates a subset oncogenes. S7. Levels circCCDC66 from xenografted tumors.</p>
<p>Supplementary Materials and Methods</p>
<p>The list of miRNAs targeting exons 8 to 10 CCDC66</p>
<p>The list of circRNAs identified in colorectal cancer</p>
<p>Table S1. Sequences of siRNA oligonucleotides used in this study. Table S2. primers for quantitative PCR. S3. cloning.</p>
<div>Abstract<p>Circular RNA (circRNA) is a class of noncoding whose functions remain mostly unknown. Recent studies indicate circRNA may be involved in disease pathogenesis, but direct evidence scarce. Here, we characterize the functional role novel circRNA, circCCDC66, colorectal cancer. RNA-Seq data from matched normal and tumor colon tissue samples identified numerous circRNAs specifically elevated cancer cells, several which were verified by quantitative RT-PCR. CircCCDC66...