A5092549128- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Antimicrobial Peptides and Activities
- Genetics and Neurodevelopmental Disorders
California Institute of Technology
2025
University of Cambridge
2023-2024
MRC Toxicology Unit
2023-2024
UK Dementia Research Institute
2023
MRC Mitochondrial Biology Unit
2023
Babraham Institute
2023
Nanoparticle vaccines displaying combinations of SARS-like betacoronavirus (sarbecovirus) receptor-binding domains (RBDs) could protect against SARS-CoV-2 variants and spillover zoonotic sarbecoviruses into humans. Using a computational approach, we designed RBDs selected 7 natural sarbecovirus RBDs, each predicted to fold properly abrogate antibody responses variable epitopes. were attached 60-mer nanoparticles make immunogens two (mosaic-2COMs), five (mosaic-5COM), or seven (mosaic-7COM)...
Abstract Organelles form membrane contact sites between each other, allowing for the transfer of molecules and signals. Mitochondria-endoplasmic reticulum (ER) (MERCS) are cellular subdomains characterized by close apposition mitochondria ER membranes. They have been implicated in many diseases, including neurodegenerative, metabolic, cardiac diseases. Although MERCS extensively studied, much remains to be explored. To uncover novel regulators MERCS, we conducted a genome-wide, flow...
Abstract Organelles form membrane contact sites between each other, allowing for the transfer of molecules and signals. Mitochondria-endoplasmic reticulum (ER) (MERCS) are cellular subdomains characterized by close apposition mitochondria ER membranes. They have been implicated in many diseases, including neurodegenerative, metabolic, cardiac diseases. Although MERCS extensively studied, much remains to be explored. To uncover novel regulators MERCS, we conducted a genome-wide, flow...