A5064754104- Venous Thromboembolism Diagnosis and Management
- Single-cell and spatial transcriptomics
- Sarcoma Diagnosis and Treatment
- CAR-T cell therapy research
- Coronary Interventions and Diagnostics
- Advanced Clustering Algorithms Research
- Vascular Procedures and Complications
- Data Management and Algorithms
- Data Analysis with R
- Complex Network Analysis Techniques
California Institute of Technology
2025
ETH Zurich
2022-2023
Wake Research
1998-2000
Rhabdomyosarcoma (RMS) is a group of pediatric cancers with features developing skeletal muscle. The cellular hierarchy and mechanisms leading to developmental arrest remain elusive. Here, we combined single-cell RNA sequencing, mass cytometry, high-content imaging resolve intratumoral heterogeneity patient-derived primary RMS cultures. We show that the aggressive alveolar (aRMS) subtype contains plastic muscle stem-like cells cycling progenitors drive tumor growth, subpopulation...
The purpose of this study was to determine if closure the femoral artery access site using a percutaneous arterial suture device (Perclose, Menlo Park, CA) in patients undergoing coronary stenting can result same benefits as seen with radial access. A total 218 consecutive underwent (109 femoral, 109 radial) by investigators experienced each technique. two groups were matched terms sex, age, clinical presentation (50% acute), number vessels and lesions stented, lesion morphology. relative...
We present repliclust (from repli-cate and clust-er), a Python package for generating synthetic data sets with clusters. Our approach is based on set archetypes, high-level geometric descriptions from which the user can create many different sets, each possessing desired characteristics. The architecture of our software modular object-oriented, decomposing generation into algorithms placing cluster centers, sampling shapes, selecting number points cluster, assigning probability distributions...
ABSTRACT Rhabdomyosarcoma (RMS) is an aggressive human pediatric cancer. Despite robust expression of myogenic regulatory factors, RMS cells are blocked in a proliferative state and do not terminally differentiate. The extent to which the skeletal muscle lineage represented tumors mechanisms leading developmental arrest remain elusive. Here, we combined single-cell RNA sequencing (scRNAseq), mass cytometry (CyTOF) high-content imaging resolve heterogeneity. ScRNAseq CyTOF analysis total 17...