A5063163595- Recommender Systems and Techniques
- Inflammatory mediators and NSAID effects
- Estrogen and related hormone effects
- Eicosanoids and Hypertension Pharmacology
- Asthma and respiratory diseases
- Advanced Graph Neural Networks
- Caching and Content Delivery
- Advanced Bandit Algorithms Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Topic Modeling
- Atherosclerosis and Cardiovascular Diseases
- Digital Media Forensic Detection
- Child Development and Digital Technology
- Pharmacological Effects and Assays
- Immunodeficiency and Autoimmune Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Pharmacogenetics and Drug Metabolism
- Infant Nutrition and Health
- Nitric Oxide and Endothelin Effects
- Eosinophilic Esophagitis
- Medical and Biological Ozone Research
- Internet Traffic Analysis and Secure E-voting
- Radiomics and Machine Learning in Medical Imaging
Kuaishou (China)
2021-2024
Icahn School of Medicine at Mount Sinai
2013-2016
The Mount
2013
Translational Therapeutics (United States)
2006-2012
University of Pennsylvania
2001-2010
The Wistar Institute
2010
Queen's University
2004
Merck & Co., Inc., Rahway, NJ, USA (United States)
2004
Sequential recommendation aims to leverage users' historical behaviors predict their next interaction. Existing works have not yet addressed two main challenges in sequential recommendation. First, user rich sequences are often implicit and noisy preference signals, they cannot sufficiently reflect actual preferences. In addition, dynamic preferences change rapidly over time, hence it is difficult capture patterns sequences. this work, we propose a graph neural network model called SURGE...
Prostaglandin (PG) E(2) is formed from PGH(2) by a series of PGE synthase (PGES) enzymes. Microsomal PGES-1(-/-) (mPGES-1(-/-)) mice were crossed into low-density lipoprotein receptor knockout (LDLR(-/-)) to generate mPGES-1(-/-) LDLR(-/-)s. Urinary 11alpha-hydroxy-9, 15-dioxo-2,3,4,5-tetranor-prostane-1,20-dioic acid (PGE-M) was depressed mPGES-1 deletion. Vascular augmented during atherogenesis in Deletion reduced plaque burden fat-fed LDLR(-/-)s but did not alter blood pressure. LDLR(-/-)...
With the increase of content pages and interactive buttons in online services such as online-shopping video-watching websites, industrial-scale recommender systems face challenges multi-domain multi-task recommendations. The core recommendation is to accurately capture user interests multiple scenarios given behaviors. In this paper, we propose a plug-and-play Parameter Embedding Personalized Network (PEPNet) for recommendation. PEPNet takes personalized prior information input dynamically...
Nonsteroidal anti-inflammatory drugs selective for inhibition of COX-2 increase heart failure and elevate blood pressure. The gene was floxed crossed into merCremer mice under the alpha-myosin heavy-chain promoter. Tamoxifen induced deletion in cardiomyocytes depressed cardiac output, resulted weight loss, diminished exercise tolerance, enhanced susceptibility to arrhythmogenesis. dysfunction subsequent pressure overload recovered progressively knockouts coincident with increasing...
Background— The proinflammatory and vascular actions of cysteinyl leukotrienes (CysLTs) are mediated by 2 receptors: leukotriene 1 receptor (CysLT R) R). However, the distinct contribution CysLT R to CysLTs has not been addressed. Methods Results— We generated an endothelial cell–specific human (EC-hCysLT transgenic (TG) mouse model using Tie2 promoter/enhancer. Strong expression hCysLT in TG lung cells, detected real-time polymerase chain reaction, markedly enhanced CysLT-stimulated...
Although the dominant product of vascular Cyclooxygenase-2 (COX-2), prostacyclin (PGI(2)), restrains atherogenesis, inhibition and deletion COX-2 have yielded conflicting results in mouse models atherosclerosis. Floxed mice were used to parse distinct cellular contributions macrophages T cells (TCs) atherogenesis.Deletion macrophage-COX-2 (Mac-COX-2KOs) was attained with LysMCre completely suppressed lipopolysaccharide-stimulated macrophage prostaglandin (PG) formation...
Suppression of cyclooxygenase 2 (COX-2)–derived prostacyclin (PGI ) is sufficient to explain most elements the cardiovascular hazard from nonsteroidal antinflammatory drugs (NSAIDs). However, randomized trials are consistent with emergence risk during chronic dosing NSAIDs. Although deletion PGI receptor fosters atherogenesis, importance COX-2 development has constrained use conventional knockout (KO) mice address this question. We developed in which was deleted postnatally, bypassing...
Two classes of cysteinyl leukotriene receptor, CysLT(1) and CysLT(2), have been identified pharmacologically characterized in human tissues. Although the receptor mediates proinflammatory effects leukotrienes asthma, physiological roles CysLT(2) are not defined, a suitable mouse model would be useful delineating function. We report here molecular cloning characterization (mCysLT(2)R) from heart tissue. mCysLT(2)R cDNA encodes protein 309 amino acids, truncated at both ends compared with...
The prostaglandin G/H synthase enzymes, commonly termed COX-1 and COX-2, differ markedly in their responses to regulatory stimuli tissue expression patterns. is the dominant source of "housekeeping" prostaglandins, whereas COX-2 synthesizes prostaglandins relevance pain, inflammation, mitogenesis. Despite these distinctions, two enzymes are remarkably conserved, subcellular distributions overlap considerably. To address functional interchangeability isozymes, mice which expressed under...
Life-long user behavior modeling, i.e., extracting a user's hidden interests from rich historical behaviors in months or even years, plays central role modern CTR prediction systems. Conventional algorithms mostly follow two cascading stages: simple General Search Unit (GSU) for fast and coarse search over tens of thousands long-term an Exact (ESU) effective Target Attention (TA) the small number finalists GSU. Although efficient, existing suffer crucial limitation: inconsistent...
Nonsteroidal anti-inflammatory drugs ameliorate pain and fever by inhibiting cyclooxygenase (COX) suppressing prostanoid formation. Microsomal prostaglandin E synthase-1 (mPGES-1) catalyzes formation of PGE<sub>2</sub> from the COX product PGH<sub>2</sub> has emerged as a therapeutic target. Inhibition mPGES-1, however, renders substrate available for diversion to other PG synthases. To address possibility that augments PGs might modulate bronchial tone, we assessed impact mPGES-1 deletion...
The significance of modeling long-term user interests for CTR prediction tasks in large-scale recommendation systems is progressively gaining attention among researchers and practitioners. Existing work, such as SIM TWIN, typically employs a two-stage approach to model behavior sequences efficiency concerns. first stage rapidly retrieves subset related the target item from long sequence using search-based mechanism namely General Search Unit (GSU), while second calculates interest scores...
Industrial recommendation systems (RS) rely on the multi-stage pipeline to balance effectiveness and efficiency when delivering items from a vast corpus users. Existing RS benchmark datasets primarily focus exposure space, where novel algorithms are trained evaluated. However, these transition real world industrial RS, they face critical challenge of handling unexposed which significantly larger space than exposed one. This discrepancy profoundly impacts their practical performance....
Sequential recommendation aims to leverage users' historical behaviors predict their next interaction. Existing works have not yet addressed two main challenges in sequential recommendation. First, user rich sequences are often implicit and noisy preference signals, they cannot sufficiently reflect actual preferences. In addition, dynamic preferences change rapidly over time, hence it is difficult capture patterns sequences. this work, we propose a graph neural network model called SURGE...
Life-long user behavior modeling, i.e., extracting a user's hidden interests from rich historical behaviors in months or even years, plays central role modern CTR prediction systems. Conventional algorithms mostly follow two cascading stages: simple General Search Unit (GSU) for fast and coarse search over tens of thousands long-term an Exact (ESU) effective Target Attention (TA) the small number finalists GSU. Although efficient, existing suffer crucial limitation: \textit{inconsistent}...
With the increase of content pages and interactive buttons in online services such as online-shopping video-watching websites, industrial-scale recommender systems face challenges multi-domain multi-task recommendations. The core recommendation is to accurately capture user interests multiple scenarios given behaviors. In this paper, we propose a plug-and-play \textit{\textbf{P}arameter \textbf{E}mbedding \textbf{P}ersonalized \textbf{Net}work (\textbf{PEPNet})} for recommendation. PEPNet...
Nonsteroidal anti-inflammatory drugs, including those selective for cyclooxygenase (COX) - 2 relieve pain and inflammation. Thus, suppression of COX-2 derived proinflammatory products is a cardinal feature NSAID efficacy. The use conventional knockout mice to explore this biology constrained by the multiple roles in development early postnatal life. To circumvent these limitations we generated with tissue-specific deletion macrophages (COX-2 Mac−/− ) confirmed absence LPS inducible mRNA...