A5069332797- Peptidase Inhibition and Analysis
- Plant and animal studies
- Cancer therapeutics and mechanisms
- Cocoa and Sweet Potato Agronomy
- Traditional and Medicinal Uses of Annonaceae
- Multiple Myeloma Research and Treatments
- Plant Diversity and Evolution
- Plant and Fungal Species Descriptions
- Protein Degradation and Inhibitors
- Plant Parasitism and Resistance
- Click Chemistry and Applications
- Synthesis and biological activity
Nanjing University of Chinese Medicine
2015-2024
Four new annonaceous acetogenins (ACGs), squamocin-I (1), II (2) and III (3) squamoxinone-D (4), together with seven known ACGs (5–11), were isolated from the seeds of Annona squamosa. The structures all isolates elucidated characterised by spectral chemical methods. Compounds 1–4 evaluated for their cytotoxicities against Hep G2, SMMC 7721, BEL 7402, BGC 803 H460 human cancer cell lines. Compound 1 exhibited better potent activity than positive compound 3 shows selectively cytotoxical IC50...
Bioorthogonal cleavage reactions have been developed as an intriguing strategy to enhance the safety of chemotherapeutics. Aiming reduce toxicity and improve targeted release properties colchicine binding site inhibitors (CBSIs) based on previous work, a series biologically inert prodrugs were further designed synthesized through bioorthogonal prodrug strategy. The therapeutic effects could be "turned-on" once combined with palladium resins. Particularly, 2b was 68.3-fold less cytotoxic...