A5113159679- Reproductive Biology and Fertility
- Ovarian function and disorders
- Computational Drug Discovery Methods
- Genetics, Bioinformatics, and Biomedical Research
- Peptidase Inhibition and Analysis
- Chromatin Remodeling and Cancer
- Bioinformatics and Genomic Networks
- Extracellular vesicles in disease
- Microtubule and mitosis dynamics
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Machine Learning in Materials Science
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Cellular Mechanics and Interactions
- Protein Structure and Dynamics
- MicroRNA in disease regulation
- Sperm and Testicular Function
- 14-3-3 protein interactions
- Theoretical and Computational Physics
Institut de Biologie Intégrative de la Cellule
2023-2025
Université Paris-Saclay
2023-2025
Centre National de la Recherche Scientifique
2023-2025
CEA Paris-Saclay
2023-2025
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2023-2025
Ningxia Medical University
2024
Ningxia Medical University General Hospital
2024
The revolution brought about by AlphaFold2 opens promising perspectives to unravel the complexity of protein-protein interaction networks. analysis networks obtained from proteomics experiments does not systematically provide delimitations regions. This is particular concern in case interactions mediated intrinsically disordered regions, which site generally small. Using a dataset protein-peptide complexes involving regions that are non-redundant with structures used training, we show when...
Abstract Genomic instability can trigger cancer-intrinsic innate immune responses that promote tumor rejection. However, cancer cells often evade these by overexpressing checkpoint regulators, such as PD-L1. Here, we identify the SNF2-family DNA translocase SMARCAL1 a factor favors evasion dual mechanism involving both suppression of signaling and induction PD-L1-mediated responses. Mechanistically, relieves endogenous damage suppresses cGAS-STING-dependent during cell growth....
<title>Abstract</title> Diminished ovarian reserve (DOR) is a multi-factor gynecological disease that has become major global health problem. Currently, there no effective prevention and therapy for DOR. Exosome-drived long non-coding RNAs (lncRNA) in follicular fluid (FF) plays vital role development of follicles. lncRNA LIPE-AS1, which we screened from FF patients with DOR, regulates histone deacetylase 3 (HDAC3) expression by competitively inhibiting miR-330-5p. Exosomes as nanosized...